Lnc-APBA1-3:1
BANCR, BRAF activated non-coding RNA,a 693-bp transcript on chromosome 9, actively functions as a regulator of EMT during non-small cell lung cancer(NSCLC) metastasis.
Contents
Annotated Information
Name
BANCR: BRAF-activated non-protein coding RNA (HGNC nomenclature) LINC00586[1]
Function
BANCR inhibits migration and invasion of NSCLC cells and induces apoptosis, which possibly also affected EMT[1].
Downregulation of BANCR may be a negative prognostic factor for NSCLC patients, and indicative of poor survival rates and a higher risk for cancer metastasis[1].
Regulation
Histone acetylation is a key factor in controlling lncRNA BANCR expression[1].
Expression
BANCR is overexpressed in melanoma cells and crucial for melanoma cell migration. Specifically, BANCR expression was significantly lower at the later stages of tumor development, and in tumors that had undergone extensive metastasis[1].
| Primer | Sequence(5'-3') |
|---|---|
| BANCR F | ACAGGACTCCATGGCAAACG[1] |
| BANCR R | ATGAAGAAAGCCTGGTGCAGT[1] |
| si-BANCR | GGAAAUAGACUGCAGCACCAATT[1] |
Diseases
Labs working on this lncRNA
- Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing 210029, People's Republic of China. [1].
- Department of Orthopedics, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.[2].
- Department of Gastroenterology, Qi-Lu Hospital, Shandong University, Jinan, 250012, Shan Dong Province, People's Republic of China.[3].
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Sun M, Liu XH, Wang KM, Nie FQ, Kong R, Yang JS, et al. Downregulation of BRAF activated non-coding RNA is associated with poor prognosis for non-small cell lung cancer and promotes metastasis by affecting epithelial-mesenchymal transition[J]. Molecular cancer. 2014,13:68.
- ↑ 2.0 2.1 Peng ZQ, Lu RB, Xiao DM, Xiao ZM. Increased expression of the lncRNA BANCR and its prognostic significance in human osteosarcoma[J]. Genetics and molecular research : GMR. 2016,15(1).
- ↑ 3.0 3.1 Zhou T, Gao Y. Increased expression of LncRNA BANCR and its prognostic significance in human hepatocellular carcinoma[J]. World journal of surgical oncology. 2016,14(1):8.
Basic Information
| Transcript ID |
lnc-APBA1-3:1 |
| Source |
LNCipedia2.1 |
| Same with |
NONHSAT131775,BANCR,LINC00586 |
| Classification |
intergenic |
| Length |
722 nt |
| Genomic location |
chr9-:71911594..71922016 |
| Exon number |
4 |
| Exons |
71911594..71911783,71919852..71919993,71921064..71921206,71921770..71922016 |
| Genome context |
|
| Sequence |
000001 GAACAGCCCA TGCTGCTGCT CTGCCTATGG AGTAGCCATT CTTTATTCCC TTACTTTCTT AATAAACTCG CTTTCACTTT 000080
000081 ATGGATTCAA CTGTAATTCT TTCTTGTGTG AGATCCAAGA ACCTTCTTGT AGGGTCTGGA TTGGGACCCT TTTCTGGTAA 000160 000161 CATCTTCCTG GTGACCATGA AGGGACAATA CTGAAGAGAC CCCTGACCCT AAGGAAATAG ACTGCAGCAC CAATGGGCCA 000240 000241 ACTTTGGGGC GATCATCTTG CCCAGAAACA TCATGTTGAA ACTCTTGGTC AGAGGTTGGA TGAAAGCTGA CAGGGTCCAT 000320 000321 CCAGGAGCAA GTTTGAGCCT TGCCAGTTCC ATTTTGGGTG CTGAGTGGAG TGGCGACTAT AGCAAACCTG TGATCTCTGG 000400 000401 CTGCTGCTCA GAAGAAACAA GAGGGAGGGA TGAATAATGT AAAACTCTGG ATCAATATTC TAATTCTGAG CCTCTATTGG 000480 000481 AATCAGCTAG CAACCACATA TCAGCTTGGT TTCAACAGTT TCCCAGTTCA TGCTGCTGAG AAGTTCAGAG TCAAACCTGA 000560 000561 ATCTCACCTC TGCAAAGAGC ACAGGACTCC ATGGCAAACG TTGTATATAC GCAAGTCATC CCTGGCACCA CATTGATTTA 000640 000641 CTGCACCAGG CTTTCTTCAT TGTGATGATG TTCTCTCTCT TTTCTAAAAA AAAAATAAAA ATAAAATTTA AAAAATCCTG 000720 000721 TT |
