MYOPARR
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MYOPARR, a long noncoding RNA, is essential for the expression of human myogenin gene, which is one of the key myogenic transcription factors.
Contents
Annotated Information
Name
Approved symbol: MYOPARR
Approved name: MYOPARR: myogenin promoter-associated myogenic regulatory antisense long non-coding RNA.
HGNC ID: HGNC: 54178
RefSeq ID: NR_160550
Characteristics
MYOPARR
Function
- MYOPARR is essential both for the specification of myoblasts by activating neighboring myogenin expression and for myoblast cell cycle withdrawal by activating myogenic microRNA expression. Mechanistically, MYOPARR interacts with Ddx17, a transcriptional coactivator of MyoD, and regulates the association between Ddx17 and the histone acetyltransferase PCAF[1].
- MYOPARR also promotes skeletal muscle atrophy caused by denervation, and knockdown of MYOPARR rescues muscle wasting in mice[1].
Regulation
Diseases
Expression
MYOPARR is coexpressed with myogenin, the expression of which is highly restricted to myogenic tissues in embryonic, fetal, and adult skeletal muscles [1].
Evolution
Labs working on this lncRNA
- Division for Therapies against Intractable Diseases, Institute for Comprehensive Medical Science (ICMS), Fujita Health University, Toyoake, Japan.
- Department of Medical Technology, School of Health Sciences, Gifu University of Medical Science, Seki, Japan.