Proteomic analyses of smear-positive/negative tuberculosis patients uncover differential antigen-presenting cell activation and lipid metabolism
| Title | Proteomic analyses of smear-positive/negative tuberculosis patients uncover differential antigen-presenting cell activation and lipid metabolism |
|---|---|
| Description | Smear-Negative Pulmonary Tuberculosis (SNPT) and Smear-Positive Pulmonary Tuberculosis (SPPT) are two common types of pulmonary tuberculosis characterized by distinct bacterial loads. To date, the precise molecular mechanisms underlying the differences between SNPT and SPPT patients remain unclear and no studies have yet employed proteomic analysis to unravel the differential molecular mechanisms between SNPT and SPPT. Our findings comprehensively revealed differential immune and metabolic mechanisms/microenvironments between SPPT and SNPT plasma samples, and reveal the critical role of antigen-presenting cells in SNPT for clearing up the majority of Mtb in bodies.Our study provides valuable insights into the differential molecular mechanisms underlying SNPT and SPPT, reveals the critical role of antigen-presenting cell activation in SNPT for effectively clearing the majority of Mtb in bodies, and shows the possibility of APC activation as a novel TB treatment strategy. |
| Organism | Homo sapiens |
| Data Type | Proteomic Data by Mass Spectrometry (MS) |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA017696 |
| Release Date | 2023-11-13 |
| Submitter | Fei Chen (chenfei@big.ac.cn) |
| Organization | Beijing Institute of Genomics, Chinese Academy of Sciences |
| Submission Date | 2023-06-14 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX004336-01 | TMT-labeled quantitative proteomic data | 14 | Proteomic Data by Mass Spectrometry (MS) | 2.9 GB | tar | 0 | Controlled |
| OMIX004336-02 | Targeted lipidomic data | 62 | Proteomic Data by Mass Spectrometry (MS) | 15.27 MB | tar | 0 | Controlled |
| OMIX004336-03 | PRM targeted quantitative proteomic data | 100 | Proteomic Data by Mass Spectrometry (MS) | 64.77 GB | tar | 0 | Controlled |