Difference between revisions of "MGAT3-AS1"

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===Synonyms===
 
===Synonyms===
 
TapSAKI
 
TapSAKI
===Disease===
 
acute kidney injury
 
 
===Chromosome===
 
===Chromosome===
 
22q13.1
 
22q13.1
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===Characteristics===
 
===Characteristics===
MGAT3-AS1 is an intronic antisense lncRNA, which is transcribed from a gene located in the genome on chromosome 22.<ref name="ref1" />
+
MGAT3-AS1 is an intronic antisense lncRNA, which is transcribed from a gene located in the genome on chromosome 22 <ref name="ref1" />.
  
 
===Expression===
 
===Expression===
MGAT3-AS1 was significantly increased in these patients compared to healthy controls and disease controls.<ref name="ref1" />
+
MGAT3-AS1 is significantly increased in patients with acute kidney injury (AKI) compared to healthy controls and disease controls <ref name="ref1" />.
  
 
===Function===
 
===Function===
MGAT3-AS1 can predicts the survival of AKI and thus has the biomarker potential of AKI (P <0.001).<ref name="ref1" />
+
MGAT3-AS1 is an independent predictor of 28-day survival (P < 0.01), and it is enriched in tubular epithelial cells subjected to ATP depletion (P = 0.03) <ref name="ref1" />.
MGAT3-AS1 is specifically enriched in hypoxic renal tubular epithelial cells.<ref name="ref1" />
+
 
 +
===Disease===
 +
acute kidney injury <ref name="ref1" />
  
 
==Labs working on this lncRNA==
 
==Labs working on this lncRNA==

Revision as of 08:19, 7 December 2017

Annotated Information

Approved Symbol

MGAT3-AS1 (MGAT3 antisense RNA 1)

Synonyms

TapSAKI

Chromosome

22q13.1

RefSeq ID

NR_126469

Ensembl ID

ENSG00000227188

Characteristics

MGAT3-AS1 is an intronic antisense lncRNA, which is transcribed from a gene located in the genome on chromosome 22 [1].

Expression

MGAT3-AS1 is significantly increased in patients with acute kidney injury (AKI) compared to healthy controls and disease controls [1].

Function

MGAT3-AS1 is an independent predictor of 28-day survival (P < 0.01), and it is enriched in tubular epithelial cells subjected to ATP depletion (P = 0.03) [1].

Disease

acute kidney injury [1]

Labs working on this lncRNA

  • Institute of Molecular and Translational Therapeutic Strategies (IMTTS) and Department of Medicine/Division of Nephrology and Hypertension, Hannover Medical School, Hannover,[1] Germany.
  • Institute of Molecular and Translational Therapeutic Strategies (IMTTS) and National Heart and Lung Institute, Imperial College London, London, UK. lorenzen.[1]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Lorenzen, J.M., et al., Circulating long noncoding RNATapSaki is a predictor of mortality in critically ill patients with acute kidney injury. Clin Chem, 2015. 61(1): p. 191-201.

Sequence

>gi|704000385|ref|NR_126469.1| Homo sapiens MGAT3 antisense RNA 1 (MGAT3-AS1), long non-coding RNA

000001 GCTACTGGTG GTCATCGGGG ACGCAGATAT GTGTGTCTCC ATTTTGCAGA TGAGGACATG GAGGCCTCAA GAGGTTAAGT 000080
000081 GACTTGCTCA GCCACACACA GCTGATGGGA ATGAAACAGA CGGAAACGGA GACTCCCCAA GCTGACAGGC GGACTACAGA 000160
000161 TCTGGGGGTT CTGCTCCAGG CTCAACACAA GTGGCCTGGG CGAGGGAGGG CCTGGTAGAC CATGACACCC AGCATCGAGG 000240
000241 AATTCTGCTT CCCCAGCAGG CTCAGAAGGA AGAAGTCTGC TTCAGGGGCC AGGCCTGGTC AAAGACTCCA TCTTCCCTGG 000320
000321 ATGGCCAGAG TCAAATCCTT GCAAATCCCG TTCACCATGG AGCAGAGACG AGACCTATGT TACCCAGGCT GTATGTGAAT 000400
000401 TCCTGGACTC AAGCAATCCT CCCATCTCAG CCTCGTGAGT AGTTGGGACA AGTCTCACAC CACCATACCC AGCTTAATTT 000480
000481 AATTTGAATT TTAATAGC