DM1-AS

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Annotated Information

Name

DM1-AS:DM1 locus antisense RNA

Characteristics

DM1-AS spans >6 kb, contains alternative transcription start sites and uses alternative polyadenylation sites up- and downstream of the (CAG)n repeat. [1]

Cellular Localization

DM1-AS transcripts are present in the nucleus and in the cytoplasm.[1]

Expression

The DM1-AS transcript is a low-abundance RNA[1].

DM1-AS expression appears upregulated in patients, but transcript abundance remains very low in some tissues. In addition, DM1-AS expression was lowest in brain and highest in kidney, testis and muscle.[1]

Diseases

Myotonic dystrophy type 1[1]

Labs working on this lncRNA

  • a Radboud University Medical Center , Department of Cell Biology , Nijmegen , The Netherlands.

References

  1. 1.0 1.1 1.2 1.3 1.4 Gudde AEEG, van Heeringen SJ, de Oude AI, van Kessel IDG, Estabrook J, Wang ET, Wieringa B, Wansink DG. Antisense transcription of the myotonic dystrophy locus yields low-abundant RNAs with and without (CAG)n repeat. RNA Biol. 2017 Jan 19:1-15.