LINC01857

Annotated Information

Name

LINC01857：long intergenic non-protein coding RNA 1857

AC079767.4

Characteristics

The long non-coding RNA transcript AC079767.4 (Ensembl ID ENST00000429730) is encoded by gene AC079767.4 (Ensembl ID ENSG00000224137)

Function

The C allele of rs12477677 within the lncRNA AC079767.4 gene seems to possibly pose a relatively weak protective effect for the development of tuberculosis. And the variants in lncRNA AC079767.4 are most likely related to inter-individual differences in host defense response to Mycobacterium tuberculosis (MTB) infection.

Diseases

Tuberculosis

Expression

According to microarray analyses conducted by Yi Z. et al., the long non-coding RNA transcript AC079767.4 is differentially expressed in the active tuberculosis group, latent tuberculosis infection (LTBI) group and healthy control group. And AC079767.4 transcript is down-regulated in both the active TB group and LTBI group compared with healthy controls, and its expression level is elevated in the LTBI group when compared to the active TB group

Sequence

>NR_135567.1 Homo sapiens long intergenic non-protein coding RNA 1857 (LINC01857), transcript variant 2, long non-coding RNA

000001 GAGGATGCAG TGTTCATGAA AGCAAACACT GGGCCCTCAC CAGGCAACAA ACCTGCTGGT GCCTTCATCT TGGACTTCCC 000080
000081 AGCCTTCGGA ACTATGGAGC CCGCACTCTC CAGTTCATCA CCACCCCAGC ATCCCTACTC TTGCATCTAA CAGTTTCCGC 000160
000161 TATTTTGCAC CACCTGCCTG GCCCTTATGG GCAACTCAAG GAAGAAAGGA AAGAAGAGAT AGAGGAAAAA TGGATTCAAC 000240
000241 AAATGAAAGT GTTCTTTCTG ACTACTGCTG TGTTTACAAA CATTTTAATC ATCAAAACAT GCTTTATTTG ATAGAAAGAT 000320
000321 CAAATCTGCC TTTGTAAAAC AAGAGACTAT TTTAATCATT AAGACAACAC ACATGTTTGA TTTGGAGGCG TGTTCTCATT 000400
000401 CAAAACCTTG CAAAATATAA TTTCTTCTTG TCTGGGA

Labs working on this lncRNA

• Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610041, P.R. China.