Deciphering the Cellular and Molecular Mechanisms of Intrauterine Adhesion through Single-Cell RNA-Sequencing
| Title | Deciphering the Cellular and Molecular Mechanisms of Intrauterine Adhesion through Single-Cell RNA-Sequencing |
|---|---|
| Description | Intrauterine adhesion (IUA), is a common acquired endometrial disease, which is mainly secondary to endometrial injury, resulting in severe implications for women's reproductive health, causing years of potential infertility or recurrent pregnancy loss. However, the underlying molecular and cellular mechanisms that drive this pathophysiology remain largely unknown, thereby hindering early diagnosis and treatment. Here, we aimed to address this knowledge gap by profiling integrated single-cell transcriptomes of over 39,000 individual cells derived from both IUA and normal endometrial tissues. We identified distinct changes in cell type-specific and molecular signatures associated with IUA, including the inflammatory activation in immune cells, diffuse damage in epithelial subpopulations and the deposition of collagen secreted by fibroblasts subpopulations. |
| Organism | Homo sapiens |
| Data Type | Expression Profiling by NGS |
| Data Accessibility | Open-access |
| BioProject | PRJCA017474 |
| Release Date | 2024-08-19 |
| Submitter | siyu xia (syxbestmayer@whu.edu.cn) |
| Organization | Jinan University |
| Submission Date | 2023-06-04 |
The data cannot be downloaded as it has not yet been registered in the Human Genetic Resource Management Platform of MOST.
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX004273-01 | ZL08301 | 1 | Expression Profiling by NGS | 325.62 KB | tsv | 0 | Unavailable |