Difference between revisions of "FENDRR"
| Line 17: | Line 17: | ||
===Diseases=== | ===Diseases=== | ||
| − | * gastric cancer | + | * gastric cancer <ref name="ref1" /> |
===Function=== | ===Function=== | ||
| − | FENDRR is essential for proper heart and body wall development in mouse <ref name="ref2" />. It is also involved in lung development. Deletion of FENDRR causes a lethal lung developmental disorder <ref name="ref3" />. | + | FENDRR is essential for proper heart and body wall development in mouse <ref name="ref2" />. It is also involved in lung development. Deletion of FENDRR causes a lethal lung developmental disorder <ref name="ref3" />. FENDRR is dramatically downregulated in gastric cancer tissues and cell lines, and downregulation of FENDRR is significantly associated with invasion depth, tumor stage, lymphatic metastasis and patients'survival time. FENDRR may suppress gastric cancer cell migration and invasion by targeting FN1 and MMP2/MMP9 <ref name="ref1" />. |
===Expression=== | ===Expression=== | ||
Revision as of 02:07, 7 September 2016
FENDRR
Contents
Annotated Information
Name
Decreased expression ofFENDRRin gastric cancer cells; histone deacetylation is involved inFENDRRdownregulation. [1].
FENDRR: FOXF1 adjacent non-coding developmental regulatory RNA .
Previous Name: "FOXF1 antisense RNA 1 (head to head)", FOXF1-AS1
ID
GenBank ID: KC505631.1
HGNC ID:49667
Characteristics
Chromosome location:16q24.1
Diseases
- gastric cancer [1]
Function
FENDRR is essential for proper heart and body wall development in mouse [2]. It is also involved in lung development. Deletion of FENDRR causes a lethal lung developmental disorder [3]. FENDRR is dramatically downregulated in gastric cancer tissues and cell lines, and downregulation of FENDRR is significantly associated with invasion depth, tumor stage, lymphatic metastasis and patients'survival time. FENDRR may suppress gastric cancer cell migration and invasion by targeting FN1 and MMP2/MMP9 [1].
Expression
DNA methylation contribution little to FENDRR expression.[1]
Sequence
>gi|299890835|ref|NR_033925.1| Homo sapiens FOXF1 adjacent non-coding developmental regulatory RNA (FENDRR), transcript variant 1, long non-coding RNA
000001 AGCCCCTAGC GCAGACGGCG GAGAGCAGAG AGGGAGCGCG CCTTGGCTCG CTGGCCTTGG CGGCGGCTCC TCAGGAGAGC 000080
000081 TGGGGCGCCC ACGAGAGGAT CCCTCACCCG GGTCTCTCCT CAGGGATGAC ATCATCCGTC CACCTCCTTG TCTTCAAGGA 000160
000161 CCACCTCCTC TCCATGCTGA GCTGCTGCCA AGGGGCCTGC TGCCCATCTA CACCTCACGA GGGCACTAGG AGCACGGTTT 000240
000241 CCTGGATCCC ACCAACATAC AAAGCAGCCA CTCACTGACC CCCAGGACCA GGATGGCAAA GGATGAAGAG GACCGGAACT 000320
000321 GACCAGCCAG CTGTCCCTCT TACCTAAAGA CTTAAACCAA TGCCCTAGTG AGGGGGCATT GGGCATTAAG CCCTGACCTT 000400
000401 TGCTATGCTC ATACTTTGAC TCTATGAGTA CTTTCCTATA AGTCTTTGCT TGTGTTCACC TGCTAGCAAA CTGGAGTGTT 000480
000481 TCCCTCCCCA AGGGGGTGTC AGTCTTTGTC GACTGACTCT GTCATCACCC TTATGATGTC CTGAATGGAA GGATCCCTTT 000560
000561 GGGAAATTCT CAGGAGGGGG ACCTGGGCCA AGGGCTTGGC CAGCATCCTG CTGGCAACTC CAAGGCCCTG GGTGGGCTTC 000640
000641 TGGAATGAGC ATGCTACTGA ATCACCAAAG GCACGCCCGA CCTCTCTGAA GATCTTCCTA TCCTTTTCTG GGGGAATGGG 000720
000721 GTCGATGAGA GCAACCTCCT AGGGTTGTTG TGAGAATTAA ATGAGATAAA AGAGGCCTCA GGCAGGATCT GGCATAGAGG 000800
000801 AGGTGATCAG CAAATGTTTG TTGAAAAGGT TTGACAGGTC AGTCCCTTCC CACCCCTCTT GCTTGTCTTA CTTGTCTTAT 000880
000881 TTATTCTCCA ACAGCACTCC AGGCAGCCCT TGTCCACGGG CTCTCCTTGC ATCAGGACGA ATAATTTATG GTCAGTGAAA 000960
000961 ATCCAGGCCC CAGTGAGATT CGAGTGGGCT GTAAAATCGA GAGTCCTGCT CCCACAGGTT CCCAGTGCCC CCGACAAGCC 001040
001041 CCTGCTGGTG TCTCCATCTC CTGCCAAGCA TCCTCCAGTG CCTCCTCCTG TGGGCCTGGC CTCAGGGCTA TGGACAGACT 001120
001121 CCTGTCCCAT CCCAGAGACC CCTCGTGATC GTGCCCTGGC ACGTGGGCCG TGGCCCGGCT GGGTCGGCTG AAGAACTGCG 001200
001201 GATGGAAGCT GCGGAAGAGG CCCTGATGGG GCCCACCATC CCGGACCCAA GTCTTCTTCC TGGCGGGCCT CTCGTCTCCT 001280
001281 TCCTGGTTTG GGCGGAAGCC ATCACCTGGA TGCCTACGTG GGAAGGGACC TCGAATGTGG GACCCCAGCC CCTCTCCAGC 001360
001361 TCGAAATCCC TCCACAGCCA CGGGGACACC CTGCACCTAT TCCCACGGGA CAGGCTGGAC CCAGAGACTC TGGACCCGGG 001440
001441 GCCTCCCCTT GAGTAGAGAC CCGCCCTCTG ACTGATGGAC GCCGCTGACC TGGGGTCAGA CCCGTGGGCT GGACCCCTGC 001520
001521 CCACCCCGCA GGAACCCTGA GGCCTAGGGG AGCTGTTGAG CCTTCAGTGT CTGCATGTGG GAAGTGGGCT CCTTCACCTA 001600
001601 CCTCACAGGG CTGTTGTGAG GGGCGCTGTG ATGCGGTTCC AAAGCACAGG GCTTGGCGCA CCCCACTGTG CTCTCAATAA 001680
001681 ATGTGTTTCC TGTCTTAACA AAAAAAAAAA AAAA
000081 TGGGGCGCCC ACGAGAGGAT CCCTCACCCG GGTCTCTCCT CAGGGATGAC ATCATCCGTC CACCTCCTTG TCTTCAAGGA 000160
000161 CCACCTCCTC TCCATGCTGA GCTGCTGCCA AGGGGCCTGC TGCCCATCTA CACCTCACGA GGGCACTAGG AGCACGGTTT 000240
000241 CCTGGATCCC ACCAACATAC AAAGCAGCCA CTCACTGACC CCCAGGACCA GGATGGCAAA GGATGAAGAG GACCGGAACT 000320
000321 GACCAGCCAG CTGTCCCTCT TACCTAAAGA CTTAAACCAA TGCCCTAGTG AGGGGGCATT GGGCATTAAG CCCTGACCTT 000400
000401 TGCTATGCTC ATACTTTGAC TCTATGAGTA CTTTCCTATA AGTCTTTGCT TGTGTTCACC TGCTAGCAAA CTGGAGTGTT 000480
000481 TCCCTCCCCA AGGGGGTGTC AGTCTTTGTC GACTGACTCT GTCATCACCC TTATGATGTC CTGAATGGAA GGATCCCTTT 000560
000561 GGGAAATTCT CAGGAGGGGG ACCTGGGCCA AGGGCTTGGC CAGCATCCTG CTGGCAACTC CAAGGCCCTG GGTGGGCTTC 000640
000641 TGGAATGAGC ATGCTACTGA ATCACCAAAG GCACGCCCGA CCTCTCTGAA GATCTTCCTA TCCTTTTCTG GGGGAATGGG 000720
000721 GTCGATGAGA GCAACCTCCT AGGGTTGTTG TGAGAATTAA ATGAGATAAA AGAGGCCTCA GGCAGGATCT GGCATAGAGG 000800
000801 AGGTGATCAG CAAATGTTTG TTGAAAAGGT TTGACAGGTC AGTCCCTTCC CACCCCTCTT GCTTGTCTTA CTTGTCTTAT 000880
000881 TTATTCTCCA ACAGCACTCC AGGCAGCCCT TGTCCACGGG CTCTCCTTGC ATCAGGACGA ATAATTTATG GTCAGTGAAA 000960
000961 ATCCAGGCCC CAGTGAGATT CGAGTGGGCT GTAAAATCGA GAGTCCTGCT CCCACAGGTT CCCAGTGCCC CCGACAAGCC 001040
001041 CCTGCTGGTG TCTCCATCTC CTGCCAAGCA TCCTCCAGTG CCTCCTCCTG TGGGCCTGGC CTCAGGGCTA TGGACAGACT 001120
001121 CCTGTCCCAT CCCAGAGACC CCTCGTGATC GTGCCCTGGC ACGTGGGCCG TGGCCCGGCT GGGTCGGCTG AAGAACTGCG 001200
001201 GATGGAAGCT GCGGAAGAGG CCCTGATGGG GCCCACCATC CCGGACCCAA GTCTTCTTCC TGGCGGGCCT CTCGTCTCCT 001280
001281 TCCTGGTTTG GGCGGAAGCC ATCACCTGGA TGCCTACGTG GGAAGGGACC TCGAATGTGG GACCCCAGCC CCTCTCCAGC 001360
001361 TCGAAATCCC TCCACAGCCA CGGGGACACC CTGCACCTAT TCCCACGGGA CAGGCTGGAC CCAGAGACTC TGGACCCGGG 001440
001441 GCCTCCCCTT GAGTAGAGAC CCGCCCTCTG ACTGATGGAC GCCGCTGACC TGGGGTCAGA CCCGTGGGCT GGACCCCTGC 001520
001521 CCACCCCGCA GGAACCCTGA GGCCTAGGGG AGCTGTTGAG CCTTCAGTGT CTGCATGTGG GAAGTGGGCT CCTTCACCTA 001600
001601 CCTCACAGGG CTGTTGTGAG GGGCGCTGTG ATGCGGTTCC AAAGCACAGG GCTTGGCGCA CCCCACTGTG CTCTCAATAA 001680
001681 ATGTGTTTCC TGTCTTAACA AAAAAAAAAA AAAA
>gi|301897529|ref|NR_036444.1| Homo sapiens FOXF1 adjacent non-coding developmental regulatory RNA (FENDRR), transcript variant 2, long non-coding RNA
000001 AGCCCCTAGC GCAGACGGCG GAGAGCAGAG AGGGAGCGCG CCTTGGCTCG CTGGCCTTGG CGGCGGCTCC TCAGGAGAGC 000080
000081 TGGGGCGCCC ACGAGAGGAT CCCTCACCCG GGTCTCTCCT CAGGGATGAC ATCATCCGTC CACCTCCTTG TCTTCAAGGA 000160
000161 CCACCTCCTC TCCATGCTGA GCTGCTGCCA AGGGGCCTGC TGCCCATCTA CACCTCACGA GGGCACTAGG AGCACGGTTT 000240
000241 CCTGGATCCC ACCAACATAC AAAGCAGCCA CTCACTGACC CCCAGGACCA GGATGGCAAA GGATGAAGAG GACCGGAACT 000320
000321 GACCAGCCAG CTGTCCCTCT TACCTAAAGA CTTAAACCAA TGCCCTAGTG AGGGGGCATT GGGCATTAAG CCCTGACCTT 000400
000401 TGCTATGCTC ATACTTTGAC TCTATGAGTA CTTTCCTATA AGTCTTTGCT TGTGTTCACC TGCTAGCAAA CTGGAGTGTT 000480
000481 TCCCTCCCCA AGGGGGTGTC AGTCTTTGTC GACTGACTCT GTCATCACCC TTATGATGTC CTGAATGGAA GGATCCCTTT 000560
000561 GGGAAATTCT CAGGAGGGGG ACCTGGGCCA AGGGCTTGGC CAGCATCCTG CTGGCAACTC CAAGGCCCTG GGTGGGCTTC 000640
000641 TGGAATGAGC ATGCTACTGA ATCACCAAAG GCACGCCCGA CCTCTCTGAA GATCTTCCTA TCCTTTTCTG GGGGAATGGG 000720
000721 GTCGATGAGA GCAACCTCCT AGGGTTGTTG TGAGAATTAA ATGAGATAAA AGAGGCCTCA GGCAGGATCT GGCATAGAGG 000800
000801 AGGTGATCAG CAAATGTTTG TTGAAAAGGT TTGACAGGTC AGTCCCTTCC CACCCCTCTT GCTTGTCTTA CTTGTCTTAT 000880
000881 TTATTCTCCA ACAGCACTCC AGGCAGCCCT TGTCCACGGG CTCTCCTTGC ATCAGCCAAG CTTCTTGAAA GGCCTGTCTA 000960
000961 CACTTGCTGT CTTCCTTCCT CACCTCCAAT TTCCTCTTCA ACCCACTGCT TCCTGACTCG CTCTACTCCG TGGAAGCACG 001040
001041 CTCACAAAGG GCTAATCTCG GGCCTTGTCG AAGGAAGAGG CTGCAGACGT TAATGAGGTT AGCTGCTGGA TTCCAGTATT 001120
001121 CGTCGCATAA GGATCCTTCT TTGTCTGCGA AGGAAAAACA CACTGATTAT CATAATGAGG CACGTGGGCC GTGGCCCGGC 001200
001201 TGGGTCGGCT GAAGAACTGC GGATGGAAGC TGCGGAAGAG GCCCTGATGG GGCCCACCAT CCCGGACCCA AGTCTTCTTC 001280
001281 CTGGCGGGCC TCTCGTCTCC TTCCTGGTTT GGGCGGAAGC CATCACCTGG ATGCCTACGT GGGAAGGGAC CTCGAATGTG 001360
001361 GGACCCCAGC CCCTCTCCAG CTCGAAATCC CTCCACAGCC ACGGGGACAC CCTGCACCTA TTCCCACGGG ACAGGCTGGA 001440
001441 CCCAGAGACT CTGGACCCGG GGCCTCCCCT TGAGTAGAGA CCCGCCCTCT GACTGATGGA CGCCGCTGAC CTGGGGTCAG 001520
001521 ACCCGTGGGC TGGACCCCTG CCCACCCCGC AGGAACCCTG AGGCCTAGGG GAGCTGTTGA GCCTTCAGTG TCTGCATGTG 001600
001601 GGAAGTGGGC TCCTTCACCT ACCTCACAGG GCTGTTGTGA GGGGCGCTGT GATGCGGTTC CAAAGCACAG GGCTTGGCGC 001680
001681 ACCCCACTGT GCTCTCAATA AATGTGTTTC CTGTCTTAAC AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AA
000081 TGGGGCGCCC ACGAGAGGAT CCCTCACCCG GGTCTCTCCT CAGGGATGAC ATCATCCGTC CACCTCCTTG TCTTCAAGGA 000160
000161 CCACCTCCTC TCCATGCTGA GCTGCTGCCA AGGGGCCTGC TGCCCATCTA CACCTCACGA GGGCACTAGG AGCACGGTTT 000240
000241 CCTGGATCCC ACCAACATAC AAAGCAGCCA CTCACTGACC CCCAGGACCA GGATGGCAAA GGATGAAGAG GACCGGAACT 000320
000321 GACCAGCCAG CTGTCCCTCT TACCTAAAGA CTTAAACCAA TGCCCTAGTG AGGGGGCATT GGGCATTAAG CCCTGACCTT 000400
000401 TGCTATGCTC ATACTTTGAC TCTATGAGTA CTTTCCTATA AGTCTTTGCT TGTGTTCACC TGCTAGCAAA CTGGAGTGTT 000480
000481 TCCCTCCCCA AGGGGGTGTC AGTCTTTGTC GACTGACTCT GTCATCACCC TTATGATGTC CTGAATGGAA GGATCCCTTT 000560
000561 GGGAAATTCT CAGGAGGGGG ACCTGGGCCA AGGGCTTGGC CAGCATCCTG CTGGCAACTC CAAGGCCCTG GGTGGGCTTC 000640
000641 TGGAATGAGC ATGCTACTGA ATCACCAAAG GCACGCCCGA CCTCTCTGAA GATCTTCCTA TCCTTTTCTG GGGGAATGGG 000720
000721 GTCGATGAGA GCAACCTCCT AGGGTTGTTG TGAGAATTAA ATGAGATAAA AGAGGCCTCA GGCAGGATCT GGCATAGAGG 000800
000801 AGGTGATCAG CAAATGTTTG TTGAAAAGGT TTGACAGGTC AGTCCCTTCC CACCCCTCTT GCTTGTCTTA CTTGTCTTAT 000880
000881 TTATTCTCCA ACAGCACTCC AGGCAGCCCT TGTCCACGGG CTCTCCTTGC ATCAGCCAAG CTTCTTGAAA GGCCTGTCTA 000960
000961 CACTTGCTGT CTTCCTTCCT CACCTCCAAT TTCCTCTTCA ACCCACTGCT TCCTGACTCG CTCTACTCCG TGGAAGCACG 001040
001041 CTCACAAAGG GCTAATCTCG GGCCTTGTCG AAGGAAGAGG CTGCAGACGT TAATGAGGTT AGCTGCTGGA TTCCAGTATT 001120
001121 CGTCGCATAA GGATCCTTCT TTGTCTGCGA AGGAAAAACA CACTGATTAT CATAATGAGG CACGTGGGCC GTGGCCCGGC 001200
001201 TGGGTCGGCT GAAGAACTGC GGATGGAAGC TGCGGAAGAG GCCCTGATGG GGCCCACCAT CCCGGACCCA AGTCTTCTTC 001280
001281 CTGGCGGGCC TCTCGTCTCC TTCCTGGTTT GGGCGGAAGC CATCACCTGG ATGCCTACGT GGGAAGGGAC CTCGAATGTG 001360
001361 GGACCCCAGC CCCTCTCCAG CTCGAAATCC CTCCACAGCC ACGGGGACAC CCTGCACCTA TTCCCACGGG ACAGGCTGGA 001440
001441 CCCAGAGACT CTGGACCCGG GGCCTCCCCT TGAGTAGAGA CCCGCCCTCT GACTGATGGA CGCCGCTGAC CTGGGGTCAG 001520
001521 ACCCGTGGGC TGGACCCCTG CCCACCCCGC AGGAACCCTG AGGCCTAGGG GAGCTGTTGA GCCTTCAGTG TCTGCATGTG 001600
001601 GGAAGTGGGC TCCTTCACCT ACCTCACAGG GCTGTTGTGA GGGGCGCTGT GATGCGGTTC CAAAGCACAG GGCTTGGCGC 001680
001681 ACCCCACTGT GCTCTCAATA AATGTGTTTC CTGTCTTAAC AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AA
References
- ↑ 1.0 1.1 1.2 1.3 Xu, T. P., M. D. Huang, R. Xia, X. X. Liu, M. Sun, L. Yin, W. M. Chen, L. Han, E. B. Zhang, R. Kong, W. De, and Y. Q. Shu. "Decreased Expression of the Long Non-Coding Rna Fendrr Is Associated with Poor Prognosis in Gastric Cancer and Fendrr Regulates Gastric Cancer Cell Metastasis by Affecting Fibronectin1 Expression." J Hematol Oncol 7, (2014): 63.
- ↑ Grote, P., L. Wittler, D. Hendrix, F. Koch, S. Wahrisch, A. Beisaw, K. Macura, G. Blass, M. Kellis, M. Werber, and B. G. Herrmann. "The Tissue-Specific Lncrna Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse." Dev Cell 24, no. 2 (2013): 206-14.
- ↑ Szafranski, P., Dharmadhikari, A.V., Brosens, E., Gurha, P., Kolodziejska, K.E., Zhishuo, O., Dittwald, P., Majewski, T., Mohan, K.N., Chen, B. et al. (2013) Small noncoding differentially methylated copy-number variants, including lncRNA genes, cause a lethal lung developmental disorder. Genome Res, 23, 23-33.
