The effect of Tumor-edrived exosomes on CAR-T
| Title | The effect of Tumor-edrived exosomes on CAR-T |
|---|---|
| Description | In this study, we demonstrated that lymphoma-derived TEX induces the activation of CAR T cells, which is dependent on exosomal CD19 molecule stimulation. CD19 CAR T cells short term primed with Raji-TEXs are therapeutically superior to unprimed CAR T cells in a mice model of Raij Rab27a-/- cells. However, lymphoma TEX may subsequently induces CAR T cell apoptosis and impair tumor cytotoxicity of CAR T cells with upregulated expression of inhibitory receptors PD-1, TIM3, and LAG3 under longer exposure. More importantly, ScRNA-seq revealed that CAR T cells typically showed more differentiated phenotypes and conversiong of Treg phenotype. |
| Organism | Homo sapiens |
| Data Type | Other Type of Genomic Data |
| Data Accessibility | Open-access |
| BioProject | PRJCA012289 |
| Release Date | 2023-03-30 |
| Submitter | Wenbin Qian (qianwenb@aliyun.com) |
| Organization | The Second Affiliated Hospital, Zhejiang University School of Medicine |
| Submission Date | 2022-10-08 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX002027-01 | pbmc.markers | 1 | Other Type of Genomic Data | 415.7 KB | xlsx | 0 |