Foodborne carbon dot-induced gut microbiota dysbiosis lead to reproductive toxicity in male mice
| Title | Foodborne carbon dot-induced gut microbiota dysbiosis lead to reproductive toxicity in male mice |
|---|---|
| Description | Metabolites were extracted from feces or serum by incorporating 20 μl of a separation buffer consisting of methanol, acetonitrile, and water at a 2:2:1 ratio into 1 mg of cervical secretions. To evaluate the stability throughout the experimental process, a quality control (QC) sample was prepared by aggregating 10 μl of the isolate mixture from each specimen[47]. Subsequently, 2 μl of the isolate from each sample was utilized for the detection of metabolite signals using liquid chromatography (LC) and mass spectrometry (MS) with an ACQUITY UPLC I-Class plus system (Waters). Qualitative analysis of the raw data was conducted using Progenesis QI v2.3 metabolomics processing software, adopting parameters of 5 ppm for precursor tolerance, 10 ppm for product tolerance, and a 5% threshold for product ions (Nonlinear Dynamics, Newcastle, UK). |
| Organism | Mus musculus |
| Data Type | Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA024662 |
| Release Date | 2024-03-30 |
| Submitter | Guihua Liu (liuguihua@mail.sysu.edu.cn) |
| Organization | The Sixth Affiliated Hospital, Sun Yat-sen University |
| Submission Date | 2024-03-28 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX006104-01 | DZLM2023122855-b1-001 | 7 | Metabolome Data by Mass Spectrometry (MS) | 10.01 GB | tar | 0 | |
| OMIX006104-02 | DZLM2023122855-b1-002 | 7 | Metabolome Data by Mass Spectrometry (MS) | 5.29 GB | tar | 0 |