Single-cell profiling reveals distinct immune hallmarks in untreated primary colorectal and liver metastasis cancers
| Title | Single-cell profiling reveals distinct immune hallmarks in untreated primary colorectal and liver metastasis cancers |
|---|---|
| Description | 11 major cell types are identified, high heterogeneity of cell distribution among different locations is observed. By comparison between liver metastatic and primary data, we reveal several new features in liver metastatic tumors including CXCL13+ CD4 T cells and regulatory CD4 T cells enriched, exhausted CD8+ T cells (Tex) decreased, SPP1+ macrophage increased, IGFBP7+ CAFs from metastatic tumors cells and the specific activation of the linoleic acid metabolism pathway. Besides, tumor cells contribute to four distinct biological modules, encompassing apoptosis, epithelial-mesenchymal transition (EMT), the cell cycle, and immune processes. |
| Organism | Homo sapiens |
| Data Type | Other Type of Genomic Data |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA022675 |
| Release Date | 2024-01-09 |
| Submitter | xishan wang (wxshan1208@126.com) |
| Organization | Department of Colorectal Surgery, National Cancer Center |
| Submission Date | 2024-01-08 |
The data cannot be downloaded as it has not yet been registered in the Human Genetic Resource Management Platform of MOST.
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX005611-01 | Single-cell profiling reveals distinct immune hallmarks in untreated primary colorectal and liver metastasis cancers | 11 | Other Type of Genomic Data | 585.54 MB | zip | 0 | Unavailable |