Genetic admixture and evolutionary history of Han Chinese in the Shandong Peninsula inferred from integrative modern and ancient genomic resources
| Title | Genetic admixture and evolutionary history of Han Chinese in the Shandong Peninsula inferred from integrative modern and ancient genomic resources |
|---|---|
| Description | We reported one integrative ancient and modern genomic resource to inspect the fine-scale population admixture scenarios and adaptative evolutionary features. Demographical history reconstruction and hierarchical clustering patterns suggested that northern Han from the Shandong peninsula had long-term genetic continuity and mobility in the lower YRB since the middle Neolithic period. The reconstructed allele frequency trajectories and haplotype network identified two highly differentiated genes related to axillary odor (ABCC11) and bilirubin metabolism (SLC10A1). Our work underscored the importance of evolutionary views in understanding the spatiotemporal distribution patterns of genetic risk variants and provided one paradigm for combining ancient genomes in the population genomic medicine era. |
| Organism | Homo sapiens |
| Data Type | Other Type of Genomic Data |
| Data Accessibility | Open-access |
| BioProject | PRJCA023355 |
| Release Date | 2024-06-06 |
| Submitter | Guanglin He (Guanglinhescu@163.com) |
| Organization | Institute of Rare Diseases, West China Hospital of Sichuan University |
| Submission Date | 2024-01-31 |
The data cannot be downloaded as it has not yet been registered in the Human Genetic Resource Management Platform of MOST.
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX005781-02 | omix | 2 | Other Type of Genomic Data | 4.3 MB | rar | 0 | Unavailable |