BET inhibitor in combination with Bacillus Calmette-Guerin enhances antitumor efficacy and orchestrates T cell reprogramming for melanoma
| Title | BET inhibitor in combination with Bacillus Calmette-Guerin enhances antitumor efficacy and orchestrates T cell reprogramming for melanoma |
|---|---|
| Description | Immunotherapy has shown remarkable benefits in treating melanoma, yet existing approaches have achieved limited overall responses. Here, we showed that a combination of bromodomain and extra-terminal protein family inhibitor, NHWD-870, and Bacillus Calmette-Guerin (BCG) was a promising therapeutic strategy for melanomas. Single cell transcriptome analyses and functional experiments showed that combination therapy significantly inhibited tumor growth by reprogramming T cells towards an immune-activated state, enhancing their cytotoxicity, preventing their exhaustion, and increasing the recruitment of them into the tumor microenvironment. |
| Organism | Mus musculus |
| Data Type | Biomarker Data |
| Data Accessibility | Open-access |
| BioProject | PRJCA020016 |
| Release Date | 2023-09-22 |
| Submitter | Mingzhu Yin (yinmingzhu2008@126.com) |
| Organization | Chongqing University Three Gorges Hospital |
| Submission Date | 2023-09-22 |
HTTP download speed may be slow. It is highly recommended that you download the dataset using a dedicated FTP tool (such as FileZilla Client).
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX004978-01 | NHWD_870 mouse | 3 | Biomarker Data | 4.51 GB | rds | 0 |