LINC00672

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Annotated Information

Name

LINC00672:long intergenic non-protein coding RNA 672

Characteristics

LINC00672 possesses an ultra-conserved region, is aberrantly downregulated during the development of endometrial carcinom(EC). [1]


Function

LINC00672 is a p53-targeting lincRNA actingalongwith hnRNPs as a suppressive cofactor, which locally reinforces p53-mediated suppression of LASP1, an evolutionarily conserved neighboring gene of LINC00672 and putatively associated with increased tumor aggressiveness,during antitumor processes. LINC00672 overexpression could lower the levels of LASP1 and slow the development of malignant phenotypes of EC both in vitroand in vivo. Moreover, LINC00672 significantly increases the 50% inhibitory concentration of paclitaxel in EC cells and increases the sensitivity of xenograft mice to paclitaxel. [1]

Regulation

The absence of p53 influences the expression of LINC00672 in uterus.[1]

Diseases

Endometrial cancer [1]

Expression

The results shows that the expression levels of LINC00672 are significantly higher (~4.15-fold,P<0.001) in adjacent non-neoplastic tissues (N) than in tumor tissues. [1]

Sequence

>NR_038847.1 Homo sapiens long intergenic non-protein coding RNA 672 (LINC00672), long non-coding RNA

000001 CACGAAACTT TTGTCTGTGT CTCCCCATAA TGTGACCTTT AGAAGTTGCC AATGGCCCAC CCAATACCCA ACCATGATTT 000080
000081 TTCTGAGATA ATCTGCCCGA GGTGTGTGAG AGGAAACGCG AAGAAGGCAG TCAGGAGGAT TCACTCTTGG GGGAGCTGGG 000160
000161 TAGGATCCTA TCTCCTCCTA CATCCAGAGC ATGCAGGCTC CATTTAGATA CAAAGGGGTG GGATTGGGTT CCTGGGGAGA 000240
000241 AATTGAGCCC CTTTGATTCT GCGGTTCTGT GGGTCTAAAT CTGGCATCTC CTTGGCTATC CACCCCCAGG CTTTGTGATT 000320
000321 GGTTGGCTGT GGTTGGTGGG GGGGCAGGAA GCTGCTGGTG GAGCTGCAGC ATCCTTCAGT CTCAGGCCCC TGGGAGGGGG 000400
000401 AGGGGAAAGA ACCAGGGCTG AGCTGTGGAG TGAAGGGGAG CCATTTCTCT CCACCGACTG CAACCTCCGT GCTCACAGCT 000480
000481 CACGGTTCAC CAGAATCCAG GGGCTTGGTC GGCCTAGGAA TCCACAATGC TGGATATTTT CATCCTGATG TTCTTTGCCA 000560
000561 TCATAGGCCT GGTCATTCTG TCCTACATTA TCTATCTGCT CTAGTGGCCT GGAGCTGCGG CCGGAGCCTG CTGGAGAACA 000640
000641 GCTCAGAAGG AAGGATGGAG ATGAATGGCC GAGTGCCCTG CTTGCTGACG CACCGGTGGA TTTTTGCTTC TGCTGTTATC 000720
000721 TCGGCTCCTG GTCTCTCCAG TCCAACAAGA GGCCTCTCAT CCACAGAAGC AGTCCTACTG CCCAGCAGAC CTCTTTCAGA 000800
000801 GCCTTCCAGA CATGGCTGAC CCCTGGCAAG CAAGGGGCTT TTTGAGCTGA GAGGCACTTG GCTGGGACTT CAGGAATTCA 000880
000881 TGGACAGGGC TGGCAGATAC TGCATATGTT TGAGCTGTAG ATGGGATTGA GAACAGAAAG TTGAAATGGA GACTTATTAA 000960
000961 AGTTACCGTG GAGAACTGCT CAAAAATTCA TTTTGAATTA AGGAAACTTA AATTCATTTT AAGTTTCCTT AGATCTAAAT 001040
001041 GCAACTGCAC ATTACACTCA AATATGTTCC TTCCTTCTCA CACACAGGAC TCCCTTGTGA AACTCAAGGG GAAGTTCAAG 001120
001121 TTGTCCATCT TCATCTATGA AGTAGTCACT TTATCACTGT CTTTACAGAT TGCACAGTCT GGGGTTTTGT GGTTTCTCTT 001200
001201 GTCTCACTCT CCAGCCAGGA AGAACTTGTC ATTTGAGTTT TTAAAATGTA TCATTTCTTC CCCACCTCAA ACCACTTGTA 001280
001281 TCCCAGTTTC TCATTTAAAG GGAGAAATGG TTATATAGTC CTCTCTTTGC ACCTGATTGA ATTATAAATG ATAGAAACAA 001360
001361 GATGGCTATA CTTATTTAGG AAAAATCTCT TACCCCAAAA TGAGTGTGTG TGTGTGTGTG TGTGTGCGTG TGTGTGTGTG 001440
001441 TGTGTGTTTT AATCAAAGAT CTTTTCTGGA AAAAACTTTC CACATAGTTC TCTGACCCAT TAGAGTTGAA GAAACTATGT 001520
001521 ATTTTGGGAT TCAGAGTAGA ATTGGCCTGC AAATCTGGGG TGTTTATTCC TTTTACAAGT CTATCATAAT TGTTCTACAT 001600
001601 TTAATTTTCC TTTCTTGCTT AAAAGTAAAC AAGGAGAGTC AGGAGTGGTG GCTCATGCCT GTAATCCCAG CACTCTGGGA 001680
001681 GGCCGAGGCG GATGGATCAC CTGAGGTCAG GAGTTGGAGA CCAGCCTGGC CAACACGGTG AAACCCCGTC TCTACTAAAA 001760
001761 ATACAAAAAT TAGTCAGGCA CAGTAGTGCG CGCCTGTAGT CCCAGCTACC CGGGAGGCTG AGGCCGAAGA ATTGCTTGAA 001840
001841 CCCGGGAGGC AGAGGTTGTA GTGAGCCGAC ATCATGTCAC TGCACTCCAG CCTGGGAGAC ATAGCGAGAT TCCGTCTCAA 001920
001921 ATAAAATAAA ATAAATAAAT AAATAAACAA GGAGAAAGAT TAGTTTTTAG TAATAACATT GTGTCCAATT TCCATGTTTT 002000
002001 AAAACAAAAA TTGAGGCATT ATATGTCACA ACTGAAATGG AAAAGTTGTG TTTAAAAATT ATGGACAAGG CCGGGCACGG 002080
002081 TGGCTCACGC CTGGAATCCC AGCACTTTGG GAGGCTCAGG CAGGAGGATC ACTTGAGGTC GGGAGTTTGA GACCAGTCTG 002160
002161 ACCAACGTGG TGAAACCCTG TCTCTACTAA AAATACAAAA ATTAGCTGGT GTGGTGGCAG GTGCCTGTAA TCCCAGCTAC 002240
002241 TCAGGAGGCT GAGGCAGGAG AATCGCTTGA ACCTGGGAGG CAGAGGTTGC AGTGAGCCGA GATCACACCT CTGCACTCCA 002320
002321 GCCTAGGTGA CACAGCAAGA CCCCATCTCA AAAAAAAATA ATAATAAAAA CATAAAAATT ATGGACAAGA AAAAACACTA 002400
002401 TTCTGGAAGC TTTGTTTTGG CAACAAATTA TATGACCTGA CCTTTCATAA GTCATTTAAA CTTTAGGGCT AGGCCAGGTG 002480
002481 CTATGGCGCA TGCCTATAAT CCCAGCATTT AGGGAAGTAG AAGCAGGAGG ATAGCTTGAG GCCAAGAATT CCAGACCAGC 002560
002561 CCAGGCAATA TAGCGAGACC CCCGTCTCCA CAAAAATAAA AAATAAAATA AAAATAAATA AATACATAAA CTTTAGGTCC 002640
002641 TCTGTTTATT CTGTCAAATG AAAGTGTTAG GCCAAGGTCG CATTATCTCT TTGGAAACTA CATCGAGAAC AGAATTCCCA 002720
002721 TGGAACGAAC TCTTAATAGT TCACTGGTAG TCCCCCTTTT CTGAATATTC TTCCCAACAT GACACTTTAT AACAAAAATT 002800
002801 TAACTGCAAA ACTCTTTTTT TTTCACCAAC AGCCAGATTT TGATGAGAAA ATGGCCATAT TTATTTACTC CAAATATATA 002880
002881 TTATGTCTGT GATAATTTGC CTAAACTGTT TAAGGAATAT TAACAAGTAT GATACTGCAT CGTGGTATGT AGCAAAAAGA 002960
002961 TAGGTAATCT GACATACATG GATGCAAGCA GCATGGCTGT GAACCTGGAT ATATTTAGAA ATGATCTTCA GTGGAGTCCT 003040
003041 TGATGTGACA TTTTCCACTA AAACATTCTT CTAACTCTGG TATATCTTAG TGTTTCGAAC TATAATTTCC GTCTTCAAGC 003120
003121 CAAGACAGCA GCTCTACATC CTTACCTAGG TAATTCAGGC ATGCGCCAGT ATTTTGGAGG GGTCCAAATT AGAGTTAGTT 003200
003201 ATGATGGTAT AGATCTTTAA AGTATAGTCT AACCAAGCTT GCTCTGGTCT TTTGTGACAT CAAGGCTTCT CAGTCTGTAT 003280
003281 TCACATAAAG TTGAAACAAC TAATCAATTC AGTGAAAAAA AATCAGCAGA TTTCACTCAT ACACTGGTGA TATATACCAC 003360
003361 TGGTATTGGG TACAATGTAA GGAGAGAGGA TTACCCATCT CTTCAGTTAC TTGTAAAATA TGATTTTAAA AAAATAAATC 003440
003441 AATACATTTT GGAAAAATTA TATGACTTTG TGCTTATATT TATGCAACAA TATGCTAGCT TATAACAGGG TTTTACTGTG 003520
003521 TTATTTTGAT AGTTGTTTAA ATTTTACATT TAAACTATTT GTATTTTGGC ATCCCAAAAC ATAATAAAAC ACTGCAAAAA 003600
003601 GTTACCTCTG TAATATAAGA TTTTGTATAA ATTTTATAAA TTTGTGTCAT AGGGTAATTT TGTCCAATAA AATGTCAATG 003680
003681 AGATAAAAAC CAAAAAAAAA AAAAAAAA

Labs working on this lncRNA

  • From the Department of Genetics, Medical College of Soochow University, Suzhou 215123.

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Li W, Li H, Zhang L, Hu M, Li F, Deng J, An M, Wu S, Ma R, Lu J, Zhou Y. Long non-coding RNA LINC00672 contributes to p53 protein-mediated gene suppression and promotes endometrial cancer chemosensitivity. J Biol Chem. 2017 Apr 7;292(14):5801-5813.
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