the Structure and function of brain cognitive neurotransmitter receptor signaling complex
| Title | the Structure and function of brain cognitive neurotransmitter receptor signaling complex |
|---|---|
| Description | Through the completion of this project, we will further clarify the binding and recognition mechanism of 5 HT and dopamine receptors and small molecule ligands, as well as the mechanism of d ownstream signal transduction proteins. It also provides the structural basis for the research and development of drugs targeting development of drugs targeting 5--HT and dopamine receptors, which has very significant theoretical HT and dopamine receptors, which has very significant theoretical guiding significance and practical application value.guiding significance and practical application value. |
| Organism | Homo sapiens |
| Data Type | Other Type of Image Data |
| Data Accessibility | Open-access |
| BioProject | PRJCA016774 |
| Release Date | 2023-05-07 |
| Submitter | Man Wang (wangman8538@simm.ac.cn) |
| Organization | Shanghai Institute of Materia Medica CAS |
| Submission Date | 2023-05-06 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX003949-01 | Structures of the human dopamine D3 receptor-Gi complexes | 4 | Other Type of Image Data | 43.5 MB | zip | 0 | |
| OMIX003949-02 | Structural insights into the human D1 and D2 dopamine receptor signaling complexes | 2 | Other Type of Image Data | 25.4 MB | zip | 0 | |
| OMIX003949-03 | Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor | 2 | Other Type of Image Data | 19.5 MB | zip | 0 | |
| OMIX003949-04 | Structural insights into the lipid and ligand regulation of serotonin receptors | 10 | Other Type of Image Data | 111.7 MB | zip | 0 | |
| OMIX003949-05 | Structural basis for recognition of anti migraine drug lasmiditan by the serotonin receptor 5HT1FG protein complex | 2 | Other Type of Image Data | 26.8 MB | zip | 0 | |
| OMIX003949-06 | Structural insights into the ligand binding and Gi coupling of serotonin receptor 5HT5A | 2 | Other Type of Image Data | 28.9 MB | zip | 0 | |
| OMIX003949-07 | GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors | 7 | Other Type of Image Data | 81.1 MB | zip | 0 | |
| OMIX003949-08 | Molecular recognition of morphine and fentanyl by the human m-opioid receptor | 2 | Other Type of Image Data | 36.0 MB | zip | 0 |