Difference between revisions of "LIF-AS1"

From LncRNAWiki
Jump to: navigation, search
Line 1: Line 1:
 +
 
==Annotated Information==
 
==Annotated Information==
===Approved Symbol===
+
===Name===
LIF-AS1
+
LIF-AS1:LIF antisense RNA 1
===Approved Name===
+
 
LIF antisense RNA 1
+
ENST00000447565 <ref name="ref1" />
===Previous Symbols===
+
===Characteristics===
_
+
ENST00000447565 is a LIF (leukemia inhibitor factor) natural antisense lncRNA. <ref name="ref1" />
===Synonyms===
+
 
Lnc-LIF-AS
+
===Function===
===Chromosome===
+
Lnc-LIF-AS can regulate the stability of LIF mRNA by over-lapping a 3′-UTR of LIF mRNA which might contribute to inhibit the degradation of LIF mRNA mediated by other RNAs.<ref name="ref1" />
22q12.2
+
===Regulation===
===RefSeq ID===
+
The expression ofΔNp63α can directly inhibitLIF mRNA transcription and decrease LIF mRNA stability by suppressing the expression of Lnc-LIF-AS.<ref name="ref1" />
_
+
===Diseases===
===OMIM ID===
+
Cervical squamous cancers<ref name="ref1" />
_
+
===Expression===
===RefSeq(supplied by NCBI)===
+
ENST00000447565 is significantly downregulated expression  in SiHa/ΔNp63αstable cell lines.
_
+
In addition, Lnc-LIF-AS is also shown gradually up-regulated with the increase of ΔNp63α siRNAs. <ref name="ref1" />
===pubmed IDs===
+
 
28391028
+
==Labs working on this lncRNA==
===Disease===
+
*Department of Obstetrics and Gynecology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China.
Cervical squamous cancers
+
==References==
 +
<references>
 +
<ref name="ref1">
 +
Qian L, Xu F, Wang X, Jiang M, Wang J, Song W, Wu D, Shen Z, Feng D, Ling B,
 +
Cheng Y, Xiao W, Shan G, Zhou Y. LncRNA expression profile of ΔNp63α in cervical
 +
squamous cancers and its suppressive effects on LIF expression. Cytokine. 2017
 +
Aug;96:114-122.
 +
</ref>
 +
</references>

Revision as of 02:38, 13 August 2017

Annotated Information

Name

LIF-AS1:LIF antisense RNA 1

ENST00000447565 [1]

Characteristics

ENST00000447565 is a LIF (leukemia inhibitor factor) natural antisense lncRNA. [1]

Function

Lnc-LIF-AS can regulate the stability of LIF mRNA by over-lapping a 3′-UTR of LIF mRNA which might contribute to inhibit the degradation of LIF mRNA mediated by other RNAs.[1]

Regulation

The expression ofΔNp63α can directly inhibitLIF mRNA transcription and decrease LIF mRNA stability by suppressing the expression of Lnc-LIF-AS.[1]

Diseases

Cervical squamous cancers[1]

Expression

ENST00000447565 is significantly downregulated expression in SiHa/ΔNp63αstable cell lines. In addition, Lnc-LIF-AS is also shown gradually up-regulated with the increase of ΔNp63α siRNAs. [1]

Labs working on this lncRNA

  • Department of Obstetrics and Gynecology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China.

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Qian L, Xu F, Wang X, Jiang M, Wang J, Song W, Wu D, Shen Z, Feng D, Ling B, Cheng Y, Xiao W, Shan G, Zhou Y. LncRNA expression profile of ΔNp63α in cervical squamous cancers and its suppressive effects on LIF expression. Cytokine. 2017 Aug;96:114-122.