Subcellular Relocalization Landscape of the Brain Proteome in Down Syndrome Reveals Nuclear-Cytoplasmic Shifts Associated with Neuropathology
| Title | Subcellular Relocalization Landscape of the Brain Proteome in Down Syndrome Reveals Nuclear-Cytoplasmic Shifts Associated with Neuropathology |
|---|---|
| Description | Down syndrome (DS), caused by trisomy 21, remains poorly understood at the molecular level, particularly regarding the role of abnormal protein subcellular localization in its pathogenesis. This study systematically analyzes proteomic data from DS brain tissue, revealing significant nuclear-cytoplasmic redistribution of 150 proteins, including key factors like SGO2 and TOP2A, which translocate from the nucleus to the cytoplasm. These proteins were enriched in cell cycle-related pathways, particularly sister chromatid segregation. SGO2 was identified as a central hub in protein interaction networks, suggesting that its nuclear mislocalization may disrupt chromosome segregation and genome stability, contributing to DS pathology. By integrating existing literature, we mapped the pathway network through which nucleocytoplasmic redistribution affects chromosome segregation, offering new insights into DS's regulatory mechanisms. |
| Organism | Homo sapiens |
| Data Type | Proteomic Data by Mass Spectrometry (MS) |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA044873 |
| Release Date | 2028-08-01 |
| Submission Date | 2025-08-19 |
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix |
|---|---|---|---|---|---|
| OMIX011498-01 | T21-1-C | 1 | Proteomic Data by Mass Spectrometry (MS) | 5.18 GB | d.zip |
| OMIX011498-02 | T21-2-C | 1 | Proteomic Data by Mass Spectrometry (MS) | 5.02 GB | d.zip |
| OMIX011498-03 | NC-3-C | 1 | Proteomic Data by Mass Spectrometry (MS) | 4.66 GB | d.zip |
| OMIX011498-04 | NC-3-N | 1 | Proteomic Data by Mass Spectrometry (MS) | 5.06 GB | d.zip |
| OMIX011498-05 | NC-1-C | 1 | Proteomic Data by Mass Spectrometry (MS) | 4.9 GB | d.zip |
| OMIX011498-06 | T21-3-C | 1 | Proteomic Data by Mass Spectrometry (MS) | 4.67 GB | d.zip |
| OMIX011498-07 | NC-2-N | 1 | Proteomic Data by Mass Spectrometry (MS) | 5.32 GB | d.zip |
| OMIX011498-08 | NC-1-N | 1 | Proteomic Data by Mass Spectrometry (MS) | 4.95 GB | d.zip |
| OMIX011498-09 | NC-2-C | 1 | Proteomic Data by Mass Spectrometry (MS) | 5.04 GB | d.zip |
| OMIX011498-10 | T21-2-N | 1 | Proteomic Data by Mass Spectrometry (MS) | 4.59 GB | d.zip |
| OMIX011498-11 | T21-1-N | 1 | Proteomic Data by Mass Spectrometry (MS) | 5.08 GB | d.zip |
| OMIX011498-12 | T21-3-N | 1 | Proteomic Data by Mass Spectrometry (MS) | 4.54 GB | d.zip |