Integrated Metabonomics, 16S rDNA and mRNA sequencing to Reveal the Action Mechanism Effect of Shaoyao Decoction on Ulcerative Colitis
| Title | Integrated Metabonomics, 16S rDNA and mRNA sequencing to Reveal the Action Mechanism Effect of Shaoyao Decoction on Ulcerative Colitis |
|---|---|
| Description | Traditional Chinese medicine (TCM), had shown significantly curative effect in treating ulcerative colitis (UC) in the clinic with unclear mechanism. Therefore, we performed this study to explore the pharmacological mechanism by using 16S rDNA, mRNA sequencing and targeted metabolomics. In a mouse model of dextran sulfate sodium (DSS)-induced colitis, SYD significantly ameliorated bloody stool, tissue damage, inflammation, dysbiosis of the intestinal flora, and aberrant gene expression. Moreover, SYD may be involved in modulating the local inflammatory response in the intestine via the intestinal flora and its metabolites, as evidenced by the alpha indices, the beta distances, and the specific genera of intestinal bacteria relative abundance, as well as Short-chain fatty acids alterations in serum and faecal. |
| Organism | Mus |
| Data Type | Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA021238 |
| Release Date | 2024-01-01 |
| Submitter | yini li (lyn@bucm.edu.cn) |
| Organization | Beijing University of Chinese Medicine |
| Submission Date | 2023-11-13 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX005234-01 | SCFAs - mouse faeces | 30 | Metabolome Data by Mass Spectrometry (MS) | 1.2 MB | tar | 0 |