Difference between revisions of "NONHSAT022116"
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==Annotated Information==
===Transcriptomic Nomeclature===
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[[Category:Intergenic]] | [[Category:Intergenic]] | ||
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+ | {{lncrnadb| | ||
+ | tID = NONHSAT022116| | ||
+ | ltID = TncRNA| | ||
+ | ann = <tab class=wikitable sep=tab head=top> | ||
+ | Section Description | ||
+ | ID TncRNA | ||
+ | Characteristics ~480 nuc [http://www.ncbi.nlm.nih.gov/pubmed/9858482 (Peyman (1999))], independent transcript from the 3' end of the Neat1 short isoform/MEN epsilon.<br /> Contains a number of sequence motifs that match binding sites for proteins involved in cytokine signalling which up-regulate MHC genes [http://www.ncbi.nlm.nih.gov/pubmed/9858482 (Peyman (1999))]. | ||
+ | Expression Expressed exclusively in the placenta and pancreas while full length Neat1 is expressed ubiquitously. Placenta was the only tissue where TncRNA predominated [http://www.ncbi.nlm.nih.gov/pubmed/9858482 (Peyman (1999))]. | ||
+ | Function Suppressed induction of MHC class II antigens by interferon gamma and partially blocked constitutive and interferon gamma induced expression of MHC class I antigens and ICAM-I ([http://www.ncbi.nlm.nih.gov/pubmed/9858482 Peyman (1999)], [http://www.ncbi.nlm.nih.gov/pubmed/12565840 Geirsson (2003)])<br />Suppressed major histocompatibility (MHC) class II expression in-vitro through inhibition of class II transactivator (CIITA) promoters ([http://www.ncbi.nlm.nih.gov/pubmed/12565840 Geirsson (2003)], [http://www.ncbi.nlm.nih.gov/pubmed/12883198 Geirsson (2003)], [http://www.ncbi.nlm.nih.gov/pubmed/15454174 Geirsson (2004)]). Also bound STAT1 and reduced its nuclear translocation [http://www.ncbi.nlm.nih.gov/pubmed/9858482 (Peyman (1999))], contributing to suppression of MHCII and I in human trophoblast cells and hence preventing a deleterious maternal immune response to placental invasion of the uterine wall.<br /> Note: While STAT1 binds the CIITA promoter, it's binding did not appear to be affected by TncRNA, which acted on an area with no known transcription factor binding sites [http://www.ncbi.nlm.nih.gov/pubmed/12883198 (Geirsson (2003))], so the mechanism is unclear. | ||
+ | Misc This transcript comes from the very 3' end of the Neat1 short isoform. It is therefore part of Neat1 but as described above appears to be expressed independently with a function different to that of the full length transcript. | ||
+ | Name TncRNA: trophoblast noncoding RNA.<br /> TSU: trophoblast STAT utron (untranslated region of an mRNA). | ||
+ | </tab>| | ||
+ | }} |
Revision as of 12:18, 6 October 2014
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Contents
Annotated Information
Transcriptomic Nomeclature
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Function
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Regulation
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Expression
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Allelic Information and Variation
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Evolution
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You can also add sub-section(s) at will.
Labs working on this lncRNA
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References
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Basic Information
Transcript ID |
NONHSAT022116 |
Source |
NONCODE4.0 |
Same with |
, |
Classification |
intergenic |
Length |
481 nt |
Genomic location |
chr11+:65193526..65194002 |
Exon number |
1 |
Exons |
65193526..65194002 |
Genome context |
|
Sequence |
000001 AAGCGGCGAG GTGCCTTTAC TACATGTGTG ATCTGAAAAC CCTGCTTGGT TCTGAGCTGC GTCTATTGAA TTGGTAAAGT 000080
000081 AATACCAATG GCTTTTTATC ATTTCCTTCT TCCCTTTAAG TTTCACTTGA AATTTTAAAA ATCATGGTTA TTTTTATCGT 000160 000161 TGGGATCTTT CTGTCTTCTG GGTTCCATTT TTTAAATGTT TAAAAATATG TTGACATGGT AGTTCAGTTC TTAACCAATG 000240 000241 ACTTGGGGAT GATGCAAACA ATTACTGTCG TTGGGATTTA GAGTGTATTA GTCACGCATG TATGGGGAAG TAGTCTCGGG 000320 000321 TATGCTGTTG TGAAATTGAA ACTGTAAAAG TAGATGGTTG AAAGTACTGG TATGTTGCTC TGTATGGTAA GAACTAATTC 000400 000401 TGTTACGTCA TGTACATAAT TACTAATCAC TTTTCTTCCC CTTTACAGCA CAAATAAAGT TTGAGTTCTA AACTCATTAA 000480 000481 A |
Annotation (From lncRNAdb)
Section | Description |
---|---|
ID | TncRNA |
Characteristics | ~480 nuc (Peyman (1999)), independent transcript from the 3' end of the Neat1 short isoform/MEN epsilon. Contains a number of sequence motifs that match binding sites for proteins involved in cytokine signalling which up-regulate MHC genes (Peyman (1999)). |
Expression | Expressed exclusively in the placenta and pancreas while full length Neat1 is expressed ubiquitously. Placenta was the only tissue where TncRNA predominated (Peyman (1999)). |
Function | Suppressed induction of MHC class II antigens by interferon gamma and partially blocked constitutive and interferon gamma induced expression of MHC class I antigens and ICAM-I (Peyman (1999), Geirsson (2003)) Suppressed major histocompatibility (MHC) class II expression in-vitro through inhibition of class II transactivator (CIITA) promoters (Geirsson (2003), Geirsson (2003), Geirsson (2004)). Also bound STAT1 and reduced its nuclear translocation (Peyman (1999)), contributing to suppression of MHCII and I in human trophoblast cells and hence preventing a deleterious maternal immune response to placental invasion of the uterine wall. Note: While STAT1 binds the CIITA promoter, it's binding did not appear to be affected by TncRNA, which acted on an area with no known transcription factor binding sites (Geirsson (2003)), so the mechanism is unclear. |
Misc | This transcript comes from the very 3' end of the Neat1 short isoform. It is therefore part of Neat1 but as described above appears to be expressed independently with a function different to that of the full length transcript. |
Name | TncRNA: trophoblast noncoding RNA. TSU: trophoblast STAT utron (untranslated region of an mRNA). |