Difference between revisions of "DSCAM-AS1"
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==Annotated Information== | ==Annotated Information== | ||
===Approved Symbol=== | ===Approved Symbol=== | ||
| − | DSCAM-AS1 | + | DSCAM-AS1 （DSCAM antisense RNA 1） |
| − | = | + | [[File:Characterization of DSCAM-AS1.jpg|right|thumb|400px|'''Characterization of DSCAM-AS1'''<ref name="ref1" />]] |
| − | DSCAM | + | [[File:Physical and functional relationship of DSCAM-AS1 with hnRNPL.jpg|right|thumb|400px|'''Physical and functional relationship of DSCAM-AS1 with hnRNPL'''<ref name="ref1" />]] |
| − | + | ||
| − | |||
===Synonyms=== | ===Synonyms=== | ||
M41 | M41 | ||
===Chromosome=== | ===Chromosome=== | ||
21q22.2 | 21q22.2 | ||
| − | |||
| − | |||
| − | |||
| − | |||
===RefSeq(supplied by NCBI)=== | ===RefSeq(supplied by NCBI)=== | ||
NR_038896 | NR_038896 | ||
| − | === | + | ===Disease=== |
| − | + | breast cancer | |
| + | ===Characteristics=== | ||
| + | ER preferentially binds to the DSCAM-AS1 promoter in tumours with clinical aggression.<ref name="ref1" /> | ||
| + | |||
| + | ===Function=== | ||
| + | DSCAM-AS1 mediates tumour progression and tamoxifen resistance.<ref name="ref1" /> | ||
| + | DSCAM-AS1 provides oestrogen-independent growth and a proliferative advantage when grown in oestrogen-deprived medium compared to normal serum.<ref name="ref1" /> | ||
| + | |||
| + | ===Regulation=== | ||
| + | hnRNPL is an interacting protein involved in the mechanism of DSCAM-AS1 action.<ref name="ref1" /> | ||
| + | |||
| + | ===Expression=== | ||
| + | DSCAM-AS1 expression is highly enriched in ER-positive tumours.<ref name="ref1" /> | ||
| + | |||
| + | ==Labs working on this lncRNA== | ||
| + | * Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA | ||
| + | * Department of Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan 48109, USA. | ||
| + | |||
| + | ==References== | ||
| + | <references> | ||
| + | <ref name="ref1"> Niknafs, Y.S., et al., The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression. Nat Commun, 2016. 7: p. 12791. | ||
| + | </ref>(1) | ||
| + | </references> | ||
Latest revision as of 08:33, 13 November 2017
Contents
Annotated Information
Approved Symbol
DSCAM-AS1 （DSCAM antisense RNA 1）
Characterization of DSCAM-AS1[1]
Physical and functional relationship of DSCAM-AS1 with hnRNPL[1]
Synonyms
M41
Chromosome
21q22.2
RefSeq(supplied by NCBI)
NR_038896
Disease
breast cancer
Characteristics
ER preferentially binds to the DSCAM-AS1 promoter in tumours with clinical aggression.[1]
Function
DSCAM-AS1 mediates tumour progression and tamoxifen resistance.[1] DSCAM-AS1 provides oestrogen-independent growth and a proliferative advantage when grown in oestrogen-deprived medium compared to normal serum.[1]
Regulation
hnRNPL is an interacting protein involved in the mechanism of DSCAM-AS1 action.[1]
Expression
DSCAM-AS1 expression is highly enriched in ER-positive tumours.[1]
Labs working on this lncRNA
- Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
- Department of Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan 48109, USA.
