Next-generation sequencing-based MET focal amplification can predict treatment efficacy of MET inhibitors in lung cancer
| Title | Next-generation sequencing-based MET focal amplification can predict treatment efficacy of MET inhibitors in lung cancer |
|---|---|
| Description | Tissue samples from LC patients who underwent MET detection by FISH, NGS, and IHC tests at Shanghai Chest Hospital were retrospectively collected. MET focal amplification and polysomy by FISH were determined as MET/CEP7 ratio >=2, and < 2 with the average MET signals per cell >= 5, respectively. NGS-based MET focal amplification and polysomy were determined with in-house scripts (Burning Rock Biotech). Focal amplification and polysomy were defined as METamp-positive. IHC-based MET positive was determined with H-score >= 200. FISH was used as a reference |
| Organism | Homo sapiens |
| Data Type | Other Type of Genomic Data |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA013975 |
| Release Date | 2022-12-21 |
| Submitter | Yuchen Han (ychan@cmu.edu.cn) |
| Organization | Shanghai Chest Hospital, Shanghai Jiao Tong University |
| Submission Date | 2022-12-20 |
The data cannot be downloaded as it has not yet been registered in the Human Genetic Resource Management Platform of MOST.
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX002656-01 | MET amplification | 1 | Other Type of Genomic Data | 184.4 KB | rar | 0 | Unavailable |