| Title |
Detect EGFR T790M mutation in ctDNA of Chinese Advanced/Metastatic NSCLC Patients by Cobas, Super-ARMS, digital PCR and NGS and evaluate clinical outcomes of T790M mutation positive patients who had AZD9291 monotherapy |
| Description |
This is an open-label, multi-center testing and treatment study in 250 locally advanced or metastatic Non-Small Cell Lung Cancer (NSCLC) patients with documented epidermal growth factor receptor (EGFR) sensitive mutation and progression (PD) on previous EGFRTKI. T790M mutation in plasma ctDNA will be tested by four methods including Roche Cobas, Super-ARMS, digital PCR and NGS in order to compare the detection methodology and clinical outcomes of T790M mutation positive (by any one of the four platforms) patients who receive AZD9291 monotherapy in ASTRIS study will be evaluated and combined with the testing results |
| Organism |
Homo sapiens |
| Data Type |
Biomarker Data |
| Data Accessibility |
Controlled-access |
| BioProject |
PRJCA011383 |
| Release Date |
2024-12-23 |
| Submitter |
chunmei xie (mayxiechunmei@126.com) |
| Organization |
Guangdong Provincial People's Hospital |
| Submission Date |
2022-08-23 |