ZNF674-AS1
Contents
Annotated Information
Name
ZNF674-AS1:ZNF674 antisense RNA 1 (head to head)
Characteristics
ZNF674 antisense RNA 1 (ZNF674-AS1, NR_015378), located at Xp11.23, is a novel lncRNA that was identified from a lncRNA microarray analysis.[1]
Function
The ZNF674-AS1 levels are associated with clinical stage(p=0.039), histopathologic grade(p=0.045), and cancer distal metastasis(p=0.041). And lower expression of ZNF674-AS1 is correlated with the adverse survival of patients with HCC.[1]
Expression
The expression level of ZNF674-AS1 in cancer tissues from patients with HCC(Hepatocellular carcinoma) is significantly lower than those in matched normal tissues (p<0.01). Furthermore, the expression of ZNF674-AS1 is decreased in 72%(99/137) of HCC tissues compared with that in matched normal tissues. The expression of ZNF674-AS1 in five HCC cell lines(HCCLM3, SK-Hep1, HuH7, Hep3B, and MHCC97H) is also significantly downregulated compared with that in the normal liver cell line QSG-7701. Taken together, ZNF674-AS1 is Downregulated in HCC Cell Lines and Tissues.[1]
Diseases
Hepatocellular carcinoma[1]
Sequence
>NR_015378.3 Homo sapiens ZNF674 antisense RNA 1 (head to head) (ZNF674-AS1), long non-coding RNA
000081 CAGTGGTTAT GACAGTGTTC GCTCTAAGGG GAGAAGGAAT GTGTGACCAT TTCCAACGGT TAACTTGCAT TCCCCAGATA 000160
000161 GTTTGGATGA GTTACAACCT AAATCTGCAA ACTCAATACA GCCAGACCCT GGGAAGTGAC TCTCTCCAAG CCTCCTGTAC 000240
000241 AAGTCCCAGG AAAAGAGCCT GTTTTCCCTT GGACATGTGA GCAGTGAATT ACTGCTCATT CAGAATTTCA TGTGTATGTG 000320
000321 TTACTGATGG CCAGGTTTAG AGATACCAAC CTATTTATTT CTAGAGGAGA GGTGATTTGA TAACCTTTTC AGATATCACT 000400
000401 ATCAGTAGGC AGAAAAGGGT TAATAGTATG ATAGGGTTAA TATGTCCTGA GGAGAGTAAA GAAATTGCAA ACTGCAGAAG 000480
000481 CACCTGATCT GTGGCCCTGG CCAGCATCTC TCCATATCCT GATTCTGTAA GATCAAGTGT TTATGCAGAA AGAGAAGGGA 000560
000561 CTGATGATTT GAATGTGACC AGATGCAGGG CATGCCCTTA TTGCCATGCC AGCATTTGCT ATTCATGATG TTAGTATTCA 000640
000641 AAAATCAAGA AACACCCTTC CTGGGCCATT GGTGTCTACT AATCCATTGG AAGAAAAGAC TGGAATCCAC CACTTACTAG 000720
000721 CTTCTTGGGC CTCAGTCCCC TCTTTTCTGC CATAGCTAAG GACCACCTAA CCTAGATGGC TGTTGTTATT GTTCAAAGGG 000800
000801 ACATCTTTAG AGCCTCAAGC CCAGGAATAG CCCGTGGCAG GCACCTGGTA AATGTTAGTT TTCATTGTCC TATCCCAACA 000880
000881 CTATGAAACA TGCAGCACTC TCTGCAACTG CCCCTGTGGA TTTCCATAGG CAGGAGAGTA TCCAGTGTTG AGTGGAGCTG 000960
000961 GTATTCTCAG AAACGAAGCC CCTTTCCTCA TTTTGCGCCA ATCTCTTCAG TCATTTTTAC CCTAGTAGTA TAATGCTTTG 001040
001041 TCAAAGTCAC TGTCATCTGA TGTTAACAGT TGTTTTCGCC AGATGACTTT TCAAAAGGTA ACTTCACCAT AATACCGGTT 001120
001121 AATGTGATAA AAACACTGCA TGTAGCCAAT TTTTTTTTTT TTTGAGATGG AGTTATTGGC TCTTGTTGCC CAGGCTAGAG 001200
001201 TGCAGCGGCG TGATCTTGGC TCACTGCAAC CTCCATCTCG TGGGTTCAGG TAATTCTCCT GCCTCAGCCT CCCGAGTGGC 001280
001281 TGGGATTACA GGCACACGCC ACCATGCCCA GCTAATTTTT TTGTATTTTT AGTAGAGTCG GGGTTTCACT ATATGTTGGC 001360
001361 CAGGCTGGTC TCGAACTCCT GACCTCAGGT GATCCGCCTG CCTCAGCCTT CCAAAGTGCT GGGGTTACAG GTGTGAGCCA 001440
001441 CTGCACCCAG CCAAATATTT TCTTATTTAT TTATTTATTT TAGAGACAGG ATGCCATTAT GTTGCCTAGT TTGGAATGCA 001520
001521 GTGTCTATTT AGAGGCGTGA TCATGGCATA CTATAGCCTC GGCTCAAAGG ACCCTGGTCT CAAAGGACCC TGCCACCTTA 001600
001601 GCCTCCTGAG TAGCTGGGAC AAGTGTGCGC CACCACACCT GGCTAATTTT TTAAATTTTT TGTAGAGATA GTGTCTCGCT 001680
001681 ATGTTGCCCA CGCTGGTCTG GAATTCCTGG ACTCAAGGCC TCTTCCTGCC CTCAGACTTC CAAAGTGTTA GGATTACAGG 001760
001761 GTGAGTCACC ACGCCCAGCC AGTGTGAATT TTCTAATGCT GAGTAAGTTG TGATCCAGAA GTAAATGTAT CTGCAAGCTG 001840
001841 ATTTAAATTG TAGATTTTCT CTTCATTGCA TATTTTCTGA TGTTGAATAA AGTCTGAGTA TTAACTAAAG TTTTTGCTTC 001920
001921 TTAAATATGT AAGAATTGTC CTCAAAATCT CTATTCTTGA GCACAGTAGT AAAAATATTT TTACATACAT TGTATTTCAA 002000
002001 GGGTTCTGCA TAAGCAACCT TGTTTTATTG TGACAATTTA TTTGGGAATT GTATCAAATA TATAATACTG AGATGTTCTC 002080
002081 ATTCCTTTTG TGAAAATACT TTTGTTTAAA AACCACTGCC TTCAAATGAA AACCACTAGG TTTGTTAT
Labs working on this lncRNA
- Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Zhang L, He T, Yan Y, Zhang Y, Zhou X, Huang P, Kong Y, Xie M, Zhang L, Sun Q, Zhou D, Xie H, Zhou L, Zheng S, Wang W. Expression and Clinical Significance of the Novel Long Noncoding RNA ZNF674-AS1 in Human Hepatocellular Carcinoma. Biomed Res Int. 2016;2016:3608914. Epub 2016 Nov 8.
