Difference between revisions of "NONHSAT040039"

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[[Category:Intergenic]]
 
[[Category:Intergenic]]
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{{lncrnadb|
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tID = NONHSAT040039|
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ltID = Dio3os|
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ann = <tab class=wikitable sep=tab head=top>
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Section Description
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ID Dio3os
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Characteristics Antisense and head to head with Dio3 from the Dlk1-Dio3 imprtinted locus [http://www.ncbi.nlm.nih.gov/pubmed/14962667 (Hernandez (2004))]. A large number of isoforms are transcribed through alternative splicing and start sites some of which overlap Dio3 [http://www.ncbi.nlm.nih.gov/pubmed/14962667 (Hernandez (2004))]. Also overlaps a provisional microRNA miR1247.
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Expression Various DIO3OS isoforms are expressed in a wide range of human tissues including adult testis, adrenal cortex, heart, bladder, uterus, placenta and fetal lung [http://www.ncbi.nlm.nih.gov/pubmed/14962667 (Hernandez (2004))]. Expressed in embryonic and extra-embryonic tissue in mouse. Weakly expressed in several neonatal and adult tissues: brain and liver (adult only), intestine and tougue (neonate only),  kidney and lung (expressed in both) [http://www.ncbi.nlm.nih.gov/pubmed/16309881 (Tierling (2006))]. Analysis in different cell culture lines showed co-expression of DIO3OS transcripts and DIO3 [http://www.ncbi.nlm.nih.gov/pubmed/16935842 (Kester (2006))]. Conversely differentiation of mature brown adipose tissue (BAT) adipocytes from precursor cells showed that Dio3 was only expressed in the proliferating precursors while a specific Dio3os isoform was expressed only in differentiated adipocytes [http://www.ncbi.nlm.nih.gov/pubmed/17510246 (Hernandez (2007))]. Not imprinted in mouse [http://www.ncbi.nlm.nih.gov/pubmed/16309881 (Tierling (2006))].
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Conservation Aside from the short exon 1, there is poor sequence conservation and no conserved ORFs between mouse and human Dio3os [http://www.ncbi.nlm.nih.gov/pubmed/14962667 (Hernandez (2004))].
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</tab>|
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Revision as of 11:47, 6 October 2014

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Annotated Information

Transcriptomic Nomeclature

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Function

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Regulation

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Expression

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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References

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Basic Information

Transcript ID

NONHSAT040039

Source

NONCODE4.0

Same with

,

Classification

intergenic

Length

1746 nt

Genomic location

chr14-:102023641..102026759

Exon number

2

Exons

102023641..102025171,102026589..102026759

Genome context

Sequence
000001 CCGCTTGCCT CGCCCAGCGC AGCCCCGGCC GCTGGGCGCA CCCGTCCCGT TCGTCCCCGG ACGTTGCTCT CTACCCCGGG 000080
000081 AACGTCGAGA CTTGAGCGCC CGAACTGAGC CACCTTCGCG GACCCCGAGA GCGGCGGCGC GACTCACCGC GGAGGCGCCC 000160
000161 GGACGCGTCA AGCCCAGCCC AATAAGAAGC ACCTGATCCA CACTCTTTCT AGCCCCAGGG ATGCTCAGGA AAGCAGCCTT 000240
000241 TCTTTAGGGC TGTCATCTGT TCTGGGGATC TGTTGCTGTT TCTTGGGCCC ACAGAATACA CTCCACACCT CGGGACTCCA 000320
000321 TAATATTGGA CAAGGCTGGA AGGCCCATTT GGCTCCTGCA GCCTCTTATG CAGGTGAGGA CAGACCCAAG GTCCAGGCAA 000400
000401 TGCTGGCCTT TGGAACACAG AACCTGGCTC ACTGACTCCC ACTCCAGTTG TCTTTTCCCT CTGCCTCTGG AGCAACCCTC 000480
000481 TCTCCTCCAG AGCAACCCCT GTCCCTCCTT CCTACCTCTC TCTAGGGCTG CACCCCCAGC TCACCTTAGA CCTGGCCCTT 000560
000561 CCTACCTGTT GCCCCTACTG TCTTGTCCCA TCCCAGTGGT CAGGAGGGAG AGTACTGGCC AAAGGCCCAG CTCCACCTGT 000640
000641 GACTTAGGGG AGTGCCAGGC ATCACCCAGA GGTCCCGGCC CTCGGGGGCC TGGCAGGCTC TGCTGTGGGG GAAGCAGAGT 000720
000721 TAGAACTGGG GCTGCTTCTC CTGTCCCCCA GCCTGGCTGG GCCTCCCCCA CCTCCCTTTC TGCCTGCCCT CTTACAACTC 000800
000801 CAGCAGGGGG CGGGCAGGGG AAAGAAAAGG AGGGACAAGT TGGATGGGGT CCATTTGGTG TCCAGGAACA ACTTGGAGAG 000880
000881 AGGCGGGGAG GGGACAGGCA GCAGGGCCCT GGCAGAGCCA GGGGAGGGCT GGCCTTTGGA TGGCCTTCTG ATCCCAAGCC 000960
000961 CATCCTCCTG GGGCAGTCTT CCCTTGAAAG GGAGGGTTTG GTGAACCCTG GTGCGGACCC CCCCGCCGGA CCTCACTGCC 001040
001041 CCAGTGCGGG GCGTGGTAGG CGGGTTTGCA ATGGGTACAG CCTCTCTCTC CATTCCAGTA GAGCAGCTCC CAGGGCCCAG 001120
001121 AGAGGCTGTC ACTGAGACTT CCCTCTGGGG TGGGGTGGGT TCTGGTGGCC CTGTGTTCCC CTGCAGGAGG ACCTCCTGAG 001200
001201 GCTTCGGGCA GGAGCTGGTG CACACCTGGA GGAGAGTGCT GGTGAATGGC AGGTGTGTGC CTCAGTGTCC TTGCTGCCAG 001280
001281 GGTGTCAGCC CTGCTTCACC ACTGGCCGTT TGTCTCTGTC CCCTCCACTG GCCTCTTGAA GCACAGAGAC CCTCCGGGTA 001360
001361 CTTTCCTTCC TCTGGGCTTC CACTCATGCT ATTCCCTGCT CCCTTTTTCT ACCTGGAGAC CCCCATTCCT CCTCCTCCTC 001440
001441 TGCTGCCCTC ACCTCCACCT GGGCCCTCCC AGCTCCCGGG AGATGGCTGA ACCCCACTCC CCACCCGCTA GTCATCCTCT 001520
001521 TCAGCGGTCC TCCCAGAGCT GTCCTCAGCA TGGCAGCCTC CACAGCCCCT GGGTGTCACC CCCGGTTTCG TGTCTGCCTC 001600
001601 GGACTCCAGA CCTGCCCCTC CCAGGCTGGC CCAGATGGAT CCTCTACAGT GACTAACCCA AACCAGCACC AGGCAGGGAC 001680
001681 CCAATAAACC TTTGTGAATG GAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAA
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Annotation (From lncRNAdb)

[NONHSAT040039]
Section Description
ID Dio3os
Characteristics Antisense and head to head with Dio3 from the Dlk1-Dio3 imprtinted locus (Hernandez (2004)). A large number of isoforms are transcribed through alternative splicing and start sites some of which overlap Dio3 (Hernandez (2004)). Also overlaps a provisional microRNA miR1247.
Expression Various DIO3OS isoforms are expressed in a wide range of human tissues including adult testis, adrenal cortex, heart, bladder, uterus, placenta and fetal lung (Hernandez (2004)). Expressed in embryonic and extra-embryonic tissue in mouse. Weakly expressed in several neonatal and adult tissues: brain and liver (adult only), intestine and tougue (neonate only), kidney and lung (expressed in both) (Tierling (2006)). Analysis in different cell culture lines showed co-expression of DIO3OS transcripts and DIO3 (Kester (2006)). Conversely differentiation of mature brown adipose tissue (BAT) adipocytes from precursor cells showed that Dio3 was only expressed in the proliferating precursors while a specific Dio3os isoform was expressed only in differentiated adipocytes (Hernandez (2007)). Not imprinted in mouse (Tierling (2006)).
Conservation Aside from the short exon 1, there is poor sequence conservation and no conserved ORFs between mouse and human Dio3os (Hernandez (2004)).

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