OMIX002264

1Summary
Title Phosphoproteomics datasets of Integrated Proteogenomic Characterization across Major Histological Types of Pituitary Neuroendocrine Tumors
Description Pituitary neuroendocrine tumor (PitNET) is one of the most common intracranial tumors. Here, we performed the largest integrative genomics, transcriptomics, proteomics, and phosphoproteomics analysis reported to date in a cohort of 200 PitNET patients. Genomics data indicated that GNAS copy number gain can serve as a reliable diagnostic marker for hyperproliferation of the PIT1 lineage. Proteomics-based classification of PitNETs identified 7 clusters, among which, tumors overexpressing epithelial-mesenchymal transition (EMT) markers clustered into a more invasive subgroup. Further analysis identified potential therapeutic targets, including CDK6, TWIST1, EGFR, and VEGFR2, for different clusters. Immune subtyping to explore the potential for application of immunotherapy in PitNET identified an association between alterations in the JAK1-STAT1-PDL1 axis and immune exhaustion and between changes in the JAK3-STAT6-FOS/JUN axis and immune infiltration.
Organism Homo sapiens
Data Type Proteomic Data by Mass Spectrometry (MS)
Data Accessibility Controlled-access
BioProject PRJCA012513
Release Date 2022-12-09
Submitter Yao Zhao (zhaoyaohs@vip.sina.com)
Organization Huashan Hospital of Fudan University
Submission Date 2022-11-03
Request for this Data
2Files & Download

HTTP download speed may be slow. It is highly recommended that you download the dataset using a dedicated FTP tool (such as FileZilla Client).

File ID File Title Number/Samples File Type File Size File Suffix Download
OMIX002264-01 PitNET_021-030_phospho 10 Proteomic Data by Mass Spectrometry (MS) 8.26 GB zip Controlled
OMIX002264-02 PitNET_121-130_phospho 10 Proteomic Data by Mass Spectrometry (MS) 9.74 GB zip Controlled
OMIX002264-03 PitNET_161-170_phospho 10 Proteomic Data by Mass Spectrometry (MS) 9.5 GB zip Controlled
OMIX002264-04 PitNET_001-010_phospho 10 Proteomic Data by Mass Spectrometry (MS) 9.25 GB zip Controlled
OMIX002264-05 PitNET_011-020_phospho 10 Proteomic Data by Mass Spectrometry (MS) 8.75 GB zip Controlled
OMIX002264-06 PitNET_081-090_phospho 10 Proteomic Data by Mass Spectrometry (MS) 7.25 GB zip Controlled
OMIX002264-07 PitNET_141-150_phospho 10 Proteomic Data by Mass Spectrometry (MS) 11.31 GB zip Controlled
OMIX002264-08 PitNET_191-200_phospho 10 Proteomic Data by Mass Spectrometry (MS) 10.5 GB zip Controlled
OMIX002264-09 PitNET_091-100_phospho 10 Proteomic Data by Mass Spectrometry (MS) 11.06 GB zip Controlled
OMIX002264-10 PitNET_101-110_phospho 9 Proteomic Data by Mass Spectrometry (MS) 9.58 GB zip Controlled
OMIX002264-11 PitNET_181-190_phospho 10 Proteomic Data by Mass Spectrometry (MS) 8.73 GB zip Controlled
OMIX002264-12 PitNET_031-040_phospho 10 Proteomic Data by Mass Spectrometry (MS) 9.71 GB zip Controlled
OMIX002264-13 PitNET_171-180_phospho 10 Proteomic Data by Mass Spectrometry (MS) 11.03 GB zip Controlled
OMIX002264-14 PitNET_041-050_phospho 8 Proteomic Data by Mass Spectrometry (MS) 8.86 GB zip Controlled
OMIX002264-15 PitNET_111-120_phospho 10 Proteomic Data by Mass Spectrometry (MS) 7.7 GB zip Controlled
OMIX002264-16 PitNET_151-160_phospho 10 Proteomic Data by Mass Spectrometry (MS) 10.49 GB zip Controlled
OMIX002264-17 PitNET_051-060_phospho 9 Proteomic Data by Mass Spectrometry (MS) 9.17 GB zip Controlled
OMIX002264-18 PitNET_131-140_phospho 9 Proteomic Data by Mass Spectrometry (MS) 8.73 GB zip Controlled
OMIX002264-19 PitNET_071-080_phospho 10 Proteomic Data by Mass Spectrometry (MS) 10.58 GB zip Controlled
OMIX002264-20 PitNET_061-070_phospho 9 Proteomic Data by Mass Spectrometry (MS) 8.23 GB zip Controlled
3Relevant Publications
Paper Title Journal Name Publish Time Accession Citing Type

View All Released Data of OMIX