NNT-AS1

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Annotated Information

Name

NNT-AS1:NNT antisense RNA 1

Characteristics

NNT-AS1 is a newly detected lncRNA, which located in 5p12 with 3 exons and transcribed in the opposite direction of nicotinamide nucleotide transhydrogenase (NNT). However, there is no overlap between NNT-AS1 and NNT.[1]

Function

Function analysis of NNT-AS1 in vitro[1].

Silencing NNT-AS1 can inhibit cell proliferation, colony formation, cell cycle and suppress tumor growth and metastasis in vivo. In addition, silencing NNT-AS1 can attenuate EMT and MAPK/Erk signaling pathway in CRC(Colorectal cancer cell) cells. The knockdown of NNT-AS1 can inhibit CRC migration and invasion in vitro.[1]

Expression

The expression of NNT-AS1 and associated with survival of CRC patients[1].

The expression of NNT-AS1 is significantly higher in the cancerous tissues than that in the adjacent normal tissues.​[1]

Diseases

Colorectal cancer(CRC)[1]

Sequence

>NR_073113.1 Homo sapiens NNT antisense RNA 1 (NNT-AS1), long non-coding RNA

000001 AGACCCGGGC TTGGGCCCCG CGGCGCTGCG CCTCCAACCC GGAAGAACAG CCCCAACTCC GCGGCGGCGG GCGGCCACGT 000080
000081 GACTGCAGCT CCGCTCCCAC CTCGGCCCGC GCCCCTTCCC CGCCCCAGCT TTCTTCCCGC CAGGCCCCCT CCACCCGATC 000160
000161 GCCGCGCGCT CTCCGAACCA AAAGGCGACC TCACGAAATG CCCCTTTGAG CTCAAAGGCT AGTTACCCCC AGGGGCCCTT 000240
000241 CCACTCTCGG GGACAGGCGA AACCTCTTTG TCTCTGCCTC GGCCTGCGGC CCCCAGCCCA GCCTCCGCGC TTTCCCTCCG 000320
000321 CCAGTCCTTG TCAATCAAAC CTGGTGCCAA ACGCGGCAGC TGAAGTTTTC AGGGACACAT TTGCTTCTCC CCTTGAAGAA 000400
000401 CCAGTTACAA AGCGTGATGT CCTCTCTGGG GTCCCATCAG AACAAAGAAA CAGGTCTAAA GACCCTCATT CCAGAGAGCA 000480
000481 TCCTGCCCCA TATCCAGAAT GAAATCCATG CTCAGAGATG CCAAGAAGAA TCTAGACAGA CAGGCCTTTC TAGGCTGTAC 000560
000561 AAGAAGCATG ATGCCAGCAT CTGCTTCTGG TGACAACCTC AAGAAGTTTA CAATTGGCCG CGTGCGGTGG CTCATGCCTG 000640
000641 TAATGCCAGC ACTTCGGGAG GCGGAGACAG ATGGATCATT TGAGGTCAGG AGTTCGAGAC CAGGCTGGCC AACATGGTGA 000720
000721 AACCCCATCT CTACTAAAAA TACAAAAATT AGCTGGGCAT GGTGGCATGT GTCTGGAATC CCTGCTACTC AGGAGGCTGA 000800
000801 GGCAAGAGGA TCACTTGGAA CTTGGGAGGC AGAGGTTGCT GTGAGCTGAG ATCACACCAC TGTACTCCAG CCTGGGCAAC 000880
000881 AGAGTGATAC TCTATCTCAA AAAAAAAAGA AAGAAAGAAA GAAAAGAAAA AGAAGCTTAC AATCATGGTG GAAGGCGAAG 000960
000961 AGGAGGAGCA GGCATATCAC ATGGCCAAAA AGGGAGCAAG AGAAAGGTGA GAAAGACACT AGACTCTTTT TAAAACCAGC 001040
001041 TCTCACATGA GCTAATGGAA TAAGAACTCA CTCATTACCA CAAGGACAGA ACCCAGCCAT TCATGAGGGA CCTGCCACCA 001120
001121 TGACCCAAAA ACCTCCTACT TGACCCAACC TCCAACACTG GGGATAACAT TTCAACATGA GATTTGAAGA GGACAAATAC 001200
001201 TCAAACTATA TCACTTGTTG TCCATTTTTA ATCTTTCTCT AACATACCCT AACTTCTTCT TGAAAATGCT TAATTTTCTC 001280
001281 TGTTTTGAGA TGTAAATTTG CTATCCTGTT TTTCTTAAAA CTTGGTAAGA TCTTCAGCCA TGAAGGACAG ACAAACTGTA 001360
001361 ACCTTTCCAT TTACAAAGCT GCATTTGAAT TCAACTGTCC TTTTAAACTA AGGAGTTTTA CTGGTCTCGT GGCTAAAATT 001440
001441 TTAAAGATGT AGGCCAGGTG CAGTGGCTCA TGCCTGTAAT CCTATCACTT TTGGAGACCA AGGCGGGGAT GGATCACCTG 001520
001521 AGGTCAGGAG TTCAAGACCA GCCTGGCCAA CATGATGAAA CTCCATCTCT ACTAAAAATA CAAAAATTAG TCAGGCATGG 001600
001601 TGGCACACAC CTGTAATCCC AGCTACTCGG GAGGCTGAGG CAAGAGAATG GCTTGAACCC GGGCGACGGA AGTTGCAGTG 001680
001681 AGGCGAGATT GCACCATTGC ACTCCAGCCT GGGCAATAAG AGTGAAACTC TGTCTCAAAA AAAGAAAAAA TGATATAAAG 001760
001761 TATTTATTTG TGTTTATATT TTATGGATAC GTGTCTATGT TTATAGATTG CCTGTATGGT ACCAACTTGA CATAAATAAA 001840
001841 TTAGTACTCA TAAATTAAGT AAATAAGCCC AAACGCTTTT CAAGTTCACA GGGCATTAGT AATCTGTGGT AAATGAAGAT 001920
001921 AGTTTAAAAT TTGGGGTAAA ATAAAATAGA AACATTTTCT GAATTTAATT TAGATATTTT TCTGGGTCTA TTTGTTAGAC 002000
002001 AGGTTTACAC TATCTCTGCT ATTTTTTTAA GGACCTAAAA CTGAATGGAC ATAGAAAATT GAGGAAAGAA ATAAAACCGT 002080
002081 AACAATTATA AGAGGTTATA AAAGGTTCAT GGAACCTTTT TATGTTTTTT CTTGTGCAGT CAAAACCAAT TGCAGGCTGG 002160
002161 ATGCAGTAGC TCACACTTGT AATCCCAGCA CTTTGGGAGG CTGAGATGGG CAGATCACTT GAGCTCAGGA GTTTGAGACC 002240
002241 ATCCTGGGCA ACATAGTGAA ACTCTCTCAC TACCAAAGTA CAAAAGGAAT TAGCTGGGCA TGATGGTACA CACTTGTAGT 002320
002321 CCCAGCTACT TGGGGGACTG AGATGGGAAA ATTGCTTGAG CCCGGGAGTC AAAGGTTGCA GTAAGCCAAG ATTGCACCAC 002400
002401 TACACTCCAG CCTGGGTGAC AAAGTGAGAC CCTGTCTCAA AAAAAAACAA AAAAAGGAAA AGAAAACAAT TGCAATTGGA 002480
002481 TTGATCTGTT TATAAGGCTT TATTAAAATT AGCTTTAGCA TTTATAATAC ACTGGCACAA AGTTAGAATT TGGATTTCTC 002560
002561 TTTTGAACAA GATTTTTGTA TACATTAATA AGAAATAGTA AAAGATTTTT GTTTACCTTT TGAGTAAACT GCAAAAAATA 002640
002641 TTAGTAATAA GAGGAGAGAA TTTCCCTAAT GCTGTTTTTA TTATGTCTTT TGATTGTTTG GAAAACTGAA TCTCCCCTCT 002720
002721 GTCAAAGAGT AAAATTTTTG CTTTTTGAAA TTTTTGAATT ATCAGTTTGG CTAAATGAAT AACTATTATC TTACAGTGAC 002800
002801 CTGTAATCTT ATTTTGATCA AGTGTTTTAA ACCTTTGATA TTTGACAAAC TTCCCAAAAT CAAATGTAAA ATTCTAACTT 002880
002881 AAATGTTTTC GACCTCAAGC TAACTTTTGG GCATTAAAGC CCTTGGAAGT CCAAATAGGG CCCCTGGAAG TCCAAAAGAA 002960
002961 ACATATTAGG CTAATTTGGT ATATTAAAAT CATACAGGAA GCTGATCAAA TAAAAAATGT TGTTTAATTT TCTTTGAGTT 003040
003041 GTATTTGTAT AAATCTGTTA TTAATATGCA TCCCAAAATT GTATCATATT GCTAAAATGT TGATAGATCT TGTTATATGT 003120
003121 TATTGGTAAT AATTGTTATC CTGTTAAATT ATTGTATACC ACAGAAATAA TGAAATTTCT TTGTCAATTG CATCAGTAAT 003200
003201 CATGGCTCTT CTAAGTCTTT TGTCATTCAC AGATGATTAT TGTTTTACTT GGATTCTTTT CAAAAGTGGT TTGTAATTGG 003280
003281 CTACAGCCTA AAATCTGCTT GTTC

Labs working on this lncRNA

  • Department of Oncology, Affiliated Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Wang Q, Yang L, Hu X, Jiang Y, Hu Y, Liu Z, Liu J, Wen T, Ma Y, An G, Feng G. Upregulated NNT-AS1, a long noncoding RNA, contributes to proliferation and migration of colorectal cancer cells in vitro and in vivo. Oncotarget. 2017 Jan 10;8(2):3441-3453.
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