Difference between revisions of "ENST00000412690.1"

From LncRNAWiki
Jump to: navigation, search
Line 1: Line 1:
−
Please input one-sentence summary here.
+
''LINC01191'', a 869bp long non-coding RNA, which is induced by several IAV(influenza A virus) strains (H1N1, H3N2, H7N7) as well as vesicular stomatitis virus, functions in IAV propagation.
  
 
==Annotated Information==
 
==Annotated Information==
 
===Transcriptomic Nomeclature===
 
===Transcriptomic Nomeclature===
−
Please input transcriptomic nomeclature information here.
+
LINC01191: long intergenic non-protein coding RNA 1191(HGNC nomenclature)
 +
 
 +
''lnc-ACTR3'', ''VIN'', "virus inducible lincRNa"<ref name="ref1" />
 +
 
 +
===Characteristics==
 +
[[File:In silico characterization of VIN. jpg|right|thumb|400px|'''In silico characterization of VIN'''<ref name="ref1" />]]
 +
 
 +
''LINC01191'',virus inducible lincRNA (VIN), is induced by several IAV(influenza A virus) strains (H1N1, H3N2, H7N7) as well as vesicular stomatitis virus<ref name="ref1" />.
 +
 
 +
===Cellular Localization===
 +
VIN is localized to the host cell nucleus<ref name="ref1" />.
  
 
===Function===
 
===Function===
−
Please input function information here.
+
VIN expression was specifically induced upon infection with a number of IAV and VSV(vesicular stomatitis virus), suggesting that this lincRNA may have broader functionality during virus infection<ref name="ref1" />.  
  
−
===Regulation===
+
VIN adopts stable secondary structures, and thus, has a functional role in cells, perhaps in complex with other cellular components as it was largely insensitive to endonuclease<ref name="ref1" />.
−
Please input regulation information here.
+
 
 +
Nuclear expression of VIN suggests an involvement in gene-regulatory processes and VIN is functionally relevant during pathogenesis of IAV infection which strengthens the view that lncRNAs are major players in diverse biological processes<ref name="ref1" />.
 +
 
 +
===Disease===
 +
* influenza
  
 
===Expression===
 
===Expression===
−
Please input expression information here.
+
VIN expression seems to be a specific response to certain viral infections including IAV and VSV<ref name="ref1" />.
−
 
 
−
===Allelic Information and Variation===
 
−
Please input allelic information and variation information here.
 
  
−
===Evolution===
+
{|class=’wikitable’ style=”text-align:center”
−
Please input evolution information here.
+
|-
 +
! |siRNA
 +
! |sequence 5’-3’
 +
|-
 +
| rowspan=”1”|IAV Nucleoprotein
 +
| | AAGGAUCUUAUUUCUUCGGAG<ref name=”ref1” />
 +
|-
 +
| rowspan=”1”|VIN siRNA 1
 +
| | CTGTGACATGTAGATTGCTAA<ref name=”ref1” />
 +
|-
 +
| rowspan=”1”|VIN siRNA 2
 +
| | CCGGAGCCGTTTACAGTTTGA<ref name=”ref1” />
 +
|-
 +
| rowspan=”1”|VIN siRNA 3
 +
| | CGCGCCCTGTCCCGCCATATA<ref name=”ref1” />
 +
|}
  
−
You can also add sub-section(s) at will.
 
  
 
==Labs working on this lncRNA==
 
==Labs working on this lncRNA==
−
Please input related labs here.
+
* Department of Molecular Biology; Max Planck Institute for Infection Biology; Berlin, Germany<ref name="ref1" />
  
 
==References==
 
==References==
−
Please input cited references here.
+
<references>
 +
<ref name="ref1">Winterling C, Koch M, Koeppel M, Garcia-Alcalde F, Karlas A, Meyer TF. Evidence for a crucial role of a host non-coding RNA in influenza A virus replication[J]. RNA biology. 2014,11(1):66-75.</ref>(1)
 +
</references>
  
 
{{basic|
 
{{basic|
 
tID = ENST00000412690.1|
 
tID = ENST00000412690.1|
 
source = Gencode19|
 
source = Gencode19|
−
same = lnc-ACTR3-1:1|
+
same = lnc-ACTR3-1:1,''LINC01191'',''lnc-ACTR3'', ''VIN''|
 
classification = intergenic|
 
classification = intergenic|
 
length = 844 nt|
 
length = 844 nt|

Revision as of 06:24, 11 April 2015

LINC01191, a 869bp long non-coding RNA, which is induced by several IAV(influenza A virus) strains (H1N1, H3N2, H7N7) as well as vesicular stomatitis virus, functions in IAV propagation.

Annotated Information

Transcriptomic Nomeclature

LINC01191: long intergenic non-protein coding RNA 1191(HGNC nomenclature)

lnc-ACTR3, VIN, "virus inducible lincRNa"[1]

=Characteristics

File:In silico characterization of VIN. jpg
In silico characterization of VIN[1]

LINC01191,virus inducible lincRNA (VIN), is induced by several IAV(influenza A virus) strains (H1N1, H3N2, H7N7) as well as vesicular stomatitis virus[1].

Cellular Localization

VIN is localized to the host cell nucleus[1].

Function

VIN expression was specifically induced upon infection with a number of IAV and VSV(vesicular stomatitis virus), suggesting that this lincRNA may have broader functionality during virus infection[1].

VIN adopts stable secondary structures, and thus, has a functional role in cells, perhaps in complex with other cellular components as it was largely insensitive to endonuclease[1].

Nuclear expression of VIN suggests an involvement in gene-regulatory processes and VIN is functionally relevant during pathogenesis of IAV infection which strengthens the view that lncRNAs are major players in diverse biological processes[1].

Disease

  • influenza

Expression

VIN expression seems to be a specific response to certain viral infections including IAV and VSV[1].

siRNA sequence 5’-3’
IAV Nucleoprotein AAGGAUCUUAUUUCUUCGGAG[2]
VIN siRNA 1 CTGTGACATGTAGATTGCTAA[2]
VIN siRNA 2 CCGGAGCCGTTTACAGTTTGA[2]
VIN siRNA 3 CGCGCCCTGTCCCGCCATATA[2]


Labs working on this lncRNA

  • Department of Molecular Biology; Max Planck Institute for Infection Biology; Berlin, Germany[1]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Winterling C, Koch M, Koeppel M, Garcia-Alcalde F, Karlas A, Meyer TF. Evidence for a crucial role of a host non-coding RNA in influenza A virus replication[J]. RNA biology. 2014,11(1):66-75.
  2. ↑ 2.0 2.1 2.2 2.3 Cite error: Invalid <ref> tag; no text was provided for refs named .E2.80.9Dref1.E2.80.9D

Basic Information

Transcript ID

ENST00000412690.1

Source

Gencode19

Same with

lnc-ACTR3-1:1,LINC01191,lnc-ACTR3, VIN

Classification

intergenic

Length

844 nt

Genomic location

chr2+:114737146..114764879

Exon number

2

Exons

114737146..114737705,114764596..114764879

Genome context

Sequence
000001 CCGGATTCCG AAGCCCGGAG CCGTTTACAG TTTGAGGCGC CGTGTGCCGC CCCCTGGTGG CCGGAGGCCG TTACTGTCGC 000080
000081 GGCTGAGGGG GCGTCCCGGT GTATCCGCAG CGCGCCCTGG CCGCCCTCTG GTGGCCGGAG GCCGTTACTG TCGCGGCTGA 000160
000161 GGGGGCGTCC CGGTGTATCC GCAGCGCGCC CTGGCCGCCC CCTGGTGGCC GGAGGCCGTT ACTGTCGCGG CTGAGGGGGC 000240
000241 GTCCCGGTGT ATCCGCAGCG CGCCCTGGCC GACCCCTGGT GGCCGGAGGC CGTTACTGTC GCGGCTGAAG GGGCGTGTCC 000320
000321 CGGTGTATCC GCAGCGCGCC CTGGCTGCCC CCTGGTGGCC GGAGGCCGTT ACTGTCGCGG CTGAGGGGGC GTCCCGGTGT 000400
000401 ATCCGCAGCG CGCCCTGTCC CGCCATATAC ATTCCGTGCT TTTCAAACAC CCGCCGTGGG CTAAGCATGG GACCCACGTG 000480
000481 GGGCGGGGAC ACACGGCGAT AAAGAGCCAG GCCCTCGCTG CCAAGGAGCT TTCCCGTAAC ACCGATGCAT CAAACAAAAG 000560
000561 GCAGCAGTGA GGATGCCAGA GTTCATGGGT TTCTAGAAGA CAAGTTTTCA ACTGCAGATA CAAACATCAG GACGTCAATG 000640
000641 TATCTGCTAG GAGACACCCG GACAGTGTTG AGAACACAGA ACCTGGAGGC TAAACCCCCA GCTTTCTATG CCAGCTGAGA 000720
000721 GTCTGTGGGC ACATTACTCA GCGTCTCTGA ACCTCATGCT CCTCCCCTGT GACATGTAGA TTGCTAAACC CATCTCACAG 000800
000801 GGCTATCTTC TGCATTTAAA GAATAAAATA ACACATGAGG GGTC
[back to top]
Retrieved from "https://ngdc.cncb.ac.cn/lncrnawiki1/index.php?title=ENST00000412690.1&oldid=1270741"