Systematic analysis of lysine crotonylation in THP1 cells responding to MRSA infection
| Title | Systematic analysis of lysine crotonylation in THP1 cells responding to MRSA infection |
|---|---|
| Description | Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most commonly encountered bacteria found in healthcare clinics and has been ranked a priority 2 pathogen. Research is urgently needed to develop new therapeutic approaches to combat the pathogen. Variations in the pattern of protein posttranslational modifications (PTMs) of host cells affect physiological and pathological events, as well as therapeutic effectiveness. However, the role of crotonylation in MRSA-infected THP1 cells remains unknown. In this study, we found that crotonylation in THP1 cells was altered after MRSA infection. It was then confirmed that lysine crotonylation profiles of THP1 cells and bacteria were different; MRSA infection inhibited global lysine crotonylation (Kcro) modification but partially elevated Kcro of host proteins. |
| Organism | Cell fusing agent virus |
| Data Type | Other Type of Proteomic Data |
| Data Accessibility | Open-access |
| BioProject | PRJCA009045 |
| Release Date | 2023-01-29 |
| Submitter | Xia Yang (oceanyx@126.com) |
| Organization | State Key Laboratory of Trauma, Burn and Combined Injury |
| Submission Date | 2023-01-17 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX002820-01 | Systematic analysis of lysine crotonylation in THP1 cells responding to MRSA infection | 1 | Other Type of Proteomic Data | 261.1 KB | xlsx | 0 |