NPTN-IT1
NPTN-IT1, NPTN intronic transcript 1 plays a tumor-suppressive role in several types of cancer.
Contents
Annotated Information
Approved Symbol
NPTN-IT1 (NPTN intronic transcript 1)
Synonyms
lncRNA-LET: long non-coding RNA, low expression in tumor (HGNC:45091)
RefSeq ID
NR_103844
OMIM ID
615176
Ensembl ID
ENSG00000281183
Characteristics
NPTN-IT1 is a recently identified lncRNA located at chromosome 15q24.1. [2]
Function
NPTN-IT1 inhibits the metastasis of HCC and colorectal cancer cells in vivo.[1] NPTN-IT1 downregulation increase lung colonization, hepatic invasion, and abdominal metastases.[1] The association between NPTN-IT1 and NF90 enhance the degradation of NF90, thereby affecting HIF-1α mRNA accumulation and stability under hypoxic conditions without altering HIF-1α promoter transcriptional activity.[1] NPTN-IT1 expression can decrease the CDC42 and increase the DUSP1 protein levels under normoxic conditions.[1]
Regulation
Under hypoxic conditions,the downregulation of NPTN-IT1 expression is mediated by hypoxia-induced HDAC3.[1]
Expression
Compared with the normal primary tissue specimens that were collected from patients with HCC (n = 93), squamous-cell lung carcinoma (n = 10), and colon carcinoma (n = 22), the NPTN-IT1 transcripts were expressed at lower levels in the tumor tissues.[1]
Diseases
- Cervical cancer [3]
- Colorectal cancer [1]
- Gallbladder cancer [1]
- Hepatocelluar carcinoma [1]
- Nasopharyngeal carcinoma [4]
- Squamous-cell lung carcinomas [1]
Labs working on this lncRNA
- Department of Medical Genetics, Second Military Medical University, Shanghai, 200433, China. [1]
- Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Yang F, Huo XS, Yuan SX, Zhang L, Zhou WP, Wang F, Sun SH. Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis.
- ↑ Liu B, Pan C-F, He Z-C, Wang J, Wang P-L, Ma T et al. Long Noncoding RNA-LET Suppresses Tumor Growth and EMT in Lung Adenocarcinoma[J]. BioMed research international. 2016, 2016:4693471-4693471.
- ↑ Jiang S, Wang H-L & Yang J. Low expression of long non-coding RNA LET inhibits carcinogenesis of cervical cancer[J]. International journal of clinical and experimental pathology. 2015, 8(1):806-811.
- ↑ Sun Q, Liu H, Li L, Zhang S, Liu K, Liu Y et al. Long noncoding RNA-LET, which is repressed by EZH2, inhibits cell proliferation and induces apoptosis of nasopharyngeal carcinoma cell[J]. Medical Oncology. 2015, 32(9):226.
Sequence
>gi|523498743|ref|NR_103844.1| Homo sapiens NPTN intronic transcript 1 (NPTN-IT1), long non-coding RNA
000081 TGCCCCGAGG CTGTGCCCTC AAGCTGGCCT AGGGTCAGAG AAGGGAGGAG ATGGTAGCAG CAGAACCACA GCACACCACT 000160
000161 GAGCACTGGA AAGAGCAAGA GCTGAAATCT TAGGTTATTG GATATGCCTA GAGTCAGAAA AGCCTTGGGA AATTTTTGGT 000240
000241 GATCGATTTT TCCTGTGAAG GGGGAAGCTG CTGATGGAGA CTTGTATCTG CAGTACTTCA GGTTCCCAGC TGGCTCCCCA 000320
000321 TCCCCACCCT ATAACATGAC CGGCGTACAG AAATTAATTG GCCGACTGTT ACCACCACTA GTCTGTCCCT GGCTAGACTA 000400
000401 GACAGATGGG TGTGCCCCTG GGCTCAGTGG TAGCCTACCC GGGGTGATGG TGGGGTTGCC AGCTGTAGTC CAGCTGTTCT 000480
000481 GGGGCCTGTG TTTGTGCACC TGTGGTGCTG TATCCTGCCC CACAGAGCTG GCTGTCCAGT GGAGAATACA AAGTGACATC 000560
000561 TGGTGCTCCC TCAGAAAGAA TGTGGCCCCA GAGGCATGCC AGTGGCTTTA GACTCTCTGG GAGGACATGT TTGAGAGCAA 000640
000641 CAGCCCCTTC CCCATCTTTT CCTTTCTTCT CAGCAGTTAT AAATCTCTCT GCCTGCAGTA AGTAGAGTGA GTGGCTGGTG 000720
000721 AGGAGGTTTG TTGATGACAC TGACAATATC TGGTGACTCC CTCCAGATGT GCACTCAGCA GTGAGCTGGG CAGAGGCGTG 000800
000801 GGAAGGACGT TGGCTGGGAG CAGACGGCCT CTGCAAATGA ATCTCTAGTT TCCTGCAACC TGGGAGTGTC CCCATGAGTT 000880
000881 TTACTTTCCT ACTTTATGAA GTGAACCTGC TTTCTTTGGG ATTTCATGTA CTCCTAATGC TTTTTCTCTC CAGGTATTTC 000960
000961 TTTCCTGCTA CATATTAGGA CTCCCAAGGC AAGAGTGCAC CTTTATTTAG ACCTGGGAGT AAAGGGAAAG AGTTGCCTGT 001040
001041 CTTTCGTGTG TTTTCAGCTT TGGCTCTGTG GGATCAGTTA TGCCTCATTC CTGAAAAGGG CCTTTTTATC CCCCCAGAAT 001120
001121 GCTTTTGCTT TGCCAATACC ACCTTCCTCA GCCTGCCTTT TGGAAAGGTT GAGAAGCTAA AAAGTCAGGT AAGAGAAGGC 001200
001201 AGAGATGGAC TTCAGAACCT GATTTTTAAA TTTTAAGGCA AGGCTGGCTG CCACTGGTGA GAGTGATGCA GCAGCCTAGC 001280
001281 GTGTTCCCAG CAGAGGTCTA GTCTTTGCCC TAAGAAGTCA CCGCGCTTAT GAGGTTGCTA TCACAGTGCA TGTGGTAGGT 001360
001361 TAGATTTGAG AAATGGTTAG GATTGTTCTG TTGGATAAGT GCAGACACCT GCCCAGGGAA GCAGCTCTTT TTTTGTAAGA 001440
001441 GTTTTCTTGG TTACTGAAAT CAAATGGGGG ACCAGTTTGT TATAGGAGAC ATCTGTGGCC AGCAAATCTG AACAGCTTCC 001520
001521 TAGAGGGAAA GTACCTCTTT TAAACTAAGT TATTATAGAC AGTGAATGAA TCCTACCCTT AAAAGAGATG ACGGCAGGGT 001600
001601 AAGTGCAAAG TAAAACCTCC TTGCTCTAGT CTCTTGGGAG AGTATTGTAA TGAAAGCAGC GTTTACTTCG TTGTTGTTGC 001680
001681 ATTGGGGTGA AAAATCTGAG ATGCTGGAAT GATGGCAATG TTTGCCTTCT CTCCTTCCCT TCCTGACAGC CAGTGTGGGC 001760
001761 CAGGCTCCAC TCTCCATCTT CACACCCTGC CCTTGCTCCA GTATTTCCAT TCTGTTTTTC TCCTCTGTCT CTTTCTGTCT 001840
001841 TTCTCTCAAA CTCCATCCTG CTTCCACCCC TGCCCGCTTT TCTTCTCCTT TCCTGGAAGT AATCATTAAA CAAAAGAAAA 001920
001921 AGTTGAATGT TCTTTGGTGA GTTTCCTTCT TCTCTGCCTT TTCCTTCTTT AGCCAGTTCC CCTCAACCCC TGTGCACTCC 002000
002001 ATAGGAAGGA CAAACTTACC TGTCTGCTTC CTTCCCATGT GCTTCTCCCC AAATTTTCAT ATAGATATAT ACGTACACTC 002080
002081 CTTTTGGAAT AAACGAAGAG GTACATTATA TTTGACACAA ACTTGGGAGT GTTAAGAGGT CATAAGTGTT TACCTATCAG 002160
002161 ATAACCATCT GTGGCTCTGT GTTGGATTTT TTTTATACCA TTAGGAAAAT GGGAATTTTT TTATAGGCCT GCCATACTTC 002240
002241 TACTTTGCCA AATAGCACTT TATTATCAAG ATACACCCAT GGCTCATTTC AGACTCACTG AACTTTTTTT ATATGAATGC 002320
002321 ACAGTCGTCA TATTTTGGGC AGTCTGTGAG TTCTTGGTAA CTCATCCCCT TACTACAAAA GCACTAAGTG AACAATACAA 002400
002401 AAGTATAAAA GCACAAATTT GAACTTACAT AGTTTAGTTT AAGTATGTTT CACTAGAAAA TCAAATATTT AGATTTCTCA 002480
002481 CATTGAAAAT GCTTAGGATT GAGGTTTAGC TGCTTCCTTT AAAAAAAAAA AAAAAAAAAA AGCCCCATGT CTTTTTTCTT 002560
002561 TACCTACTGG AGTATTCTCA GACCATTTCC TACATGAAAA CACCCA
