| Description |
Aiming at the Guangxi natural longevity cohort, which is characterized by health and longevity, the probability model of natural health and longevity was constructed with over 90 years old and over 100 years old as the key independent variables. The follow-up study of 8000 prospective cohort over 90 years old in Guangxi was carried out, and the whole-process health and longevity database and biological specimen bank were constructed. New gene variants related to aging health and longevity were obtained; Using big data analysis method and technology platform to develop a combination of omics technology based on double calibration of DNA methylation clock and mitochondrial clock, and population genetic design based on trio- method and proband method. To explore the relationship between the changes in the body (blood glucose, blood lipids, metabolic homeostasis, REDOX homeostasis, microecological balance)/external environment (lifestyle, psychology, nutrition) and related genetic factors in healthy aging. |