A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells
| Title | A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells |
|---|---|
| Description | Long noncoding RNAs (lncRNAs) have emerged as important components of gene regulatory network in embryonic stem cells (ESCs). However, the function and molecular mechanism of lncRNAs are still largely unknown. Here we identifies Trincr1 (TRIM71 interacting long noncoding RNA 1) lncRNA that regulates the FGF/ERK signaling and self-renewal of ESCs. Trincr1 is exported by THOC complex to cytoplasm where it binds and represses TRIM71, leading to the downregulation of SHCBP1 protein. Knocking out Trincr1 leads to the upregulation of phosphorylated ERK and ERK pathway target genes and the decrease of ESC self-renewal, while knocking down Trim71 completely rescues the defects of Trincr1 knockout. Furthermore, ectopic expression of Trincr1 represses FGF/ERK signaling and the self-renewal of neural progenitor cells (NPCs). Together, this study highlights lncRNA as an important player in cell signaling network to coordinate cell fate specification. |
| Organism | Mus musculus |
| Data Type | Proteomic Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA004978 |
| Release Date | 2023-02-21 |
| Submitter | Yangming Wang (yangming.wang@pku.edu.cn) |
| Organization | Peking University |
| Submission Date | 2023-02-20 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX003028-01 | 16-375_LYP1202_case-2 | 1 | Proteomic Data by Mass Spectrometry (MS) | 156.44 MB | raw | 0 | |
| OMIX003028-02 | 16-093_LYP0329_case | 1 | Proteomic Data by Mass Spectrometry (MS) | 165.95 MB | raw | 0 | |
| OMIX003028-03 | 16-375_LYP1202_control-1 | 1 | Proteomic Data by Mass Spectrometry (MS) | 168.26 MB | raw | 0 | |
| OMIX003028-04 | 16-093_LYP0329_control | 1 | Proteomic Data by Mass Spectrometry (MS) | 158.05 MB | raw | 0 | |
| OMIX003028-05 | 16-375_LYP1202_control-2 | 1 | Proteomic Data by Mass Spectrometry (MS) | 168.13 MB | raw | 0 | |
| OMIX003028-06 | 16-375_LYP1202_case-1 | 1 | Proteomic Data by Mass Spectrometry (MS) | 180.57 MB | raw | 0 |