Phosphorylation of AGO2 by TBK1 Promotes the Formation of Oncogenic miRISC in NSCLC
| Title | Phosphorylation of AGO2 by TBK1 Promotes the Formation of Oncogenic miRISC in NSCLC |
|---|---|
| Description | To explore the global impact of pS417-AGO2 on the miRNA pathway, we performed high-through sequencings including AGO2-RIP-Seq and RNA-Seq on the NSCLC cell line H1299-shAGO2+Flag-AGO2(WT) and H1299-shAGO2+Flag-AGO2(S417A). The results showed that pS417-AGO2 promotes the loadings of high-abundance oncogenic miRNAs into AGO2 in NSCLC cells. |
| Organism | Homo sapiens |
| Data Type | Non-coding RNA Profiling by NGS |
| Data Accessibility | Open-access |
| BioProject | PRJCA024159 |
| Release Date | 2024-05-01 |
| Submitter | jianxiu Yu (jianxiu.yu@gmail.com) |
| Organization | Shanghai Jiao Tong University School of Medicine |
| Submission Date | 2024-03-18 |
The data cannot be downloaded as it has not yet been registered in the Human Genetic Resource Management Platform of MOST.
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX006016-01 | AGO2-RIP-seq | 2 | Non-coding RNA Profiling by NGS | 58.8 KB | xlsx | 0 | Unavailable |
| OMIX006016-02 | RNA-seq | 2 | Non-coding RNA Profiling by NGS | 5.3 MB | xlsx | 0 | Unavailable |