The Metabolome analysis of 26 patients by liquid chromatography-tandem mass spectrometry (LC-MS/MS)
| Title | The Metabolome analysis of 26 patients by liquid chromatography-tandem mass spectrometry (LC-MS/MS) |
|---|---|
| Description | In univariate analysis, we observed that patients who had a history of primary refractory disease showed a worse response to 7 x19 CAR T cell therapy, suggesting that certain patient-related factors may also affect the clinical efficacy of 7 x 19 CAR T cells. Considering that metabolic reprogramming is imperative for CAR T cell function and high metabolic demands of cancer cells in patients may compromise the anti-tumor activity of CAR T cells30,31, we investigated the possibility that metabolic status of R/R LBCL patients may affect the efficacy of 7 x 19 CAR T cell therapy. Metabolome profiles in 20 responders and 6 nonresponders before or at 1, 2, and 4 weeks post-infusion were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). |
| Organism | Homo sapiens |
| Data Type | Lipidome Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA012288 |
| Release Date | 2023-03-30 |
| Submitter | Wenbin Qian (qianwenb@aliyun.com) |
| Organization | The Second Affiliated Hospital, Zhejiang University School of Medicine |
| Submission Date | 2022-10-04 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX002007-01 | exp_diff_detail_20220127 | 1 | Lipidome Data by Mass Spectrometry (MS) | 1.9 MB | xls | 0 |