RN7SL1

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RN7SL1,transcribed by RNA polymerase III, influences transcription activity.[1][2]

Annotated Information

Name

Approved symbol:RN7SL1

Approved name:RNA component of signal recognition particle 7SL1

HGNC ID:10038

Previous name:RNA, 7SL, cytoplasmic|RNA, 7SL, cytoplasmic 1

Alias symbol:7SL|7L1a|RNSRP1

RefSeq ID:NR_002715

LncBook ID:HSALNG014164

Prev_symbol:RN7SL

Characteristics

The RN7SL1 locus is an authentic 7SL RNA gene encoding one of the three sequence variants of human 7SL RNA.[1] Comparison of the upstream regions revealed the presence of two conserved elements in the two human RN7SL1 genes, an ATF/CRE binding site at -43 to -50 and a TATA-like box centered around position -25.[2]

Function

Two sequence motifs can be identified in RN7SL1 at positions 10-19 and 50-60, respectively, downstream of the transcription start site that resemble putative A and B boxes. Single and multiple nucleotide substitutions in these regions also influenced transcription activity to a great extent.[2]

Expression

RN7SL1 is expressed in HeLa cells.[1]

Diseases

Human skin diseases[1]

Labs working on this lncRNA

  • Department of Molecular Biophysics and Biochemistry, Yale University,P.O. Box 3333, New Haven, CT 06510, USA.[1]
  • Institut für Biochemie, Universität Würzburg, Biozentrum, Am Hubland, D-97074 Würzburg, Germany.[2]

References

  1. 1.0 1.1 1.2 1.3 1.4 Ullu E, Weiner AM. Human genes and pseudogenes for the 7SL RNA component of signal recognition particle. EMBO J. 1984 Dec 20;3(13):3303-10.
  2. 2.0 2.1 2.2 2.3 Englert M, Felis M, Junker V, Beier H. Novel upstream and intragenic control elements for the RNA polymerase III-dependent transcription of human 7SL RNA genes. Biochimie. 2004 Dec;86(12):867-74. doi: 10.1016/j.biochi.2004.10.012.