Difference between revisions of "PCAT18"
| Line 11: | Line 11: | ||
===Ensembl ID=== | ===Ensembl ID=== | ||
ENSG00000265369 | ENSG00000265369 | ||
| − | + | ||
| − | |||
===Expression=== | ===Expression=== | ||
| − | PCAT18 expression | + | PCAT18 is specifically expressed in prostate and prostate cancer (PCa) <ref name="ref1" />. It is up-regulated in prostate cancer (PCa) comparing with benign prostatic hyperplasia samples, and is significantly up-regulated in metastatic PCa comparing with nonmetastatic PCa <ref name="ref1" />. In addition, PCAT18 expression is higher in androgen receptor (AR) positive than in AR-negative PCa cells <ref name="ref1" />. |
===Function=== | ===Function=== | ||
| − | PCAT18 is a potential therapeutic target and biomarker for metastatic PCa.<ref name="ref1" /> | + | PCAT18 is a potential therapeutic target and biomarker for metastatic prostate cancer (PCa) <ref name="ref1" />. PCAT18 silencing significantly inhibits |
| + | PCa cell proliferation and triggered caspase 3/7 activation, with no effect on nonneoplastic cells. PCAT18 silencing also inhibits PCa cell migration and | ||
| + | invasion <ref name="ref1" />. | ||
| + | |||
| + | ===Regulation=== | ||
| + | PCAT18-associated expression signature is significantly associated with AR signalling <ref name="ref1" />. | ||
| + | |||
| + | ===Disease=== | ||
| + | Metastatic prostate cancer <ref name="ref1" /> | ||
==Labs working on this lncRNA== | ==Labs working on this lncRNA== | ||
Revision as of 04:03, 27 November 2017
Contents
Annotated Information
Approved Symbol
PCAT18 (prostate cancer associated transcript 18 (non-protein coding))
Synonyms
LINC01092
PCAT18 expression [1].
Chromosome
18q11.2
RefSeq ID
NR_024259
Ensembl ID
ENSG00000265369
Expression
PCAT18 is specifically expressed in prostate and prostate cancer (PCa) [1]. It is up-regulated in prostate cancer (PCa) comparing with benign prostatic hyperplasia samples, and is significantly up-regulated in metastatic PCa comparing with nonmetastatic PCa [1]. In addition, PCAT18 expression is higher in androgen receptor (AR) positive than in AR-negative PCa cells [1].
Function
PCAT18 is a potential therapeutic target and biomarker for metastatic prostate cancer (PCa) [1]. PCAT18 silencing significantly inhibits PCa cell proliferation and triggered caspase 3/7 activation, with no effect on nonneoplastic cells. PCAT18 silencing also inhibits PCa cell migration and invasion [1].
Regulation
PCAT18-associated expression signature is significantly associated with AR signalling [1].
Disease
Metastatic prostate cancer [1]
Labs working on this lncRNA
- Experimental Therapeutics, BC Cancer Agency Cancer Research Centre, Vancouver BC, Canada.
References
Sequence
>gi|209969705|ref|NR_024259.1| Homo sapiens prostate cancer associated transcript 18 (non-protein coding) (PCAT18), long non-coding RNA
000001 CTTTTTCTTC GTAACTTCAT GGCAACATGA CCTACAGTTA CTCATTTTTC AGGCCTGAGT TGATCGTTAA TCATCTTAAT 000080
000081 TATGTTCATT CTGAAGCCAA CAGGAGAACC AAGACCAAAA CTTTATTGTC TCTGCTTTCA TTTCTTGATG AAACCTCTGG 000160
000161 ACTAAGCACA CATCTTCCTT GTTTATCTCT CTCAAAGGAG TGTGGAGTGC TTCATCTGGA CATCCACGGG AAGAAGGAAG 000240
000241 ACATGAGGGA ATGCTGGAAG AGGAGACAGG CCCCAGATTT GGGCAGGAAG TAAACAGTTT TCAGGCTGAG GCCAATCTGA 000320
000321 GCAGGAACAT TCCAATATTT CTTCAGCTAC GTTGTCCCAG CACTTCACTG GTTAACCTTT TATGTCCACC ATTTGTGGAT 000400
000401 TTCACAGCTA CTTGTCAATG GTGAATATTG ATCATCATCA TTATCTACTG AGCTGCTACC ATATCCCAGC TACTCCTTGC 000480
000481 ATGTTGTTCA TTATTTTCTC AACACTCAGC ATATTTGCAA TATGTTATGT AATATCACAG ACAAGGAAAC TGAACGCAGA 000560
000561 AATGTTTTAT TTCTTGCCAA ACATCACATG AGGATGAACA ATGAAACCGA TTTGAAACCA GGATTGTCTG ATTCCAACAT 000640
000641 CTCTGGGTCC TTTTTCACTC TGATATGCTG CAATTAAAAA GCCATTTCTA AGACTGTACG TTCCAAGATT GTTTCTATAG 000720
000721 TTGGTTGTGA GAGAAGTTTC TCTGAACTTG CAGAGCACGG GAAACCAGGA GGAGGAGGCT CAGGGTGCTC TCCACACGTG 000800
000801 TGAAACCGGC TGTGGGTGTT GCTTTCCTGT GACTGCCATT TGCCACTGAT GATCTTCTCT TCCTCTGGAA GAGTAAGAGG 000880
000881 GGGAAGGACA CAGTTTCAGT GCTTCCCATT TATAATTAAT TAATTAATTA AGGGCAGGTG CAGGGGCTCA CACTTGTAAC 000960
000961 CCCAGCACTT TAGGAGATTG AGCAAGGAGG ATCCCCTGAG CCTGGGAGTT TGAGATCAGC CTGGGAAGCA GAGTGAGACC 001040
001041 ATGACTTAAA TAAAAATTTT TTTGTGTTTT GTTCTAATTT TTACTTTTTT GAGACAGGGT CTCGCTCTGT TGCCCAGGCT 001120
001121 GGAGTGCAGT AGCGTGATCT CAGCTCACTG CAACCTCTGC CTCTGGGTTC AAACAATTCT CATGCCTCAG CCTCCCAAGT 001200
001201 AGCTGGGATT ACAGGTGCCT GCCACCATGC CCAACTAATT TTTTTGTACT TTTAGTAGAG ACGGGTTTTC ACCATGTTGG 001280
001281 TTGGCCAGGC TGGTCTCGAA CTCCTGACCT CAAGTGATCC GCCCACCTCA GCCTCCCAAA GTGCTGGGAT TACAGGCATG 001360
001361 AGCCACCACG CCCGACCAAA AAAAAATTTT TTTTTTTCAA TTAGCCAGAC ATTGTGGCAT GTGCCTGTAG TCGCAGCTAC 001440
001441 CATGGGGGCT GAGGTGGGAG GATAGCTTGA GCCCAGGAGT TTGAAACCAG CCTGGGCAGC AAAGTGAGAC CCTGCCTCAA 001520
001521 AAATAAAAAA TAAAAAAAAA GCTATTTCTT ACAGATATTC ATTGAGTGGA AAGCAATTTA ATTTTACGTA TAATAAGTTA 001600
001601 TTTCAAAAAG AATTGTAGTT ATGTGTGGCA ATTTTTCATA AATACCTGAT ACAAATCAAG ATCTACCATG GTAAGTGTGC 001680
001681 TCCAGAGATA CCCTTCTTGA CCAAAACAAA GCAGGGCAGG GATTGGGAGG CCTTTTGGGC TGGGCTCCAG GACACAATGA 001760
001761 CTAGAAGATG ATGCAAAGTG CATGACAGAG TAGAGAGCTA CACAGTTTAC ACATATTAGA CTCTGCACAT ATTAGAGTCT 001840
001841 ACACATATTA GACTCTGCAA AAGTAGTTCT TAAATGTTAG CTCACATGCA CCCCAGTCAC GTTACTGAGC AGATTCCTGG 001920
001921 GCTCCAGTCC TGGGTGATTC TTGCAGGTGG TCCATTGACC AGATTAGGAG AATCATCATC CAAGGTCTCA AAGCCAAATT 002000
002001 TAGGACGCAG AGAGAAAGAA TCCTAAGTGG TTGAATGGGA AACTGATTCT CCTCTTGAGC ACACCTTAGA TTCAAATAAT 002080
002081 TGATTGGAGA AGATCATTCC ATACAAAAAT CTTCTGACCT GCAGAGTTTC TACAAAAAGT CTTGAGAAAG AAAAAGAAAA 002160
002161 ACATATATTT TTGGAAAAGA TTGAATTTAA TTATAATTTT GCAAATTATA CTGTGGGAAA GGTCAACAAA AACAAGCGTA 002240
002241 TTGCGGATGA TCTTATAAAA AGAACCTTTT GTAAAGTAAA CAATTACCTT CTGATTTGTC TACTCTGAAC CCTTGATGTT 002320
002321 TATTTAAATT GGATGTTCTC ATAGCAGGAC ACACCTGATA CCTGGCTTGT CTAAACACTT AGAAAGTCAA ATTGTCTAGT 002400
002401 TATCAAAGCC CAGGCTTATT TTCTAAATAA GTATGGATGG TCTTTCAGGA GTCATTTCAC AGTGATGTGC AGAGAGAAAA 002480
002481 ACAATACAAA CAAACAAACA AACAAACAAA AAACAAATCA TTGTTCCTAA GTGTGTTTTC CAGCCTATGT CTAACTTTCT 002560
002561 AGCAGATAAT GGCAATAAAA ATGTTTGGGT CCAACATT
000081 TATGTTCATT CTGAAGCCAA CAGGAGAACC AAGACCAAAA CTTTATTGTC TCTGCTTTCA TTTCTTGATG AAACCTCTGG 000160
000161 ACTAAGCACA CATCTTCCTT GTTTATCTCT CTCAAAGGAG TGTGGAGTGC TTCATCTGGA CATCCACGGG AAGAAGGAAG 000240
000241 ACATGAGGGA ATGCTGGAAG AGGAGACAGG CCCCAGATTT GGGCAGGAAG TAAACAGTTT TCAGGCTGAG GCCAATCTGA 000320
000321 GCAGGAACAT TCCAATATTT CTTCAGCTAC GTTGTCCCAG CACTTCACTG GTTAACCTTT TATGTCCACC ATTTGTGGAT 000400
000401 TTCACAGCTA CTTGTCAATG GTGAATATTG ATCATCATCA TTATCTACTG AGCTGCTACC ATATCCCAGC TACTCCTTGC 000480
000481 ATGTTGTTCA TTATTTTCTC AACACTCAGC ATATTTGCAA TATGTTATGT AATATCACAG ACAAGGAAAC TGAACGCAGA 000560
000561 AATGTTTTAT TTCTTGCCAA ACATCACATG AGGATGAACA ATGAAACCGA TTTGAAACCA GGATTGTCTG ATTCCAACAT 000640
000641 CTCTGGGTCC TTTTTCACTC TGATATGCTG CAATTAAAAA GCCATTTCTA AGACTGTACG TTCCAAGATT GTTTCTATAG 000720
000721 TTGGTTGTGA GAGAAGTTTC TCTGAACTTG CAGAGCACGG GAAACCAGGA GGAGGAGGCT CAGGGTGCTC TCCACACGTG 000800
000801 TGAAACCGGC TGTGGGTGTT GCTTTCCTGT GACTGCCATT TGCCACTGAT GATCTTCTCT TCCTCTGGAA GAGTAAGAGG 000880
000881 GGGAAGGACA CAGTTTCAGT GCTTCCCATT TATAATTAAT TAATTAATTA AGGGCAGGTG CAGGGGCTCA CACTTGTAAC 000960
000961 CCCAGCACTT TAGGAGATTG AGCAAGGAGG ATCCCCTGAG CCTGGGAGTT TGAGATCAGC CTGGGAAGCA GAGTGAGACC 001040
001041 ATGACTTAAA TAAAAATTTT TTTGTGTTTT GTTCTAATTT TTACTTTTTT GAGACAGGGT CTCGCTCTGT TGCCCAGGCT 001120
001121 GGAGTGCAGT AGCGTGATCT CAGCTCACTG CAACCTCTGC CTCTGGGTTC AAACAATTCT CATGCCTCAG CCTCCCAAGT 001200
001201 AGCTGGGATT ACAGGTGCCT GCCACCATGC CCAACTAATT TTTTTGTACT TTTAGTAGAG ACGGGTTTTC ACCATGTTGG 001280
001281 TTGGCCAGGC TGGTCTCGAA CTCCTGACCT CAAGTGATCC GCCCACCTCA GCCTCCCAAA GTGCTGGGAT TACAGGCATG 001360
001361 AGCCACCACG CCCGACCAAA AAAAAATTTT TTTTTTTCAA TTAGCCAGAC ATTGTGGCAT GTGCCTGTAG TCGCAGCTAC 001440
001441 CATGGGGGCT GAGGTGGGAG GATAGCTTGA GCCCAGGAGT TTGAAACCAG CCTGGGCAGC AAAGTGAGAC CCTGCCTCAA 001520
001521 AAATAAAAAA TAAAAAAAAA GCTATTTCTT ACAGATATTC ATTGAGTGGA AAGCAATTTA ATTTTACGTA TAATAAGTTA 001600
001601 TTTCAAAAAG AATTGTAGTT ATGTGTGGCA ATTTTTCATA AATACCTGAT ACAAATCAAG ATCTACCATG GTAAGTGTGC 001680
001681 TCCAGAGATA CCCTTCTTGA CCAAAACAAA GCAGGGCAGG GATTGGGAGG CCTTTTGGGC TGGGCTCCAG GACACAATGA 001760
001761 CTAGAAGATG ATGCAAAGTG CATGACAGAG TAGAGAGCTA CACAGTTTAC ACATATTAGA CTCTGCACAT ATTAGAGTCT 001840
001841 ACACATATTA GACTCTGCAA AAGTAGTTCT TAAATGTTAG CTCACATGCA CCCCAGTCAC GTTACTGAGC AGATTCCTGG 001920
001921 GCTCCAGTCC TGGGTGATTC TTGCAGGTGG TCCATTGACC AGATTAGGAG AATCATCATC CAAGGTCTCA AAGCCAAATT 002000
002001 TAGGACGCAG AGAGAAAGAA TCCTAAGTGG TTGAATGGGA AACTGATTCT CCTCTTGAGC ACACCTTAGA TTCAAATAAT 002080
002081 TGATTGGAGA AGATCATTCC ATACAAAAAT CTTCTGACCT GCAGAGTTTC TACAAAAAGT CTTGAGAAAG AAAAAGAAAA 002160
002161 ACATATATTT TTGGAAAAGA TTGAATTTAA TTATAATTTT GCAAATTATA CTGTGGGAAA GGTCAACAAA AACAAGCGTA 002240
002241 TTGCGGATGA TCTTATAAAA AGAACCTTTT GTAAAGTAAA CAATTACCTT CTGATTTGTC TACTCTGAAC CCTTGATGTT 002320
002321 TATTTAAATT GGATGTTCTC ATAGCAGGAC ACACCTGATA CCTGGCTTGT CTAAACACTT AGAAAGTCAA ATTGTCTAGT 002400
002401 TATCAAAGCC CAGGCTTATT TTCTAAATAA GTATGGATGG TCTTTCAGGA GTCATTTCAC AGTGATGTGC AGAGAGAAAA 002480
002481 ACAATACAAA CAAACAAACA AACAAACAAA AAACAAATCA TTGTTCCTAA GTGTGTTTTC CAGCCTATGT CTAACTTTCT 002560
002561 AGCAGATAAT GGCAATAAAA ATGTTTGGGT CCAACATT
