Sini San ameliorates hepatocyte apoptosis through regulating Intestinal Flora and SCFAs in CCL4-induced hepatic fibrosis mice
| Title | Sini San ameliorates hepatocyte apoptosis through regulating Intestinal Flora and SCFAs in CCL4-induced hepatic fibrosis mice |
|---|---|
| Description | The UPLC-ESI-MS/MS analytical method was used for the qualitative and quantitative detection of the target metabolites, and the specific analytical conditions and analytical methods were as follows: The chromatographic column was ACQUITY UPLC BRHC18 (100*2.1mm, 1.7um), Waters; the high performance liquid chromatograph was Nexera UHPLC LC-30A, Shimadzu, Japan; Chromatographic conditions: Injection volume: 5 μL; Flow rate: 0.35 mL/min; Gradient Elution Procedures (GEP): 0 min A/B (90:10, V/V), 1 min A/B (90:10, V/V), 2 min A/B (75:25, V/V), 6 min A/B (65:35, V/V), 6.5 min A/B (5:95, V/V). 7.8 min A/B (5:95, V/V), 7.81 min A/B (90:10, V/V), 8.5 min A/B (90:10, V/V).A highly sensitive mass spectrometer AB Sciex Qtrap 5500, AB Sciex was used. Mass spectrometry conditions: Curtain gas: 35 (psi); Collision-activated dissociation (CAD) parameters: medium; Positive ion spray voltage: 5500V; negative ion spray voltage: -4500V; Ion source temperature: 450°C; Column temperature: 40°C; |
| Organism | Mus musculus |
| Data Type | Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA024508 |
| Release Date | 2024-03-21 |
| Submitter | qiong wu (2638794343@qq.com) |
| Organization | First Affiliated Hospital of Anhui Medical University |
| Submission Date | 2024-03-20 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX006041-01 | CCL4-induced mice | 8 | Metabolome Data by Mass Spectrometry (MS) | 4.68 MB | zip | 0 |