Roseburia intestinalis relieves intrahepatic cholestasis of pregnancy through bile acid/FXR-FGF15 in rats
| Title | Roseburia intestinalis relieves intrahepatic cholestasis of pregnancy through bile acid/FXR-FGF15 in rats |
|---|---|
| Description | In conclusion, our research has identified R.I as a key player in ICP. We have demonstrated that R.I improved phenotypes associated with ICP through the bile acid/FXR-FGF15 signaling pathway. These findings suggested that R.I may be a promising target for the treatment of ICP. Our research highlights the important role of intestinal flora in the pathogenesis of ICP and provides a novel approach for its treatment. |
| Organism | Rattus |
| Data Type | Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA020045 |
| Release Date | 2023-12-29 |
| Submitter | Hanxiang Sun (shx10272023@163.com) |
| Organization | Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University |
| Submission Date | 2023-09-22 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX004988-01 | DZLM2023030920 | 43 | Metabolome Data by Mass Spectrometry (MS) | 6.8 MB | zip | 0 |