| Title |
A novel molecular mechanism of vascular fibrosis in Takayasu arteritis: macrophage-derived GPNMB promoting adventitial fibroblast extracellular matrix production in the aorta |
| Description |
Macrophage derived GPNMB promotes AAFs ECM expression via the integrin avb1 receptor and AKT/ERK sign-fibrotic roleal pathway. Leflunomide might play an anti-fibrotic role in TAK by interfering with the macrophage-derived GPNMB/AAFs axis. |
| Organism |
Homo |
| Data Type |
Other Type of Clinical information |
| Data Accessibility |
Controlled-access |
| BioProject |
PRJCA010631 |
| Release Date |
2024-12-31 |
| Submitter |
Xiufang Kong (kongxiufang2007@163.com) |
| Organization |
Zhongshan Hospital, Fudan University |
| Submission Date |
2022-12-13 |