Semi-mechanistic population pharmacokinetics analysis reveals distinct CYP2C19 dependency in the bioactivation of vicagrel and clopidogrel to active metabolite
| Title | Semi-mechanistic population pharmacokinetics analysis reveals distinct CYP2C19 dependency in the bioactivation of vicagrel and clopidogrel to active metabolite |
|---|---|
| Description | Vicagrel is a novel antiplatelet drug used to mitigate clopidogrel resistance due to CYP2C19 polymorphism. This study aimed to develop a semi-mechanistic population pharmacokinetic (PopPK) model to characterize the pharmacokinetic (PK) profile of M15-2, the active metabolite of vicagrel and clopidogrel, and to evaluate the influence of CYP2C19 polymorphisms and other covariates in healthy subjects and patients with acute coronary syndrome (ACS) after oral administration. |
| Organism | Homo sapiens |
| Data Type | Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA011295 |
| Release Date | 2024-08-19 |
| Submitter | Xiaojuan Lai (lai_xiaojuan@vcarepharmatech.com) |
| Organization | Jiangsu Vcare PharmaTech Co.,Ltd. |
| Submission Date | 2022-08-19 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX001634-02 | Semi-mechanistic Population PK Analysis of Vicagrel and Clopidogrel to Active Metabolite M15-2 | 1 | Metabolome Data by Mass Spectrometry (MS) | 2.1 MB | docx | 0 | Controlled |