Difference between revisions of "NONHSAT028496"

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(Regulation)
(Function)
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[[File:DA125942 transcription and dependent regulation of SOX9, DA125942, and PTHLH..jpg|right|thumb|400px|'''DA125942 transcription and dependent regulation of SOX9, DA125942, and PTHLH.''' <ref name="ref1" />.]]
 
[[File:DA125942 transcription and dependent regulation of SOX9, DA125942, and PTHLH..jpg|right|thumb|400px|'''DA125942 transcription and dependent regulation of SOX9, DA125942, and PTHLH.''' <ref name="ref1" />.]]
  
''CISTR'' silencing led to PTHLH or SOX9 repressions in humans and rodents, whereas their altered expression coincided with lncRNA dysregulation.
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''CISTR'' silencing led to PTHLH or SOX9 repressions in humans and rodents, whereas their altered expression coincided with lncRNA dysregulation.<ref name="ref1" />
  
 
===Regulation===
 
===Regulation===

Revision as of 16:54, 2 April 2015

CISTR, a chondrogenic regulator, interacts in cis with PTHLH expression and simultaneously in trans with sex-determing region Y-box9(SOX9).

Annotated Information

Transcriptomic Nomeclature

CISTR:chondrogenesis-associated transcript (HGNC nomenclature)

Function

DA125942 transcription and dependent regulation of SOX9, DA125942, and PTHLH. [1].

CISTR silencing led to PTHLH or SOX9 repressions in humans and rodents, whereas their altered expression coincided with lncRNA dysregulation.[1]

Regulation

Knocking down PTHLH and SOX9 significantly increased CISTR expression by 4- and 6.8-fold,respectively.[1]

Expression

In the BDE patients, the CISTR occupancy at the PTHLH locus was reduced.

siRNA sense antisense
siRNA 1 GCACAUGACCACAUGGAAATT UUUCCAUGUGGUCAUGUGCGA [1]
siRNA 2 GUUUCUCUCAGCAAAUUCATT UGAAUUUGCUGAGAGAAACTG [1]
siRNA 3 CAAGGACACUGAAAAAGCUTT AGCUUUUUCAGUGUCCUUGAG [1]

Allelic Information and Variation

Please input allelic information and variation information here.

Evolution

Please input evolution information here.

You can also add sub-section(s) at will.

Labs working on this lncRNA

Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Cite error: Invalid <ref> tag; no text was provided for refs named ref1

Basic Information

Transcript ID

NONHSAT028496

Source

NONCODE4.0

Same with

,

Classification

intergenic

Length

772 nt

Genomic location

chr12-:54144081..54145660

Exon number

2

Exons

54144081..54144749,54145558..54145660

Genome context

Sequence
000001 gggaggaaaa gaggcgggag agagaCCCTA AAAAGCAAGC TAGACTCTCC AGCCGGCCGC TCTGGTGTGG GGAGGGAGCG 000080
000081 TCATCTCAAG GACACTGAAA AAGCTGTTTG CCGTTTTGCT GTTTGCCTCC TTGTCACGAC CTCAGCGACG GCAGATGGAG 000160
000161 CCAGTGGAGG GAGAGAGACA GACGGCAATG CTTGGGTAGC CAGGGCTCCC TGCCGGCCCC ACTCCTCCTG CAGACACGAG 000240
000241 CACGCACACA CACACGCGCG CAAAACACAC ACGCTGCCCT TCGCCACACG TAGCCAAGTA AAATACACAA AAAGCAACTG 000320
000321 AGATACCATT CGCACATGAC CACATGGAAA CACACAAATG AACAAACGCA TTCAGGCATA GCCACATGCC AGTCACACAG 000400
000401 ATGGATAGAC AAGAGCCTGG GGTACAAAGC CACATGGCAC AAAGCCACCT GGATGTATAT GCCCCTacac acgcacacag 000480
000481 aaaaaaacat gcaaacttaa gtacacacct atccagacaa gtgtgagtgc acacacacac acactcacac acTCTACCTG 000560
000561 ACACGTTAGT GCATCCCCAT TGGGCCCCAG TTTCTCTCAG CAAATTCAGA TCACCCAGCC TGACTTCAAA ACCTGCCCCC 000640
000641 TTCCATTCCC CTTCATGCTG GTTCCTGAAT CCAGCTCGTT GCTCCAGGCT AGCAAAGCTG TCCACAGCCT CATTTGTGGT 000720
000721 TTGCTCACCT GCCTCAGCAC CATCAGCCAG AGGTACTCCT GCTCTTCTCC TA
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