| Title |
Roseburia intestinalis relieves intrahepatic cholestasis of pregnancy through bile acid/FXR-FGF15 in rats |
| Description |
In conclusion, our research has identified R.I as a key player in ICP. We have demonstrated that R.I improved phenotypes associated with ICP through the bile acid/FXR-FGF15 signaling pathway. These findings suggested that R.I may be a promising target for the treatment of ICP. Our research highlights the important role of intestinal flora in the pathogenesis of ICP and provides a novel approach for its treatment. |
| Organism |
Rattus |
| Data Type |
Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility |
Open-access |
| BioProject |
PRJCA020045 |
| Release Date |
2023-12-29 |
| Submitter |
Hanxiang Sun (shx10272023@163.com) |
| Organization |
Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University |
| Submission Date |
2023-09-22 |