HMMR-AS1

From LncRNAWiki
Revision as of 13:44, 19 October 2017 by Jiabao Cao (talk | contribs)
Jump to: navigation, search

Annotated Information

Name

HMMR-AS1:HMMR antisense RNA 1

RP11-80G.1[1]

Characteristics

HMMR-AS1(HMMR antisense RNA 1; RP11-80G.1) is located at 5p34 and is transcribed on the strand opposite to the adjacent HMMR gene which codes for receptor for hyaluronan-mediated motility (RHAMM), a mitotic spindle-binding protein. [1]

Function

[[ Knockdown HMMR-AS1 can impair the proliferation ability and weaken the invasion ability in MDA-MB-231 and MDA-MB-468 cells.[1]

Expression

The HMMR-AS1 expression is markedly higher in BLBCs(Basal-like breast cancers) in contrast to those in non-BLBC subtypes. Besides, the expression levels of HMMR-AS1 and HMMR in the tumor tissue samples are positively correlated(R=0.802, P<0.0001).[1]

Diseases

Basal-like breast cancers [1]

Sequence

>NR_109892.1 Homo sapiens HMMR antisense RNA 1 (HMMR-AS1), long non-coding RNA

000001 AGTCAGCAGC TGACAGAATA ATCCACACAT TGGTTTCCTT ACCTATGGAG TGAGGGCTAT TATGGTGGAA AAGGCCAAGT 000080
000081 AGAAGCCACT AGAACTATCT GTACTTAGGA AAATAGTAAA CCAAAAGCAA TGCTCAATTC CTATAGGGAC TGAAGAGATT 000160
000161 AGTGCCACCA TAAGTACTTG AAGGAAGGCG GGGTGGTGAT TCCTACCATA TGTCCATTCA ACTCGCCTAT TTAGCCTGGG 000240
000241 CAGAAGACAG ATGGATTATC ACAAACTTAA CTAGGTGGTG ACTCCAATTG CAGCTACAGT ACCAGATGTA TTGCTTGAGC 000320
000321 AAATTAACAC AACTCCTGGT TCCTGGTATG CAGCTACCTG GAATCTTGAT TGCCTTTTCT TTCCACATCA CATTGGTCCA 000400
000401 TTACATTGAC GACATTATGC TCACTGGACC TAATGAGTGA GACATAGCAA CTACTCCAGA CCTATTGGAA CTGACTTCAC 000480
000481 CTGCAACAGA GCTTGGAGAA GCTGAAGCCT AAGGGTGCTC TAAAGCAGGG GTCCCCAACC TCCGGGCTAC AGACCAATAC 000560
000561 CCATCCAAGG CCTGTTAGGA ACCCGGCTGC AGAGCAGGAG CTTTTCTGCA TGGAAGAATT AAATTGAGAA AAACATAGTT 000640
000641 ATTTAAAAAA TCACATCGTA ACTGAGTTAA CAAGGCACTC AGGTTCTAAT CATAGATTAC CTTCCTTCTT CATCTTCCAG 000720
000721 CTGTTTTCTA AAGTCTTCCT CCTGTTGCTT GAGTTGGTTC TGCAAATCAG TTATTTTTTG AAGAAAAGAA ACTGTGATTT 000800
000801 CTTTAATTTC TGTTTCCTTT AGTGCTGACT TGGTCTGCAG ATCTAGAAGC ATCCTTTGGT TTGAGAGAGA AGAGGTCACT 000880
000881 AAACATTTTA TAGCCACTTT CATTAATTTT TCCTTTTTTT TTCTTTAAAC CTCAAGGAAC TCTTCAAGAA GTGTCATTTT 000960
000961 TTAACTGAGT AAATTCTTAA TTTGCAGTAT AAGATGGCCA AAAGCAAGCC AAGGGACAGT TACTAGCTGG CTTTCAACAT 001040
001041 TAAATTGTCT TAATGGTTCT AAGGCCATTA TTTGCTCTAT ATACCTTACA TATTCTTGAT TTGAGCTCTC AGTTGCCAAA 001120
001121 ATCTGATGCT GAACATCCTC TGCATTTTTC CCAGCCTTGG CCGCTTTTTC CTGTAATGAT GAGTTCTCCA GCTTAAGATC 001200
001201 TTCTATCTCA CTGGCTGTTA ACGCTTTATA GCTTATTAAA AAGAAAAAAA AGTCAAAGTA GTTTTCTAA

Labs working on this lncRNA

  • Department of Radiation Oncology, Anhui Provincial Hospital, Hefei, People's Republic of China.

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Liu W, Ma J, Cheng Y, Zhang H, Luo W, Zhang H. HMMR antisense RNA 1, a novel long noncoding RNA, regulates the progression of basal-like breast cancer cells. Breast Cancer (Dove Med Press). 2016 Nov 24;8:223-229.
Retrieved from "https://ngdc.cncb.ac.cn/lncrnawiki1/index.php?title=HMMR-AS1&oldid=1273725"