Proteomic analysis of small intestinal epithelial cells after E. coli infection
| Title | Proteomic analysis of small intestinal epithelial cells after E. coli infection |
|---|---|
| Description | Macaca mulatta (Mm) is an ideal non-human primate model for biomedical research. However, extensive captive breeding makes Mm frequently challenged by infectious intestinal diseases caused by pathogenic Escherichia coli (E. coli). We found that intestinal iron enrichment caused by pathogenic E. coli is strongly associated with infectious diarrhea in Mm due to E. coli and host interactions. Iron overload after infection makes intestinal epithelial cells more susceptible to pathogenic E. coli, which in turn induces ferroptosis and pyroptosis of intestinal epithelial cells, resulting in intestinal injury. These findings will lead to a better understanding of the pathogenesis of infectious diarrhea in non-human primates. |
| Organism | Macaca mulatta |
| Data Type | Proteomic Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA026881 |
| Release Date | 2024-06-13 |
| Submitter | hao Wang (wanghaoxu0117@163.com) |
| Organization | Yunnan Agricultural University |
| Submission Date | 2024-06-11 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX006662-01 | Rawdata_4.tar.gz | 4 | Proteomic Data by Mass Spectrometry (MS) | 3.16 GB | tar.gz | 0 | |
| OMIX006662-02 | Rawdata_1.tar.gz | 4 | Proteomic Data by Mass Spectrometry (MS) | 3.42 GB | tar.gz | 0 | |
| OMIX006662-03 | Rawdata_2.tar.gz | 4 | Proteomic Data by Mass Spectrometry (MS) | 3.2 GB | tar.gz | 0 | |
| OMIX006662-04 | Rawdata_3.tar.gz | 4 | Proteomic Data by Mass Spectrometry (MS) | 3.08 GB | tar.gz | 0 | |
| OMIX006662-05 | Rawdata_5.tar.gz | 4 | Proteomic Data by Mass Spectrometry (MS) | 3.23 GB | tar.gz | 0 |