OMIX002265

1Summary
Title Proteomics datasets of Integrated Proteogenomic Characterization across Major Histological Types of Pituitary Neuroendocrine Tumors
Description Pituitary neuroendocrine tumor (PitNET) is one of the most common intracranial tumors. Here, we performed the largest integrative genomics, transcriptomics, proteomics, and phosphoproteomics analysis reported to date in a cohort of 200 PitNET patients. Genomics data indicated that GNAS copy number gain can serve as a reliable diagnostic marker for hyperproliferation of the PIT1 lineage. Proteomics-based classification of PitNETs identified 7 clusters, among which, tumors overexpressing epithelial-mesenchymal transition (EMT) markers clustered into a more invasive subgroup. Further analysis identified potential therapeutic targets, including CDK6, TWIST1, EGFR, and VEGFR2, for different clusters. Immune subtyping to explore the potential for application of immunotherapy in PitNET identified an association between alterations in the JAK1-STAT1-PDL1 axis and immune exhaustion and between changes in the JAK3-STAT6-FOS/JUN axis and immune infiltration.
Organism Homo sapiens
Data Type Proteomic Data by Mass Spectrometry (MS)
Data Accessibility Controlled-access
BioProject PRJCA012513
Release Date 2022-12-09
Submitter Yao Zhao (zhaoyaohs@vip.sina.com)
Organization Huashan Hospital of Fudan University
Submission Date 2022-11-03
Request for this Data
2Files & Download

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File ID File Title Number/Samples File Type File Size File Suffix Download
OMIX002265-01 PitNET_191-200_profiling 10 Proteomic Data by Mass Spectrometry (MS) 12.53 GB zip Controlled
OMIX002265-02 PitNET_181-190_profiling 10 Proteomic Data by Mass Spectrometry (MS) 12.45 GB zip Controlled
OMIX002265-03 PitNET_171-180_profiling 10 Proteomic Data by Mass Spectrometry (MS) 12.3 GB zip Controlled
OMIX002265-04 PitNET_151-160_profiling 10 Proteomic Data by Mass Spectrometry (MS) 12.48 GB zip Controlled
OMIX002265-05 PitNET_161-170_profiling 10 Proteomic Data by Mass Spectrometry (MS) 12.49 GB zip Controlled
OMIX002265-06 PitNET_131-140_profiling 10 Proteomic Data by Mass Spectrometry (MS) 12.41 GB zip Controlled
OMIX002265-07 PitNET_121-130_profiling 10 Proteomic Data by Mass Spectrometry (MS) 12.51 GB zip Controlled
OMIX002265-08 PitNET_141-150_profiling 10 Proteomic Data by Mass Spectrometry (MS) 12.72 GB zip Controlled
OMIX002265-09 PitNET_111-120_profiling 10 Proteomic Data by Mass Spectrometry (MS) 12.27 GB zip Controlled
OMIX002265-10 PitNET_101-110_profiling 10 Proteomic Data by Mass Spectrometry (MS) 12.5 GB zip Controlled
OMIX002265-11 PitNET_071-080_profiling 10 Proteomic Data by Mass Spectrometry (MS) 13.12 GB zip Controlled
OMIX002265-12 PitNET_051-060_profiling 10 Proteomic Data by Mass Spectrometry (MS) 12.75 GB zip Controlled
OMIX002265-13 PitNET_081-090_profiling 10 Proteomic Data by Mass Spectrometry (MS) 11.96 GB zip Controlled
OMIX002265-14 PitNET_061-070_profiling 10 Proteomic Data by Mass Spectrometry (MS) 11.71 GB zip Controlled
OMIX002265-15 PitNET_091-100_profiling 10 Proteomic Data by Mass Spectrometry (MS) 12.71 GB zip Controlled
OMIX002265-16 PitNET_031-040_profiling 10 Proteomic Data by Mass Spectrometry (MS) 12.49 GB zip Controlled
OMIX002265-17 PitNET_041-050_profiling 10 Proteomic Data by Mass Spectrometry (MS) 12.53 GB zip Controlled
OMIX002265-18 PitNET_021-030_profiling 10 Proteomic Data by Mass Spectrometry (MS) 12.17 GB zip Controlled
OMIX002265-19 PitNET_001-010_profiling 10 Proteomic Data by Mass Spectrometry (MS) 11.99 GB zip Controlled
OMIX002265-20 PitNET_011-020_profiling 10 Proteomic Data by Mass Spectrometry (MS) 11.96 GB zip Controlled
3Relevant Publications
Paper Title Journal Name Publish Time Accession Citing Type

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