LINC01116
Contents
Annotated Information
Name
LINC01116:long intergenic non-protein coding RNA 1116
TALNEC2 [1]
Characteristics
TALNEC2 (Tumor Associated Long Non-coding RNA Expressed on Chromosome 2) is a 1,407 bp long intergenic lncRNA (localized between genes in a nonprotein-coding region) that is located on the reverse strand and consists of three exons.[1]
Cellular Localization
TALNEC2 is localized to the cytosol.[1]
Function
Knockdown of LINC01116 resulted in a significant increase in GAPDH, MAP1LC3B2, H2AFY and UBA52 expression at the mRNA level. LncRNA in prostate cancer wherein it contributes to suppression of key genes known to regulate glycolysis, autophagy and chromatin structure. [2] Silencing of TALNEC2 inhibits cell proliferation, arrests the cells in the G1\S phase of the cell cycle in various cancer cell lines, decreases the self-renewal and mesenchymal transformation of GSCs, increases sensitivity of these cells to radiation and prolongs survival of mice bearing GSC-derived xenografts. [1]
Regulation
TALNEC2's expression is E2F1-regulated and cell-cycle dependent.[1]
Disease
- Prostate cancer.[2]
- GBM[1]
Expression
TALNEC2 is highly expressed in GBM with poor prognosis, in GBM specimens derived from shortterm survivors and in glioma cells and glioma stem cells (GSCs).[1]
Sequence
>NR_040001.2 Homo sapiens long intergenic non-protein coding RNA 1116 (LINC01116), long non-coding RNA
000081 CTTGCCTCCC CTTACCCCGA AAGCCCCGCT CAGTTCAATA TTTCAAGTGA AAATCTGCCT GTTCGAAAAG AAAATATTCA 000160
000161 CAAATGAGCA GTGTATTAGA AGACAACTGA ATTGCTTCTA AGAATGGGTC TCACTCTGCC ATCACCCAGG CTGGAGTGTG 000240
000241 GTGGCACCAT CATGGCTCAC TGCAGCCTTG AACTCCTGAG CTCAAGTCAT CCTCCCACCT CAGCCTTCCG AGTAGCTGGA 000320
000321 ACTGCAGGTG TGAGCCACCA TGCCTGGCTG ATTTGTCTTT TTAAATTTTT TATAGAGACC GAGTCTCAAC TATATTGTCC 000400
000401 AGGCTGGAAA AGAACTTCTT TCCCTCCAAG TGATAACCTT TTCCAGACAA GTCAGCTTAA AAACTGACCC AAAGGCCCTG 000480
000481 AAGTACACAG TTTTCTTGGA GAAAGAAAAA AATAAGTGAA AAGGACTTGC TGACTTGCTA ATTCATTTTG GGGCCTGTGG 000560
000561 GTAACATCAG AATGGCAAAG CACTTGGGGC TTTTTTCTAA TTTGTATTTT TTTAATCTTC TGAGAAATGA CTTTTATATG 000640
000641 CCAAGATTCA TTCCATGATT AGTTTTTATG ACCAAGTTAT GAACGCTTTT GAATATGGGG ACCTAGAATA GAAATGCTAA 000720
000721 CCTACCTGCA AGGAGAGCTC TGTGATTGGC ATCCCCATCA TGCTGTAACT GACACAAAAT AAACTTAGGG TAATTGCCGC 000800
000801 ATAGTGTAAC TTTAATGTGT GAGCATACTG TAACATCTGA CAAGCTTCTT GATCTAGATC AGCAATGTGT AACCCATTCA 000880
000881 TTGTTGTCAC TCTCAACAAG GCCTTATGGT CAAACATCAT CACTCTCACT AAAGAGATAG TTTACTGAAA TATACTGAGA 000960
000961 TTTTGAAACT GGAGTCAAGA GGTAGCACAC TGTTTTATGT TGATCCATTT AATGGTCCTT GACAGCCAAT AAAAAGACAC 001040
001041 TGGAAGAATA CGTGAATG
Labs working on this lncRNA
- Biological and Population Health Sciences, Oregon State University, 103 Milam Hall, Corvallis, OR 97331
- Linus Pauling Institute, Oregon State University, 307 Linus Pauling Science Center, Corvallis, OR 97331
- Department of Biochemistry and Biophysics, Oregon State University, 2011 Agriculture and Life Sciences Building, Corvallis, OR 97331
- Department of Botany and Plant Pathology, Oregon State University, 2082 Cordley Hall, Corvallis, OR 97331
- Center for Epigenetics & Disease Prevention, Institute of Biosciences & Technology, Texas A&M Health Science Center, 2121 W. Holcombe Blvd., Mail Stop 1201, Houston, TX 77030-3303
- Center for Genome Research and Biocomputing, Oregon State University, 3021 Agriculture and Life Sciences Building, Corvallis, OR 97331
- Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, 105 Magruder Hall, Corvallis, OR 97331
- Environmental and Molecular Toxicology, Oregon State University, 1007 Agriculture & Life Sciences Building, Corvallis, OR 97331
- The School of Electrical Engineering and Computer Science, Oregon State University, 1148 Kelley Engineering Center, Corvallis, OR 97331
- Moore Family Center, Oregon State University, 103 Milam Hall, Corvallis, OR 97331[2]
- Everard and Mina Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
- Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Detroit, MI, USA
- Department of Public Health Sciences, Center for Bioinformatics, Henry Ford Hospital, Detroit, MI, USA[1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Cite error: Invalid
<ref>tag; no text was provided for refs namedref2 - ↑ 2.0 2.1 2.2 Beaver LM, Kuintzle R, Buchanan A, Wiley MW, Glasser ST, Wong CP, Johnson GS, Chang JH, Löhr CV, Williams DE, Dashwood RH, Hendrix DA, Ho E. Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer. J Nutr Biochem. 2017 Apr;42:72-83.
