Age-related dysregulation of B cells in acute respiratory distress syndrome
| Title | Age-related dysregulation of B cells in acute respiratory distress syndrome |
|---|---|
| Description | The role of B cells in distinguishing the outcomes of acute respiratory distress syndrome (ARDS) in children and adults remains unclear. We studied the transcriptomic characteristics of peripheral blood B cell alterations in children and adults with ARDS using single-cell RNA and B-cell receptor repertoire analysis. During the acute phase, adults exhibited higher neutrophil counts and lower B cell levels than children. Upregulated interferon-γ and interferon-α contributed to aberrant nuclear factor kappa B and Janus kinase/signal transducers and activators of transcription activation, resulting in apoptosis and pro-inflammation in plasma cells of adults and children with ARDS, respectively. Autoimmune patterns and diminished hyperexpanded clonotypes in plasma cells were similar in fatal cases of ARDS in adults and children. These findings elucidate B cell maturation, activation, and immunoglobulin patterns in ARDS, providing a foundation for prognostic assessment and B cell-targeted therapies. |
| Organism | Homo sapiens |
| Data Type | Other Type of Genomic Data |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA029271 |
| Release Date | 2024-08-22 |
| Submitter | Lixin Xie (1937291638@qq.com) |
| Organization | Chinese PLA General Hospital |
| Submission Date | 2024-08-21 |
The data cannot be downloaded as it has not yet been registered in the Human Genetic Resource Management Platform of MOST.
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX007171-01 | Adult control; Patient ID: 14; BCR | 1 | Other Type of Genomic Data | 38.5 KB | tar | 0 | Unavailable |
| OMIX007171-02 | AARDS; Patient ID: 19; Time point:T1; BCR | 1 | Other Type of Genomic Data | 190.5 KB | tar | 0 | Unavailable |
| OMIX007171-03 | Adult control; Patient ID: 16; scRNA-seq | 1 | Other Type of Genomic Data | 6.09 MB | tar | 0 | Unavailable |
| OMIX007171-04 | Child control; Patient ID: 3; scRNA-seq | 1 | Other Type of Genomic Data | 31.85 MB | tar | 0 | Unavailable |
| OMIX007171-05 | Adult control; Patient ID: 15; BCR | 1 | Other Type of Genomic Data | 141 KB | tar | 0 | Unavailable |
| OMIX007171-06 | Adult control; Patient ID: 13; BCR | 1 | Other Type of Genomic Data | 601 KB | tar | 0 | Unavailable |
| OMIX007171-07 | Child control; Patient ID: 5; BCR | 1 | Other Type of Genomic Data | 286.5 KB | tar | 0 | Unavailable |
| OMIX007171-08 | PARDS; Patient ID: 12; Time point:T2; BCR | 1 | Other Type of Genomic Data | 296.5 KB | tar | 0 | Unavailable |
| OMIX007171-09 | AARDS; Patient ID: 19; Time point:T1; scRNA-seq | 1 | Other Type of Genomic Data | 11 MB | tar | 0 | Unavailable |
| OMIX007171-10 | PARDS; Patient ID: 8; Time point:T2; BCR | 1 | Other Type of Genomic Data | 2.69 MB | tar | 0 | Unavailable |
| OMIX007171-11 | PARDS; Patient ID: 9; Time point:T1; scRNA-seq | 1 | Other Type of Genomic Data | 96.93 MB | tar | 0 | Unavailable |
| OMIX007171-12 | PARDS; Patient ID: 11; Time point:T1; scRNA-seq | 1 | Other Type of Genomic Data | 8.08 MB | tar | 0 | Unavailable |
| OMIX007171-13 | AARDS; Patient ID: 23; Time point:T2; BCR | 1 | Other Type of Genomic Data | 190.5 KB | tar | 0 | Unavailable |
| OMIX007171-14 | PARDS; Patient ID: 8; Time point:T2; scRNA-seq | 1 | Other Type of Genomic Data | 24.85 MB | tar | 0 | Unavailable |
| OMIX007171-15 | PARDS; Patient ID: 12; Time point:T1; BCR | 1 | Other Type of Genomic Data | 449 KB | tar | 0 | Unavailable |
| OMIX007171-16 | AARDS; Patient ID: 18; Time point:T1; scRNA-seq | 1 | Other Type of Genomic Data | 36.83 MB | tar | 0 | Unavailable |
| OMIX007171-17 | Child control; Patient ID: 5; scRNA-seq | 1 | Other Type of Genomic Data | 26.8 MB | tar | 0 | Unavailable |
| OMIX007171-18 | Adult control; Patient ID: 15; scRNA-seq | 1 | Other Type of Genomic Data | 17.05 MB | tar | 0 | Unavailable |
| OMIX007171-19 | Child control; Patient ID: 3; BCR | 1 | Other Type of Genomic Data | 160 KB | tar | 0 | Unavailable |
| OMIX007171-20 | Adult control; Patient ID: 13; scRNA-seq | 1 | Other Type of Genomic Data | 61.44 MB | tar | 0 | Unavailable |
| OMIX007171-21 | PARDS; Patient ID: 9; Time point:T2; scRNA-seq | 1 | Other Type of Genomic Data | 84.3 MB | tar | 0 | Unavailable |
| OMIX007171-22 | AARDS; Patient ID: 22; Time point:T1; BCR | 1 | Other Type of Genomic Data | 38.5 KB | tar | 0 | Unavailable |
| OMIX007171-23 | PARDS; Patient ID: 10; Time point:T2; BCR | 1 | Other Type of Genomic Data | 447.5 KB | tar | 0 | Unavailable |
| OMIX007171-24 | PARDS; Patient ID: 7; Time point:T2; BCR | 1 | Other Type of Genomic Data | 454 KB | tar | 0 | Unavailable |
| OMIX007171-25 | Adult control; Patient ID: 14; scRNA-seq | 1 | Other Type of Genomic Data | 4.41 MB | tar | 0 | Unavailable |
| OMIX007171-26 | PARDS; Patient ID: 7; Time point:T1; scRNA-seq | 1 | Other Type of Genomic Data | 17.2 MB | tar | 0 | Unavailable |
| OMIX007171-27 | PARDS; Patient ID: 10; Time point:T1; scRNA-seq | 1 | Other Type of Genomic Data | 3.98 MB | tar | 0 | Unavailable |
| OMIX007171-28 | PARDS; Patient ID: 9; Time point:T1; BCR | 1 | Other Type of Genomic Data | 1.14 MB | tar | 0 | Unavailable |
| OMIX007171-29 | Child control; Patient ID: 6; BCR | 1 | Other Type of Genomic Data | 961 KB | tar | 0 | Unavailable |
| OMIX007171-30 | PARDS; Patient ID: 10; Time point:T1; BCR | 1 | Other Type of Genomic Data | 49 KB | tar | 0 | Unavailable |
| OMIX007171-31 | PARDS; Patient ID: 7; Time point:T1; BCR | 1 | Other Type of Genomic Data | 331.5 KB | tar | 0 | Unavailable |
| OMIX007171-32 | AARDS; Patient ID: 21; Time point:T1; BCR | 1 | Other Type of Genomic Data | 49 KB | tar | 0 | Unavailable |
| OMIX007171-33 | Child control; Patient ID: 4;; scRNA-seq | 1 | Other Type of Genomic Data | 8.27 MB | tar | 0 | Unavailable |
| OMIX007171-34 | AARDS; Patient ID: 20; Time point:T1; BCR | 1 | Other Type of Genomic Data | 61.5 KB | tar | 0 | Unavailable |
| OMIX007171-35 | Child control; Patient ID: 1; BCR | 1 | Other Type of Genomic Data | 1.19 MB | tar | 0 | Unavailable |
| OMIX007171-36 | Child control; Patient ID: 2; scRNA-seq | 1 | Other Type of Genomic Data | 77.15 MB | tar | 0 | Unavailable |
| OMIX007171-37 | Child control; Patient ID: 2; BCR | 1 | Other Type of Genomic Data | 611.5 KB | tar | 0 | Unavailable |
| OMIX007171-38 | AARDS; Patient ID: 23; Time point:T2; scRNA-seq | 1 | Other Type of Genomic Data | 84.22 MB | tar | 0 | Unavailable |
| OMIX007171-39 | PARDS; Patient ID: 8; Time point:T1; scRNA-seq | 1 | Other Type of Genomic Data | 30.66 MB | tar | 0 | Unavailable |
| OMIX007171-40 | AARDS; Patient ID: 18; Time point:T1; BCR | 1 | Other Type of Genomic Data | 395.5 KB | tar | 0 | Unavailable |
| OMIX007171-41 | PARDS; Patient ID: 11; Time point:T2; scRNA-seq | 1 | Other Type of Genomic Data | 14.31 MB | tar | 0 | Unavailable |
| OMIX007171-42 | AARDS; Patient ID: 20; Time point:T1; scRNA-seq | 1 | Other Type of Genomic Data | 27.02 MB | tar | 0 | Unavailable |
| OMIX007171-43 | Child control; Patient ID: 4;; BCR | 1 | Other Type of Genomic Data | 79.5 KB | tar | 0 | Unavailable |
| OMIX007171-44 | PARDS; Patient ID: 12; Time point:T2; scRNA-seq | 1 | Other Type of Genomic Data | 86.06 MB | tar | 0 | Unavailable |
| OMIX007171-45 | Child control; Patient ID: 1; scRNA-seq | 1 | Other Type of Genomic Data | 81.88 MB | tar | 0 | Unavailable |
| OMIX007171-46 | PARDS; Patient ID: 11; Time point:T1; BCR | 1 | Other Type of Genomic Data | 9.56 MB | tar | 0 | Unavailable |
| OMIX007171-47 | PARDS; Patient ID: 10; Time point:T2; scRNA-seq | 1 | Other Type of Genomic Data | 32.2 MB | tar | 0 | Unavailable |
| OMIX007171-48 | Child control; Patient ID: 6; scRNA-seq | 1 | Other Type of Genomic Data | 90.58 MB | tar | 0 | Unavailable |
| OMIX007171-49 | AARDS; Patient ID: 21; Time point:T1; scRNA-seq | 1 | Other Type of Genomic Data | 9.25 MB | tar | 0 | Unavailable |
| OMIX007171-50 | Adult control; Patient ID: 16; BCR | 1 | Other Type of Genomic Data | 176.5 KB | tar | 0 | Unavailable |
| OMIX007171-51 | AARDS; Patient ID: 22; Time point:T1; scRNA-seq | 1 | Other Type of Genomic Data | 46.96 MB | tar | 0 | Unavailable |
| OMIX007171-52 | PARDS; Patient ID: 9; Time point:T2; BCR | 1 | Other Type of Genomic Data | 2.88 MB | tar | 0 | Unavailable |
| OMIX007171-53 | Adult control; Patient ID: 17; BCR | 1 | Other Type of Genomic Data | 551.5 KB | tar | 0 | Unavailable |
| OMIX007171-54 | PARDS; Patient ID: 11; Time point:T2; BCR | 1 | Other Type of Genomic Data | 51.5 KB | tar | 0 | Unavailable |
| OMIX007171-55 | PARDS; Patient ID: 7; Time point:T2; scRNA-seq | 1 | Other Type of Genomic Data | 22.47 MB | tar | 0 | Unavailable |
| OMIX007171-56 | PARDS; Patient ID: 12; Time point:T1; scRNA-seq | 1 | Other Type of Genomic Data | 22.54 MB | tar | 0 | Unavailable |
| OMIX007171-57 | Adult control; Patient ID: 17; scRNA-seq | 1 | Other Type of Genomic Data | 75.79 MB | tar | 0 | Unavailable |
| OMIX007171-58 | PARDS; Patient ID: 8; Time point:T1; BCR | 1 | Other Type of Genomic Data | 682.5 KB | tar | 0 | Unavailable |