First-line Penpulimab (anti-PD1 antibody) and Anlotinib (angiogenesis inhibitor) with Nab-paclitaxel/Gemcitabine (PAAG) in Metastatic Pancreatic Cancer: A Prospective, Multicentre, Biomolecular Exploratory, Phase II Trial
| Title | First-line Penpulimab (anti-PD1 antibody) and Anlotinib (angiogenesis inhibitor) with Nab-paclitaxel/Gemcitabine (PAAG) in Metastatic Pancreatic Cancer: A Prospective, Multicentre, Biomolecular Exploratory, Phase II Trial |
|---|---|
| Description | Pancreatic cancer (PC), a common malignant tumor of the digestive system, has shown a gradual increase in incidence and mortality worldwide. Both the CISPD3 study and the PRINCE study suggest that the combination of chemotherapy and ICI in PC can improve the ORR, reaching approximately 50%. The interaction between the activation of angiogenic signalling pathways and the suppression of tumor immunity has been validated. For instance, patients with advanced intrahepatic cholangiocarcinoma (ICC) received a combination of toripalimab, lenvatinib, and gemcitabine plus oxaliplatin (GEMOX), reaching a breakthrough ORR of 80%. Considering the similar tumor microenvironment of gastrointestinal tumors, it is reasonable to combine anti-PD-1 therapy with antiangiogenic drugs and chemotherapy in mPC. Herein, we report the clinical and translational results of a prospective, multicentre, single-arm, phase 2 trial for the first-line treatment of patients with mPC who received PAAG. |
| Organism | Homo sapiens |
| Data Type | Genetic Biomarkers |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA025384 |
| Release Date | 2024-04-19 |
| Submitter | Juan Du (juandunjglyy@163.com) |
| Organization | Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School |
| Submission Date | 2024-04-18 |
The data cannot be downloaded as it has not yet been registered in the Human Genetic Resource Management Platform of MOST.
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX006277-01 | PAAG-variant | 1 | Genetic Biomarkers | 53.1 KB | xlsx | 0 | Unavailable |