LINC01826

Annotated Information

Name

LINC01826:long intergenic non-protein coding RNA 1826

lnc-MKI67IP-3

Cellular Localization

Lnc-MKI67IP-3 is primarily localized in the cytoplasm .

Function

Lnc-MKI67IP-3 could bind to let-7e as a miRNA sponge .

These results indicate that Lnc-MKI67IP-3 might play important roles in the inflammatory responses of VECs and development of atherosclerosis . Lnc-MKI67IP-3 acts as a sponge or competing endogenous RNA (ceRNA) for let-7e, suppressing its pro-inflammatory effects, and let-7e decreased lnc-MKI67IP-3 expression, thereby forming a positive feedback loop to aggravate inflammation . Moreover, lnc-MKI67IP-3 is also abnormal in oxLDL-treated VECs and atherosclerotic plaques .

Regulation

Let-7e mimic significantly down-regulate lnc-MKI67IP-3 expression, while let-7e inhibitor markedly up-regulate this expression and let-7e inhibitor could be considered as an inducer of lnc-MKI67IP-3, just like vitamin C .

Expression

In human umbilical vein endothelial cells (HUVECs) treated with ox-LDL for different times, lnc-MKI67IP-3 is significantly down-regulated .

Diseases

Inflammatory response in vascular endothelial cells, atherosclerosis

Sequence

>XR_001739207.1 PREDICTED: Homo sapiens uncharacterized LOC107985818 (LOC107985818), ncRNA

000001 CTGAACGCTA AGAACAACAG AACGTAAGAC TGACAGTTGA CTTATCATAA TGATATCCTT CTTTCCCATT GAAAAAATGT 000080
000081 AGTTGATGAG AAGTGTCTGC TTCCATTGCC CGTGAATCCC TAACAGAATG GTGCCAGGCT CCACCAGGAG ACCTTCCTGA 000160
000161 GTCCCATCTG AAAGCCTCCA CCTGAATGCG TCCCTCATTT TAATGACCCA GCCAGGCTAC CTCTGAAGAG AAGGGCAGTT 000240
000241 CTCAGCAGCC TGAGGGGTGC TGGTAGAGAC ATACCAAAAG TGTTGTTGGT GCCACCTTTT TGCAAGAGAT GAAGAGAAAG 000320
000321 TTCC

Labs working on this lncRNA

• The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Ministry of Public Health; The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine; Qilu Hospital, Shandong University, Jinan, China.