Novel regulators identified by quantitative phosphoproteomics analysis during ticagrelor-induced inhibition of platelet
| Title | Novel regulators identified by quantitative phosphoproteomics analysis during ticagrelor-induced inhibition of platelet |
|---|---|
| Description | Ticagrelor is frequently applied in antiplatelet therapy. However, its application is associated with increased risk of bleeding complications. To study its antiplatelet mechanisms, mass-spectrometry-based phosphoproteomic technique was applied to obtain phosphorylation spectra in platelets. Platelets underwent activation with 20 μM ADP for 30 seconds followed by inhibition with 2 nM ticagrelor for another 30 seconds. We successfully quantified 2285 phosphopeptides with high confidence in 1189 phosphoprotein. The data file contains the quantification of the 2285 phosphopeptides. |
| Organism | Homo |
| Data Type | Other Type of Proteomic Data |
| Data Accessibility | Open-access |
| BioProject | PRJCA025725 |
| Release Date | 2024-04-30 |
| Submitter | Zhe Xu (xuzh@ncrcnd.org.cn) |
| Organization | Beijing Tiantan Hospital, Capital Medical University |
| Submission Date | 2024-04-29 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX006344-01 | data.xlsx | 3 | Other Type of Proteomic Data | 334.2 KB | xlsx | 0 |