MPPED2-AS1
MPPED2-AS1, and its associated gene MPPED2 are down-regulated in Human Thyroid Neoplasias and act as tumour suppressors
Contents
Annotated Information
Approved Symbol
MPPED2-AS1
Approved Name
MPPED2-AS1: MPPED2 antisense RNA 1 RP5-1024C24.1
Characteristics
LncRNA MPPED2-AS1 is located on chromosome 11 in antisense position with respect to the MPPED2 gene encoding a metallophosphoesterase protein. MPPED2-AS1 and MPPED2 are co-regulated during the process of thyroid carcinogenesis.
Function
MPPED2-AS1 is able to affect cell growth and migration in thyroid carcinoma cells, It was that the restoration of RP5-1024C24.1 is able to increase PTEN protein levels and to reduce Akt-Ser473 phosphorylation, thus suggesting that the modulation of this pathway could account for the effects of MPPED2-AS1 on cell proliferation and migration
Regulation
NA
Diseases
- Thyroid Carcinogenesis
Expression
Expression levels of MPPED2-AS1 are decreased in both differentiated and undifferentiated thyroid carcinomas
Labs working on this lncRNA
- Institute of Experimental Endocrinology and Oncology (IEOS) "G. Salvatore", National Research Council (CNR), Via Sergio Pansini 5, 80131 Naples, Italy. simona.pellecchia@unina.it.
- Department of Molecular Medicine and Medical Biotechnology (DMMBM), University of Naples "Federico II", Via Sergio Pansini 5, 80131 Naples, Italy. simona.pellecchia@unina.it.
- Service d'Anatomie et Cytologie Pathologiques, Centre de Biologie Sud, Groupement Hospitalier Lyon Sud, 69495 Pierre Bénite, France. pserra54@gmail.com.
References
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Sequence
>gi|105376609|ref|XR_931156.3|PREDICTED: Homo sapiens uncharacterized LOC105376609 (LOC105376609), transcript variant X1, ncRNA
000001 GTCTCCAGCA CTGCGGACAC CCGGGTGACA CATTCTTTCG GAGAGGGAGG GCAAGACTTT TCTCCGGAGC CTCTGGCAAC 000080
000081 TCGTGGAGTC TATATAAGAT CTTCAAAGAA AGAGATATCC TTTCGAGGCA ACACAAGAAG CCAACTACAA ATGAGAATAT 000160
000161 TATTCTCTTG GTGCAGGGAT TGTTGCATGT GGACCCCATC AGCCTTGAAA AGTCCATGCA ATGGAGTGAA ACTTGACAAA 000240
000241 GCAGTTGCAG TCGTTCACCA GTGAAGCAAA GTCTTCTTCC TAGTCACGCA GGAATTTTTT TGGGGGAGAT AACTTGATGC 000320
000321 CTGGAGCTGC TGCTGCATCT TATGTAAATG ACAACTAAGG ATAAAAACCA CACACATTAC CCAAGGTGCA GTAAAAGAAG 000400
000401 ATATTTTGGG AGGAAGAGAG AAAGCAAGAG AGAGAAACCA CATTTTCATA ACTTTTGTTA CAGTATATTG TTATAATTGG 000480
000481 TCTATTTTTA TTATTATTGT TGTTCATATT TTACTTTAAT TTATAAATTA AACTTCATTA TAGGTATGTA CAGGAAAAAA 000560
000561 TATGGTATTA TATATGATTT GGTACTATCC TTGGTTTCAG GCATCCACTG AGGGTCTTGG AACATATCAC CTTGGATAGG 000640
000641 GGAGACTACT GACTTCCTTA CTGCTCTATG TGACAAATGA AGTTTGGTCT TATTTGCAGC CAGGAAAATT TTATTATCAA 000720
000721 GACTTTAATA TTAATACAGA AATAGGAACT TCCAGGGATA GACAAAAATG AAGAGAGCAT CTGTTCCAGC TTCTTTATTT 000800
000801 TAAAGATTTG AGGCTCAGAG AGGAGATATA CTTCTTCAAA ATCAACAGCC TATTAGTTCA CAACTGCGAT TACAATTTCG 000880
000881 TCTCCTGGCT CTGGGTTTAA TAATATTCCC CCACATCATA AAACCTTGGA ACTATCGAAA TGATAGCTTT GAGGGGAAAA 000960
000961 ATAGGCAAAG AAGTAATATG TTAAACTTTC CCTGGGATGC AGGCTTTAAT CAGGTTTCAA ATTCTTCCAA CATAATATAA 001040
001041 TTTAATGGTG AGAGCTCTTG ACATTAAGAG GTGAAATTTA TATTTAAAAG GCTAAGATCG TGACATATTA AAGCACTTCA 001120
001121 AAAATGTTGG CAACAAATAC CAAGAGTAAC TGATGGTTGT TATTATACAA GAACAAAGAA GTTCATCCTC TGGAATTAAA 001200
001201 GGTGTGTTAG TGTCATTGTT GCTCATGGGG AGGAGTAGGC ACCTGACTTT CTTTTTTTCC TTACGACAGC TTTATCCAAA 001280
001281 TAAAGCACGG TGTGTTTCAT CACCCATAAT GGAAAGTGCC TGTCACTCCT TGAACAACAT CATATGGTTG GTGGCCGGTG 001360
001361 GATAATGGAC CACTGAGTGT CAAGGTGACT GGCTTTCAAT GCACACAAAA CTAAAAATTA TAGACCTGTC ATTCCACAGG 001440
001441 CAGGCCACAA TTAGCTGTCT ATGCAACTTG AAATTTCCAT TTTGCCAGCT GAGTAATCAT TTGACTAGAG TTTTTCATTT 001520
001521 GGAAGCATTT CTAAGCCTTT TGTGTGCAAG TCTTTTAAAA TGTGGATCCT GAAGTAAATA AACAGTGCAC TTAATCAGAT 001600
001601 GTATTCTTTT TAGAAACACC CCTTCGGAAA CACACAGGCA AACCCCAACA TTGTTGTAAT AGTAACAACA ATAATGTGAC 001680
001681 AAAACAATAT AAGCCTTGGG TATTTTATTT AGGGATCTTA AAAGTTCACA GCGAAAGGTA AGAATCATTT CTTAATACCT 001760
001761 CAGAGTGCAG AATTTAGAAA AAGAAACTGA GATTTTAGCA GTCAGTAACT AGATAAGGTC ACCAAAGGAG AAGTAAACTC 001840
001841 AGAGCTAGGG GTCAAAACTT GGGAATTTCA GTGTCAGAAA CATTCACTGA TTCAAAACTA TCCATTTACC AGTTTTCTAT 001920
001921 TTACATTTGG TTTCCAACTC CATATCTGAG TTCTGTCATT TCTCTGATTC TTTGAGGGAT AGAGAAAATG ATACCAAGTG 002000
002001 GAGTCTGTTG GAAAATTGTG TTGTAATTTC CATTCAGTTG CTGTACGTGA AGTAAACTTC AGGATTCTAC AATCCCAGAT 002080
002081 CAGATTCTAG ACTGTCTAAT TGAACCTGAA TCTTCTTTTA CCCTCTTCCT GCCCTGTCCC TGGTCCACAT TACTCTCTCT 002160
002161 CCTTCTCCCT CGGATGATTT ATATCTACAC TTAAATTGCC GAGCCACAAG GATACAAGTG AAGTTGACAA TCAATATGAA 002240
002241 TTAAGGAAAA AATCAGAAGT CTGAGATCAG AAGTGTTTGA GTGAAATTCT CCCTACAAGT CTTGGCAACC TCATGATTTT 002320
002321 GTTTAATTTT CCAACATGTT TTGGATTATT GGAAAGAGTT ACATGGGATA AAAAGGATTT GCCTGGCAGA GTAAAAGAAC 002400
002401 TGAATTTGGA TTGTACTGAA GTAGGTCCTA ACTAGGCTGT TGATGGTGAA ATATTGACGA TTCTATTGTT TTGAATGAAT 002480
002481 GAGTGTCATA TTTTACTGGG AATTGATTTC TGAACTTCAG TCAAGGAGTG ACTGAATTTG CAATTAGAGT CACTCTGTTT 002560
002561 TGTAACTCAG ATTATGCAAG GATCATTCTG AAACAGCAAC CAAGATATAA GCCCTTGTTG CATGGCTTTT CTTTAATTTC 002640
002641 TAATTTTGTG TGTCTGTGTT CAGTTTTTAA AGGACCAAAA AGTTTTTTTT CCCCCATCTC TCTAGAAAAA AAAGGAACAT 002720
002721 ACCCTAGGAT TACAAGGGGC TTGATTATCT GTTTTATAAG AATCTTAACC CAGGAATTGG TTAATATTCT TTCTCCCATT 002800
002801 TAGAAAAATA GTAGGCTTTG TCGTTGATTC CTAATGATTA GCACAAAAAG GGAAAGGCTT TTTAAAACCA AGATAAAATC 002880
002881 ACTTTAATTC CAAAAGTGTC CATTTAAGAA ATATAAACTG TGAAGATAAG CAATGGCTAT TTTCTCTAAA GGAAAGTATT 002960
002961 TTCAAATGAA CAGAACAGGC AAATGTAGAC TTAATTAGGT GGAGTCAGAT GGGTATTAAT TATTCACCTT TCCAGGGTGA 003040
003041 GAATAATAGC ATTGTTGCTA AAGAAATGAA ATAAGGCATG ACACTTCTTT CTTCTTCATT CTGTGAAAGC TGCTCTGATC 003120
003121 TGAACAGGTT AAAGATGGGA TAACAGGAGG ACAGACTGAA AATTTGCTCT TCCCTTCACA ATTGAGGGTA GATAGTCTTT 003200
003201 CGAGAGTGTA GTATCCTCCA TTGAAATAAA ATGTTATTGA CTACCTGCTT GGAGACATAA AAACCTTCTC ATGTTTGGAA 003280
003281 TGTACATGTA CTTCTCTGTT TTGCTCTCTT GAACATTTTC AAAATAGCTA AATAAAATTT GTCCTCATTC TTAGAGTTCT 003360
003361 GTATATTCTA GACTTGAAAA TAGTGGCCAA CAGTGAGTAG TAATTCACAC TGATGATAAT CACACCAGAC TAGGTTTGTT 003440
003441 TAATTTTGTT ATAGCCTCTA AAAAGCATTT GTTAAGCATC TGCTCTGTTA CACAGGTAAG ATCTCATGAT GGATGTGGAG 003520
003521 TCTACAAATG AAAAATACTT AAACGCACTG CAGTAAAAGA TCAACACTTA CTCTAATATA ATTTGTTAGT ACCGAGTGTC 003600
003601 AAAAAGTGGG GTTTGAAAAA ACCTAAGGGT AAGATTTAGC AGGTGTGGGG TCTAGTCCTG ACACTGATGG TGACTACTTG 003680
003681 TTGCCTACCT CAATTCTGGT CATAAGAGCT ATGAGTGTGA ATGTGTATGT TAAGTAGTGT GAGGTTGTGT GACTGGAAGG 003760
003761 GGCTGGAGGA AATAGAGGCA GAGAAACTCA GCAACCCTGA GTTGCAGAGA AGCTTTTTTA GTGTCCCTGA GAAGTGAAAT 003840
003841 GACTCTGTTA TTATGTCTGC ATGCTAATTA TACCTCTACT CTACATACTT TTAACTTTAG GTAACCTCAT GTTAACTGCC 003920
003921 TTTTTAAGCT GAGGAAACCA ATACCCATGG AGATAAAATG ACTTGACCCA AATCGGACAG CTTGTCAATA GCAAAGCTGG 004000
004001 AACCAGACTG TAAAGCTTCT GCTTTCTTGT GTAAGATACA TTTTTCCCCT AGATGACTTC TTAAACCAAG GGGCTCTGAA 004080
004081 AATAAACAAT CTTTTCAAAG TAGCACTGTA TCCCTGTAGG TTGTTGCAAA TAGTTCTTCA AAACTTGAAA TAATTATATC 004160
004161 ATCTTAAAAA GTCCCTTATA AATTCCAATT CAGTATAAAA ATATGATTTA GGTATATGTT AATTAA
000081 TCGTGGAGTC TATATAAGAT CTTCAAAGAA AGAGATATCC TTTCGAGGCA ACACAAGAAG CCAACTACAA ATGAGAATAT 000160
000161 TATTCTCTTG GTGCAGGGAT TGTTGCATGT GGACCCCATC AGCCTTGAAA AGTCCATGCA ATGGAGTGAA ACTTGACAAA 000240
000241 GCAGTTGCAG TCGTTCACCA GTGAAGCAAA GTCTTCTTCC TAGTCACGCA GGAATTTTTT TGGGGGAGAT AACTTGATGC 000320
000321 CTGGAGCTGC TGCTGCATCT TATGTAAATG ACAACTAAGG ATAAAAACCA CACACATTAC CCAAGGTGCA GTAAAAGAAG 000400
000401 ATATTTTGGG AGGAAGAGAG AAAGCAAGAG AGAGAAACCA CATTTTCATA ACTTTTGTTA CAGTATATTG TTATAATTGG 000480
000481 TCTATTTTTA TTATTATTGT TGTTCATATT TTACTTTAAT TTATAAATTA AACTTCATTA TAGGTATGTA CAGGAAAAAA 000560
000561 TATGGTATTA TATATGATTT GGTACTATCC TTGGTTTCAG GCATCCACTG AGGGTCTTGG AACATATCAC CTTGGATAGG 000640
000641 GGAGACTACT GACTTCCTTA CTGCTCTATG TGACAAATGA AGTTTGGTCT TATTTGCAGC CAGGAAAATT TTATTATCAA 000720
000721 GACTTTAATA TTAATACAGA AATAGGAACT TCCAGGGATA GACAAAAATG AAGAGAGCAT CTGTTCCAGC TTCTTTATTT 000800
000801 TAAAGATTTG AGGCTCAGAG AGGAGATATA CTTCTTCAAA ATCAACAGCC TATTAGTTCA CAACTGCGAT TACAATTTCG 000880
000881 TCTCCTGGCT CTGGGTTTAA TAATATTCCC CCACATCATA AAACCTTGGA ACTATCGAAA TGATAGCTTT GAGGGGAAAA 000960
000961 ATAGGCAAAG AAGTAATATG TTAAACTTTC CCTGGGATGC AGGCTTTAAT CAGGTTTCAA ATTCTTCCAA CATAATATAA 001040
001041 TTTAATGGTG AGAGCTCTTG ACATTAAGAG GTGAAATTTA TATTTAAAAG GCTAAGATCG TGACATATTA AAGCACTTCA 001120
001121 AAAATGTTGG CAACAAATAC CAAGAGTAAC TGATGGTTGT TATTATACAA GAACAAAGAA GTTCATCCTC TGGAATTAAA 001200
001201 GGTGTGTTAG TGTCATTGTT GCTCATGGGG AGGAGTAGGC ACCTGACTTT CTTTTTTTCC TTACGACAGC TTTATCCAAA 001280
001281 TAAAGCACGG TGTGTTTCAT CACCCATAAT GGAAAGTGCC TGTCACTCCT TGAACAACAT CATATGGTTG GTGGCCGGTG 001360
001361 GATAATGGAC CACTGAGTGT CAAGGTGACT GGCTTTCAAT GCACACAAAA CTAAAAATTA TAGACCTGTC ATTCCACAGG 001440
001441 CAGGCCACAA TTAGCTGTCT ATGCAACTTG AAATTTCCAT TTTGCCAGCT GAGTAATCAT TTGACTAGAG TTTTTCATTT 001520
001521 GGAAGCATTT CTAAGCCTTT TGTGTGCAAG TCTTTTAAAA TGTGGATCCT GAAGTAAATA AACAGTGCAC TTAATCAGAT 001600
001601 GTATTCTTTT TAGAAACACC CCTTCGGAAA CACACAGGCA AACCCCAACA TTGTTGTAAT AGTAACAACA ATAATGTGAC 001680
001681 AAAACAATAT AAGCCTTGGG TATTTTATTT AGGGATCTTA AAAGTTCACA GCGAAAGGTA AGAATCATTT CTTAATACCT 001760
001761 CAGAGTGCAG AATTTAGAAA AAGAAACTGA GATTTTAGCA GTCAGTAACT AGATAAGGTC ACCAAAGGAG AAGTAAACTC 001840
001841 AGAGCTAGGG GTCAAAACTT GGGAATTTCA GTGTCAGAAA CATTCACTGA TTCAAAACTA TCCATTTACC AGTTTTCTAT 001920
001921 TTACATTTGG TTTCCAACTC CATATCTGAG TTCTGTCATT TCTCTGATTC TTTGAGGGAT AGAGAAAATG ATACCAAGTG 002000
002001 GAGTCTGTTG GAAAATTGTG TTGTAATTTC CATTCAGTTG CTGTACGTGA AGTAAACTTC AGGATTCTAC AATCCCAGAT 002080
002081 CAGATTCTAG ACTGTCTAAT TGAACCTGAA TCTTCTTTTA CCCTCTTCCT GCCCTGTCCC TGGTCCACAT TACTCTCTCT 002160
002161 CCTTCTCCCT CGGATGATTT ATATCTACAC TTAAATTGCC GAGCCACAAG GATACAAGTG AAGTTGACAA TCAATATGAA 002240
002241 TTAAGGAAAA AATCAGAAGT CTGAGATCAG AAGTGTTTGA GTGAAATTCT CCCTACAAGT CTTGGCAACC TCATGATTTT 002320
002321 GTTTAATTTT CCAACATGTT TTGGATTATT GGAAAGAGTT ACATGGGATA AAAAGGATTT GCCTGGCAGA GTAAAAGAAC 002400
002401 TGAATTTGGA TTGTACTGAA GTAGGTCCTA ACTAGGCTGT TGATGGTGAA ATATTGACGA TTCTATTGTT TTGAATGAAT 002480
002481 GAGTGTCATA TTTTACTGGG AATTGATTTC TGAACTTCAG TCAAGGAGTG ACTGAATTTG CAATTAGAGT CACTCTGTTT 002560
002561 TGTAACTCAG ATTATGCAAG GATCATTCTG AAACAGCAAC CAAGATATAA GCCCTTGTTG CATGGCTTTT CTTTAATTTC 002640
002641 TAATTTTGTG TGTCTGTGTT CAGTTTTTAA AGGACCAAAA AGTTTTTTTT CCCCCATCTC TCTAGAAAAA AAAGGAACAT 002720
002721 ACCCTAGGAT TACAAGGGGC TTGATTATCT GTTTTATAAG AATCTTAACC CAGGAATTGG TTAATATTCT TTCTCCCATT 002800
002801 TAGAAAAATA GTAGGCTTTG TCGTTGATTC CTAATGATTA GCACAAAAAG GGAAAGGCTT TTTAAAACCA AGATAAAATC 002880
002881 ACTTTAATTC CAAAAGTGTC CATTTAAGAA ATATAAACTG TGAAGATAAG CAATGGCTAT TTTCTCTAAA GGAAAGTATT 002960
002961 TTCAAATGAA CAGAACAGGC AAATGTAGAC TTAATTAGGT GGAGTCAGAT GGGTATTAAT TATTCACCTT TCCAGGGTGA 003040
003041 GAATAATAGC ATTGTTGCTA AAGAAATGAA ATAAGGCATG ACACTTCTTT CTTCTTCATT CTGTGAAAGC TGCTCTGATC 003120
003121 TGAACAGGTT AAAGATGGGA TAACAGGAGG ACAGACTGAA AATTTGCTCT TCCCTTCACA ATTGAGGGTA GATAGTCTTT 003200
003201 CGAGAGTGTA GTATCCTCCA TTGAAATAAA ATGTTATTGA CTACCTGCTT GGAGACATAA AAACCTTCTC ATGTTTGGAA 003280
003281 TGTACATGTA CTTCTCTGTT TTGCTCTCTT GAACATTTTC AAAATAGCTA AATAAAATTT GTCCTCATTC TTAGAGTTCT 003360
003361 GTATATTCTA GACTTGAAAA TAGTGGCCAA CAGTGAGTAG TAATTCACAC TGATGATAAT CACACCAGAC TAGGTTTGTT 003440
003441 TAATTTTGTT ATAGCCTCTA AAAAGCATTT GTTAAGCATC TGCTCTGTTA CACAGGTAAG ATCTCATGAT GGATGTGGAG 003520
003521 TCTACAAATG AAAAATACTT AAACGCACTG CAGTAAAAGA TCAACACTTA CTCTAATATA ATTTGTTAGT ACCGAGTGTC 003600
003601 AAAAAGTGGG GTTTGAAAAA ACCTAAGGGT AAGATTTAGC AGGTGTGGGG TCTAGTCCTG ACACTGATGG TGACTACTTG 003680
003681 TTGCCTACCT CAATTCTGGT CATAAGAGCT ATGAGTGTGA ATGTGTATGT TAAGTAGTGT GAGGTTGTGT GACTGGAAGG 003760
003761 GGCTGGAGGA AATAGAGGCA GAGAAACTCA GCAACCCTGA GTTGCAGAGA AGCTTTTTTA GTGTCCCTGA GAAGTGAAAT 003840
003841 GACTCTGTTA TTATGTCTGC ATGCTAATTA TACCTCTACT CTACATACTT TTAACTTTAG GTAACCTCAT GTTAACTGCC 003920
003921 TTTTTAAGCT GAGGAAACCA ATACCCATGG AGATAAAATG ACTTGACCCA AATCGGACAG CTTGTCAATA GCAAAGCTGG 004000
004001 AACCAGACTG TAAAGCTTCT GCTTTCTTGT GTAAGATACA TTTTTCCCCT AGATGACTTC TTAAACCAAG GGGCTCTGAA 004080
004081 AATAAACAAT CTTTTCAAAG TAGCACTGTA TCCCTGTAGG TTGTTGCAAA TAGTTCTTCA AAACTTGAAA TAATTATATC 004160
004161 ATCTTAAAAA GTCCCTTATA AATTCCAATT CAGTATAAAA ATATGATTTA GGTATATGTT AATTAA
