Evaluation of circulating extracellular vesicles and their miRNA contents in neutered and obese female dogs
| Title | Evaluation of circulating extracellular vesicles and their miRNA contents in neutered and obese female dogs |
|---|---|
| Description | Adipose tissue is a metabolic and endocrine organ, and its adipocytes can synthesize and secrete extracellular vesicles (EVs), thus allowing intercellular communication. EVs are nanoparticles that transport lipids, proteins, metabolites, and nucleic acids (mRNA and microRNAs). MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression. miR-132, miR-26b, and miR-155 are associated with obesity, lipid metabolism and adipogenesis. The aim of this study was to evaluate the size, concentration, and content of miRNAs (miR-132, miR-26b, and miR-155) in serum EVs from obese female dogs. Thirty-two neutered females in good general condition were recruited, including 21 obese and 11 healthy controls. |
| Organism | Canis lupus |
| Data Type | - |
| Data Accessibility | Open-access |
| BioProject | PRJCA009772 |
| Release Date | 2022-06-01 |
| Submitter | Paola Silva Nunes (paolacarolsilva@gmail.com) |
| Organization | University of São Paulo, Brazil |
| Submission Date | 2022-05-31 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX001212-52-01 | Primer sequences | 32 | MircoRNA Microarray | 9.8 KB | xlsx | 0 | |
| OMIX001212-01-02 | Animal | 32 | Clinical information | 11.6 KB | xlsx | 0 | |
| OMIX001212-99-03 | antibodies western blotting | 32 | others | 10.0 KB | xlsx | 0 |